Celecoxib CAS 169590-42-5 Hōʻike 98.0~102.0%

ʻO ka wehewehe pōkole:

Inoa Kemika: Celecoxib

Synonyms: Celebrex;Celebra;SC-58635

CAS: 169590-42-5

ʻIke: 98.0~102.0%

ʻAno: Keʻokeʻo a ʻaneʻane keʻokeʻo Crystalline Powder

Hoʻokaʻaʻike: Kauka Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


Huahana Huahana

Nā Huahana Pili

Huahana Huahana

wehewehe:

ʻO Shanghai Ruifu Chemical Co., Ltd. ka mea hana nui o Celecoxib (CAS: 169590-42-5) me ke kūlana kiʻekiʻe.Hiki iā Ruifu Chemical ke hāʻawi aku i ka honua holoʻokoʻa, ke kumukūʻai hoʻokūkū, ka lawelawe maikaʻi loa, ka liʻiliʻi a me ka nui nui i loaʻa.Kūʻai iā Celecoxib,Please contact: alvin@ruifuchem.com

Nā mea waena o Celecoxib:

Na Waiwai Kemika:

Inoa Kimia ʻO Celcoxib
Nā huaʻōlelo like Celebrex;Celebra;Celcox;Onsenal;Solexa;SC-58635;SC 58635;YM-177;4-[5-(4-Methylphenyl)-3-(Trifluoromethyl)-1H-Pyrazol-1-yl] benzenesulfonamide;5-(4-Methylphenyl)-1-(4-Sulfamoylphenyl)-3-(Trifluoromethyl)pyrazole
Kūlana Kūʻai Ma ke Kahua, Hana Hana Kūʻai
Helu CAS 169590-42-5
ʻĀpana Molekala C17H14F3N3O2S
Kaumaha Molecular 381.37 g/mol
Lae hehee 160.0 a 165.0 ℃
ʻO ka mānoanoa 1.43±0.10 g/cm3
Hiki i ka wai ʻAʻole hiki ke hoʻonā i ka wai
Ka hikiwawe Hiki loa i ka Methanol;Hiki ke hoʻoheheʻe ʻia i loko o ka Ethanol
COA & MSDS Loaʻa
Laʻana Loaʻa
Ke kumu Shanghai, Kina
Brand Kemika Ruifu

Nā kikoʻī:

Nā mea Nā Kūlana Nānā Nā hualoaʻa
Ka nana aku Keʻokeʻo a ʻaneʻane keʻokeʻo Crystalline pauda Hoʻokō
Hoʻāʻo 98.0~102.0% 99.8%
Lae hehee 160.0 a 165.0 ℃ 162.2 ℃
Wai na Karl Fischer <0.50% 0.11%
Koena ma ka Ignition <0.20% 0.05%
Nā Metala Kaumaha (Pb) ≤20ppm <10ppm
ʻO Celecoxib Pilina Hui A <0.40% <0.20%
Celecoxib Huihui Pili B <0.10% <0.10%
He haumia ʻaʻole i hōʻike ʻia ke kanaka <0.10% <0.10%
Huina haumia <0.50% 0.20%
Infrared Spectrum Kūlike me ka Hoʻolālā Hoʻokō
1H NMR Spectrum Kūlike me ka Hoʻolālā Hoʻokō
Ka hopena Ua hoʻāʻo ʻia ka huahana a hoʻokō me nā kikoʻī i hāʻawi ʻia

Pūʻolo/Paʻa/Hoʻouna:

Pūʻolo:ʻO ka ʻōmole Fluorinated, ʻeke ʻeke alumini, 25kg / pahu pahu pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E hoʻopaʻa paʻa i ka pahu a mālama i loko o kahi hale kūʻai maloʻo a maloʻo (2 ~ 8 ℃) a me kahi hale kūʻai maikaʻi mai nā mea like ʻole.E pale i ka malamalama a me ka wai.
Hoʻouna:Hāʻawi i ka honua ma ka lewa, e FedEx / DHL Express.Hāʻawi wikiwiki a hilinaʻi hoʻi.

