1-(1-Boc-4-Piperidinyl)-4-Iodopyrazole CAS 877399-73-0 Maʻemaʻe ≥99.0% (HPLC)
ʻO Shanghai Ruifu Chemical Co., Ltd. ka mea hana nui o 1-(1-Boc-4-Piperidinyl) -4-Iodopyrazole (CAS: 877399-73-0) me ke kūlana kiʻekiʻe, waena o Crizotinib (CAS: 877399-52 -5).Hiki iā Ruifu Chemical ke hāʻawi aku i ka honua holoʻokoʻa, ke kumukūʻai hoʻokūkū, ka lawelawe maikaʻi loa, ka liʻiliʻi a me ka nui nui i loaʻa.E kūʻai i nā mea waena Crizotinib,Please contact: alvin@ruifuchem.com
| Inoa Kimia | 1-(1-Boc-4-Piperidinyl)-4-Iodopyrazole |
| Nā huaʻōlelo like | 1-Boc-4-(4-Iodo-1H-Pyrazol-1-yl)piperidine;tert-Butyl 4-(4-Iodo-1H-Pyrazol-1-yl)piperidine-1-Carboxylate;tert-Butyl 4-(4-Iodopyrazolyl)piperidinecarboxylate;Crizotinib haumia 16 |
| Kūlana Kūʻai | Ma ke Kahua, Hana Hana Kūʻai |
| Helu CAS | 877399-73-0 |
| ʻĀpana Molekala | C13H20IN3O2 |
| Kaumaha Molecular | 377.22 g/mol |
| Lae hehee | 97 ℃ |
| ʻO ka mānoanoa | 1.60±0.10 g/cm3 |
| Pilikino | Māmā Māmā |
| Waihona Temp. | 2~8 ℃, Pale mai ka Māmā |
| COA & MSDS | Loaʻa |
| Ke kumu | Shanghai, Kina |
| Māhele | Kūwaena o Crizotinib (CAS: 877399-52-5) |
| Brand | Kemika Ruifu |
| Nā mea | Nā Kūlana Nānā | Nā hualoaʻa |
| Ka nana aku | Keʻokeʻo i Melemele Māmā | Paʻa Keʻokeʻo |
| Maʻemaʻe / Kaʻina Hanana | ≥99.0% (HPLC) | 99.58% |
| Infrared Spectrum | Kūlike i ka hoʻolālā | Hoʻokō |
| 1 H NMR Spectrum | Kūlike i ka hoʻolālā | Hoʻokō |
| ESI+ | Kūlike | Hoʻokō |
| Ka hopena | Ua hoʻāʻo ʻia ka huahana a hoʻokō i nā kikoʻī i hāʻawi ʻia | |
Pūʻolo:ʻO ka ʻōmole, ʻeke ʻeke alumini, 25kg / pahu pahu pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E hoʻopaʻa paʻa i ka pahu a mālama i loko o kahi hale kūʻai maloʻo a maloʻo (2 ~ 8 ℃) a me kahi hale kūʻai maikaʻi mai nā mea like ʻole.E pale i ka malamalama a me ka wai.
Hoʻouna:Hāʻawi i ka honua ma ka lewa, e FedEx / DHL Express.Hāʻawi wikiwiki a hilinaʻi hoʻi.
Pehea e kūʻai ai?E ʻoluʻolu e kelepona maiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 mau makahiki ʻike?Loaʻa iā mākou ma mua o 15 mau makahiki o ka ʻike i ka hana ʻana a me ka hoʻokuʻu ʻana aku i kahi ākea ākea o nā intermediates pharmaceutical kiʻekiʻe a i ʻole nā kemika maikaʻi.
Mākeke Nui?E kūʻai aku i ka mākeke kūloko, ʻAmelika ʻĀkau, ʻEulopa, India, Korea, Iapana, Australia, etc.
Nā pono?ʻO ke kūlana kiʻekiʻe, ke kumukūʻai kūpono, nā lawelawe ʻoihana a me ke kākoʻo ʻenehana, ka lawe wikiwiki ʻana.
