Chloramphenicol CAS 56-75-7 Maʻemaʻe ≥99.0% (HPLC) Maʻemaʻe Kiʻekiʻe
Mea Manufacturer lako me High maemae a me Commercial Production
(1R,2R)-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol CAS 716-61-0
(1S,2S)-(+)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol CAS 2964-48-9
Chloramphenicol CAS 56-75-7
Inoa Kimia | Chloramphenicol |
Nā huaʻōlelo like | D-(-)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol;2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)-2-propyl]acetamide |
Helu CAS | 56-75-7 |
Kūlana Kūʻai | Ma ka waihona, ʻoi aku ka nui o ka hana a hiki i nā tona |
ʻĀpana Molekala | C11H12Cl2N2O5 |
Kaumaha Molecular | 323.13 |
Lae hehee | 149.0 a i 153.0 ℃ (māmā) |
Pilikino | Māmā Māmā |
Ka hoʻoheheʻe | Hiki loa i ka Ethanol, Methanol, Acetone.Hiki ke hoʻoheheʻe ʻia i loko o ka Etera, Chloroform.ʻAʻole hiki ke hoʻonā i ka Benzene.ʻAʻole hiki ke hoʻoheheʻe ʻia i ka wai |
Kūlana Hoʻouna | Hoʻouna ʻia ma lalo o ka wela ambient |
COA & MSDS | Loaʻa |
Ke kumu | Shanghai, Kina |
Brand | ʻO Ruifu Chemical |
'ikamu | Nā kikoʻī |
Ka nana aku | Keokeo a i ka pauda Melemele Malamalama |
ʻIkepili A | Infrared Absorption |
ʻIkepili B | ʻO ka manawa paʻa o ka piko nui ma ka chromatogram o ka hoʻomākaukau Assay e pili ana i kēlā i loko o ka chromatogram o ka hoʻomākaukau maʻamau, e like me ka loaʻa ma ka Assay. |
Hoʻololi Optical kikoʻī | +17.0°~+20.0° |
Lae hehee | 149.0~153.0 ℃ |
Crystallinity | Kū i nā koi |
pH | 4.5-7.5 |
Hoʻokahi haumia | ≤0.50% |
Huina paumaele | ≤1.00% |
Metala Kaumaha | ≤20ppm |
Arsenic | ≤1ppm |
Nalo ma ka maloo | ≤0.50% (105℃, 3 hola) |
Koena ma ka Ignition | ≤0.10% |
Maʻemaʻe / Kaʻina Hanana | ≥99.0% (HPLC) |
Kūlana hoʻāʻo | ʻOihana Kūlana;JP;USP |
Pūʻolo: ʻO ka'ōmole, Aluminum foil eke, 25kg/Drum, aiʻole e like me ka makemake o ka mea kūʻai.
Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;Pale mai ka malamalama, ka makū.
Chloramphenicol
C11H12Cl2N2O5 323.13 [56-75-7].
Aia ka Chloramphenicol ma lalo o 97.0 pākēneka a ʻaʻole ʻoi aku ma mua o 103.0 pākēneka o C11H12Cl2N2O5.
Hoʻopili a mālama ʻia - mālama i loko o nā pahu paʻa.
Lepili-Ma kahi i manaʻo ʻia e hoʻohana i ka hoʻomākaukau ʻana i ka injectable a i ʻole nā mea hoʻohana sterile ʻē aʻe, ua ʻōlelo ka lepili he sterile a pono e hoʻokō ʻia i ka hana hou ