4-Chloro-6-Iodoquinazoline CAS 98556-31-1 Maʻemaʻe >98.0% (HPLC)

ʻO 4-Chloro-6-Iodoquinazoline (CAS: 98556-31-1) he mea waena i ka synthesis o Lapatinib (CAS: 231277-92-2) / Lapatinib Ditosylate Monohydrate (CAS: 388082-78-8).
ʻO Lapatinib kahi lāʻau lapaʻau lapaʻau hou e pili ana i ka maʻi maʻi umauma i hoʻomohala ʻia a hana ʻia e GlaxoSmithKline, i ʻae ʻia e ka US Food and Drug Administration ma Malaki 13, 2007. ʻO ka hōʻailona i ʻae ʻia i kēia manawa ua hui pū ʻia me ka capecitabine no ka maʻi maʻi umauma kiʻekiʻe a metastatic paha, a me nā maʻi maʻi maʻi umauma. pono e mālama ʻia me nā lāʻau lapaʻau mua ʻē aʻe.ʻO Tykerb kona inoa kālepa ma ʻAmelika Hui Pū ʻIa.Ma Dekemaba 14, 2007, ua ʻae ka European Medicines Agency (EMEA) i ka papa inoa o Lapatinib ma ʻEulopa ma lalo o ka inoa kālepa Tyverb.ʻO ka molecular targeted therapy no ka maʻi maʻi umauma e pili ana i ka mālama ʻana i nā oncogenes a me nā huahana hōʻike pili e pili ana i ka hanana a me ka ulu ʻana o ka maʻi maʻi umauma.ʻO nā lāʻau lapaʻau i hoʻopaʻa ʻia i ka molecular ke kāohi a pepehi i nā pūnaewele tumo ma ke kāohi ʻana i ka lawe ʻana i ka hōʻailona i loko o nā pūnaewele a i ʻole nā ​​​​pūnaewele pili e hoʻomalu i nā loli i ka hōʻike ʻana o ke ʻano.ʻO Lapatinib kahi mole liʻiliʻi liʻiliʻi epidermal growth factor tyrosine kinase inhibitor.Ua hōʻike ʻia nā hoʻokolohua lapaʻau no ka poʻe maʻi maʻi maʻi maʻi umauma HER2 i hoʻomohala i ke kū'ē iā Roche's Herceptin (Herceptin), he hopena maikaʻi ko Lapatinib.ʻO nā hoʻāʻo in vitro, ua loaʻa i ka Lapatinib kahi hopena pale ulu nui ma luna o Her-2 overexpressing nā laina kelepona maʻi maʻi umauma.Ma ka Phase I nā ho'āʻo o ka maʻi maʻi umauma kiʻekiʻe me Her-2 overexpression, ʻo Lapatinib pū kekahi i ka helu kūpono kiʻekiʻe a ʻaʻohe kūʻē kūʻē iā Herceptin (trastuzumab).No ka mea he mole liʻiliʻi kona ʻano, ʻaʻole like me Herceptin (trastuzumab), hiki iā ia ke komo i ka pale koko-lolo a loaʻa kekahi hopena therapeutic i ka metastasis lolo o ka maʻi maʻi umauma.