ʻAno maikaʻiHōʻoiaʻiʻo?Pūnaehana hoʻomalu maikaʻi koʻikoʻi.ʻO nā lako ʻoihana no ka nānā ʻana ʻo NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Nā laʻana?Hāʻawi ka hapa nui o nā huahana i nā laʻana manuahi no ka loiloi maikaʻi, pono e uku ʻia ke kumukūʻai e nā mea kūʻai aku.
Hooia Hale Hana?Welina mai ka loiloi hale hana.E ʻoluʻolu e hoʻopaʻa manawa ma mua.
MOQ?ʻAʻohe MOQ.ʻAe ʻia ke kauoha liʻiliʻi.
Manawa Hoʻouna? Inā i loko o ka waihona, ʻekolu lā hoʻouna ʻia.
Kaʻahele?Ma ka Express (FedEx, DHL), ma ka Air, ma ke Kai.
Nā palapala?Ma hope o ka lawelawe kūʻai: COA, MOA, ROS, MSDS, etc.
Hoʻohui Kuʻuna?Hiki ke hāʻawi i nā lawelawe synthesis maʻamau e kūpono i kāu mau pono noiʻi.
Kūkākūkā uku?E hoʻouna mua ʻia ka invoice Proforma ma hope o ka hōʻoia ʻana o ke kauoha, hoʻopili ʻia kā mākou ʻike panakō.Uku e T/T (Telex Transfer), PayPal, Western Union, etc.
1-(1-Boc-4-Piperidinyl)-4-Iodopyrazole (CAS: 877399-73-0) me ke kūlana kiʻekiʻe, waena o Crizotinib (CAS: 877399-52-5).ʻO Crizotinib kahi lāʻau lapaʻau i hoʻopaʻa ʻia no ka maʻi maʻi ʻaʻai liʻiliʻi liʻiliʻi i hoʻomohala ʻia e Pfizer, USA, ʻo secorri kahi lāʻau lapaʻau mua a me ka wā e hana ai i ka lāʻau lapaʻau i kuhikuhi ʻia no ka maʻi kanesa.Ua ʻae ʻia no ke kūʻai aku ʻana ma ʻAmelika Hui Pū ʻIa i ʻAukake 2011 a ua kākau ʻia i loko o nā alakaʻi lapaʻau maʻi maʻi maʻi maʻi maʻi āpau ma ka hopena o ka makahiki ma ke ʻano he lāʻau lapaʻau mua no nā maʻi maʻi ALK.ʻO ka hui pū ʻana me Crizotinib ʻo ia ke ʻano maʻi genetic mua me ka hoʻohana ʻana i ka fluorescence in situ hybridization (FISH) -VSIs ALK Break Apart FISH Probe Kit, ʻo ia ke ʻano i hoʻohana ʻia i kēia manawa i nā hoʻokolohua lapaʻau honua e ʻike i nā genes fusion EML4-ALK i NSCLC.E kōkua ana kēia ho'āʻo e ʻike i nā poʻe maʻi e pōmaikaʻi mai ka mālama ʻana iā Crizotinib.ma 25, ʻo kēia ka lāʻau lapaʻau mua e hoʻohana ʻia i ka mālama ʻana i nā poʻe maʻi me nā maʻi kūloko a i ʻole metastatic non-small cell lung cancer (NSCLC) ʻo ia ka anaplastic lymphoma kinase (ALK) -positive e like me ka mea i hoʻoholo ʻia e ka SFDA-apono ʻia.
ʻO Crizotinib (PF-02341066) ʻO Crizotinib he mea ikaika c-Met a me ALK inhibitor, ʻo nā waiwai IC50 i ka cell assay he 11 nM a me 24 nM.He mea paakiki no hoi ia o ROS1 me ka waiwai Ki malalo o 0.025 nM.Hiki i ka Crizotinib ke hoʻoulu i ka autophagy i nā ʻano laina maʻi maʻi maʻi maʻi ma o ke kāohi ʻana i ke ala STAT3.