169590-42-5 - USP35 Kūlana:

ʻO Celcoxib
C17H14F3N3O2S 381.4
4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide;
p-[5-p-Tolyl-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide [169590-42-5]
HOAKAKA
Loaʻa iā Celecoxib ka NLT 98.0% a me NMT 102.0% o C17H14F3N3O2S, helu ʻia ma ke kumu anhydrous
IKE
• A. INFRARED Absorption <197>: [NOTE-Methods <197A>, <197K>, or <197M> under Infrared Absorption hiki ke hoʻohana.]
[E MANAʻO-Inā ʻokoʻa nā kikoʻī i loaʻa, e hoʻoheheʻe i ka mea e nānā ʻia a me ka Reference Standard i loko o ka waiʻona isopropyl, e hoʻoheheʻe i kahi maloʻo, a hoʻopaʻa i ke kikoʻī hou.]
B. ʻO ka manawa paʻa o ke kiʻekiʻe nui o ka hāʻina Laʻana e pili ana i ka hopena maʻamau, e like me ka loaʻa ʻana ma ka Assay.
HANA
• HANA
Hoʻopaʻa: 2.7 g/L o ka monobasic potassium phosphate i hoʻoponopono ʻia me ka waikawa phosphoric i kahi pH o 3.0 ± 0.2
Māhele paʻa: Methanol, acetonitrile, a me Buffer (3:1:6)
Mea hoʻoheheʻe: Methanol a me ka wai (3: 1)
Haʻina kūpono ʻōnaehana: 0.5 mg/mL o USP
ʻO Celecoxib RS a me 2.4 µg/mL kēlā me kēia o USP Celecoxib Pūhui Pili A RS a me USP Celecoxib Pūhui B RS i Diluent.
Haʻina maʻamau: 0.5 mg/mL o USP Celecoxib RS i ka Diluent
Laʻana hoʻonā: 0.5 mg/mL o Celecoxib i Diluent
Pūnaehana Chromatographic
(E nana Chromatography <621>, Pūnaehana Pono.)
Ke ano: LC
ʻIke: UV 215 nm
kolamu: 4.6-mm × 25-cm;5-µm paʻi L11
Ka wela o ke kolamu: 60°
Kahe kahe: 1.5 mL / min
Ka nui o ka injection: 25 µL
Ka manawa holo: Ma kahi o 1.5 manawa o ka celecoxib peak elution
Kūpono ʻōnaehana
Nā Laʻana: Haʻina kūpono ʻōnaehana a me ka hopena maʻamau
Nā koi kūpono
Hoʻoholo: NLT 1.8 ma waena o ka pūhui pili celecoxib A me Celecoxib a me NLT 1.8 ma waena o Celecoxib a me Celecoxib pili pūhui B.
Hoʻokaʻawale maʻamau pili: NMT 0.73%, Haʻina maʻamau
Kānāwai
Nā Laʻana: Haʻina maʻamau a me ka hāʻina Laʻana
E helu i ka pākēneka o C17H14F3N3O2S ma ka ʻāpana o Celecoxib i lawe ʻia:
Ka hopena = (rU/rS) × (CS/CU) × 100
rU = pane kiʻekiʻe mai ka hāʻina Laʻana
rS = pane kiʻekiʻe mai ka hoʻonā maʻamau
CS = ka manaʻo o ka hoʻonā maʻamau (mg/mL)
CU = ka hoʻopaʻa ʻana o ka hāpana laʻana (mg/mL)
Nā pae hoʻohālikelike: 98.0% ~ 102.0% ma ke kumu anhydrous
NA mea haumia
Nā mea haumia ʻole
• NA METAL HEAVY: NMT 20 ppm
Mea hoʻoheheʻe: Acetone a me ka wai (17: 3)
Hoʻonā maʻamau: E hoʻoheheʻe ʻia 1.0 mL o ka Solution Lead maʻamau, i hoʻomākaukau ʻia e like me ke kuhikuhi ʻana ma lalo o nā Metala Kaumaha <231>, Nā Hoʻohui Kūikawā, me ka Diluent i 20 mL.
Laʻana hoʻonā: Dissolve 0.50 g o Celecoxib i 20mL o Diluent.
ʻO ka hoʻonā hakahaka: 20 mL o ka Diluent
Kānāwai
Nā Laʻana: Haʻina maʻamau, Haʻina Blank, a me ka hāʻina Laʻana
I kēlā me kēia haʻina, e hoʻohui i 2 mL o ka pH 3.5 Acetate Buffer i hoʻomākaukau ʻia e like me ke kuhikuhi ʻana ma lalo o nā Metala Kaumaha <231>, Ka Hana I. Hoʻohui, a hoʻohui i kēlā me kēia haʻina 1.2 mL o thioacetamide–glycerin base TS.E hui koke, a e ku no 2 min.E hāʻawi i nā haʻina ma o kahi kānana o ka nui pore 0.45-µm.E hoʻohālikelike i nā kiko ma nā kānana i loaʻa mai kēlā me kēia o nā haʻina.
Paʻa e ʻae ai: ʻAʻole ʻoi aku ka ikaika o ka waihoʻoluʻu ʻeleʻele ʻeleʻele o ka wahi i loaʻa mai ka hāʻina laʻana ma mua o ke kiko i loaʻa mai ka solution Standard.He kūpono ʻole ka hoʻāʻo inā ʻaʻole hōʻike ka hoʻonā Kūlana i kahi waihoʻoluʻu ʻeleʻele-ʻeleʻele i hoʻohālikelike ʻia me ka solution Blank.
• KOE MA KA HANA <281>: NMT 0.2%, me ka hoohana ana i ka platinum crucible
Nā mea haumia kino
• HANA
Buffer, Mobile phase, Diluent, ʻO ka hopena kūpono o ka ʻōnaehana, Sample solution, a me ka ʻōnaehana Chromatographic: E hoʻomau e like me ke kuhikuhi ʻana i ka Assay.
Haʻina maʻamau: 0.5 µg/mL o USP Celecoxib RS i ka Diluent
Kūpono ʻōnaehana
Nā Laʻana: Haʻina kūpono ʻōnaehana a me ka hopena maʻamau
Nā koi kūpono
Hoʻoholo: NLT 1.8 ma waena o Celecoxib pili pūhui A me Celecoxib a me NLT 1.8 ma waena o Celecoxib a me Celecoxib pili pūhui B, Pūnaehana kūpono kūpono.
Lakiō hōʻailona-a-noise: NLT 20, Hoʻonā maʻamau
Kānāwai
Nā Laʻana: Haʻina maʻamau a me ka hāʻina Laʻana
E helu i ka pākēneka o kēlā me kēia haumia ma ka ʻāpana o Celecoxib i lawe ʻia:
Ka hopena = (rU/rS) × (CS/CU) × 100
rU = pane kiʻekiʻe no kēlā me kēia haumia i ka Haʻina Haʻawina
rS = pane kiʻekiʻe o celecoxib i ka hoʻonā Kūlana
CS = ka hoʻopaʻa ʻana o ka celecoxib i ka hopena maʻamau (mg/mL)
CU = ka hoʻopaʻa ʻana o Celecoxib i ka hāʻina Laʻana (mg/mL)
Nā pae ʻae ʻae
Nā haumia o kēlā me kēia kanaka: E nānā i ka Papa 1.
[MAKEMAKE-E hoʻowahāwahā i kekahi kiʻekiʻe haumia ma lalo o 0.05%.]
Papa 1

inoa Manawa Paa Pilina Nā Koina ʻae NMT (%)
Celecoxib pili pūhui Aa 0.9 0.4
ʻO Celcoxib 1.0
Celecoxib pili pūhui Bb 1.1 0.10
He haumia ʻaʻole i hōʻike ʻia 0.10
Huina haumia 0.5

he 4-[5-(3-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide.
b 4-[3-(4-Methylphenyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide.
NA HOAO KUAI
• KA HOʻOMAʻI O KA WAI, Ke ʻano I <921>: NMT 0.5%, me ka hoʻohana ʻana i kahi hāpana 400-mg
NA KOI HOU
• PACKAGING a me ka mālama ʻana: mālama ʻia i loko o nā pahu paʻa, pale ʻia mai ka māmā a me ka wai.E mālama i ka lumi wela
• USP REFERENCE STANDARD <11>
USP Celecoxib RS
p-[5-p-Tolyl-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
C17H14F3N3O2S 381.4
USP Celecoxib Puhui Pili A RS
4-[5-(3-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide.
C17H14F3N3O2S 381.4
USP Celecoxib Puhui Pili B RS
4-[3-(4-Methylphenyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide.
C17H14F3N3O2S 381.4

Pono:

ʻO ka mana kūpono: lawa nā lako a me nā ʻenehana

ʻOihana Hoʻonaʻauao: Hoʻokahi lawelawe kūʻai kūʻai

Puke OEM: Loaʻa ka pūʻolo maʻamau a me ka lepili

Hoʻouna wikiwiki: Inā i loko o ke kumukūʻai, ʻekolu lā hoʻouna i hōʻoia ʻia

Hoʻolako Paʻa: E mālama i ka waiwai kūpono

Kākoʻo ʻenehana: Loaʻa ka hopena ʻenehana

Hana Hana Hana Kuʻuna: Mai ka grama a hiki i ke kilo

Kūlana Kiʻekiʻe: Hoʻokumu i kahi ʻōnaehana hōʻoia maikaʻi piha

FAQ:

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169590-42-5 - ʻIke Palekana:

Nā hōʻailona pōʻino Xn - Poino
Nā Code Risk R20/21/22 - He pōʻino ma ka inhalation, pili me ka ʻili a inā ale ʻia.
R52 - He pōʻino i nā mea ola wai
R61 - Hiki ke hoʻopilikia i ke keiki hānau ʻole
R60 - Hiki ke hoʻopilikia i ka momona
Ka wehewehe palekana S22 - Mai hanu i ka lepo.
S24/25 - Hōʻalo i ka pili ʻana me ka ʻili a me nā maka.
S28 - Ma hope o ka pili ʻana me ka ʻili, holoi koke me ka nui o ke kopa.
S37/39 - E hoʻohana i nā mīkina lima kūpono a me ka pale maka/maka
UN ID UN 3077 9 / PGIII
WGK Kelemānia 3
RTECS DB2944937
HS Code 2935900090
Papa Hazard HOOLAHA

169590-42-5 - Noi:

ʻO Celecoxib a me Rofecoxib ʻelua i hoʻohana ʻia i kēia manawa COX-2 inhibitors.Ua hoʻomohala maikaʻi ʻia e GD Searle & Pfizer Co. (US,) i hoʻokuʻu ʻia i ka makahiki 1999, inoa kālepa: Celebrex.ʻO Celecoxib kahi mea nonsteroidal, anti-inflammatory agent me ka analgesic nui a me nā hopena anti-inflammatory, e hana ana i ka haʻahaʻa haʻahaʻa o nā maʻi ʻeha o ka ʻōpū o luna a me nā pilikia ʻē aʻe.Hoʻohana ʻia i ka lāʻau lapaʻau no ka mālama ʻana i ka osteoarthritis a me ka maʻi rheumatoid arthritis, me kahi hana analgesic anti-inflammatory, hoʻomaha i nā hōʻailona a me nā hōʻailona o ka osteoarthritis a me ka rheumatoid arthritis.

169590-42-5 - Hoʻohana:

Celecoxib (CAS: 169590-42-5), No ka hoʻomaha a me ka mālama ʻana i ka osteoarthritis (OA), rheumatoid arthritis (RA), juvenile rheumatoid arthritis (JRA), ankylosing spondylitis, ʻeha nui, dysmenorrhea mua a me ka hoʻopili waha i ka mālama maʻamau no nā maʻi. me ka polyposis adenomatous ʻohana.

169590-42-5 - Nā Hana Hana:

ʻO Celecoxib (CAS: 169590-42-5) ka hopena anti-inflammatory a me analgesic o NSAID.Ma muli o kona ʻano kemika, hiki ke hoʻohui ʻia me COX-2, koho koho i ka COX-2.Hoʻopili ʻia kāna hui phenyl me ke kahawai hydrophobic o COX-2, a ʻo kāna hydrophilic sulfonamide e hana i ke kaulahao hydrogen me 513 arginine a me 90 histidine i loko o ka ʻeke ʻaoʻao COX-2.Ua pili pū nō hoʻi me ka arginine ma ke kūlana COX-2120 a ke pāʻani nei i ka pale ʻana i ka COX-2 mai ka hoʻololi ʻana i ka waika arachidonic i prostaglandins i mea pōʻino i ke kino o ke kanaka. -2, ʻAʻole hiki iā Celecoxib ke komo i ka mole COX-1, ʻaʻole hoʻi e kāohi i kona hoʻololi ʻana i ka waika arachidonic i prostaglandins. No laila, loaʻa iā ia nā hopena anti-inflammatory a me analgesic maikaʻi, pale i ka mucosa o ka ʻōpū, pale i ke kahe koko renal, hoʻoponopono i ka platelet aggregation, a hoʻonā i ka nā pilikia ʻeha o ka ʻōpū o nā NSAID maʻamau.

169590-42-5 - Nā hōʻailona:

Hōʻike ʻia ʻo Celecoxib (CAS: 169590-42-5) no ka mālama ʻana i ka osteoarthritis a me ka rheumatoid arthritis.Hoʻopaʻa ʻia kona hoʻohana ʻana i nā poʻe me ka hypersensitivity i sulfonamides a i ʻole NSAIDs ʻē aʻe.Pono e hoʻohana me ka akahele i ka poʻe me ka maʻi hepatic.Loaʻa nā pilina me nā lāʻau ʻē aʻe e hoʻoulu ai i ka CYP2C9 (eg rifampin rifampin) a i ʻole e hoʻokūkū i ka metabolism e kēia enzyme (e laʻa me fluconazole, leflunomide).ʻO nā hopena maikaʻi ʻole maʻamau i ka celecoxib ʻo ia nā hopena GI maʻalahi e like me ka dyspepsia, ka ʻōpū, a me ka ʻeha o ka ʻōpū.ʻAʻole hiki ke loaʻa nā hopena GI koʻikoʻi a me ka renal.

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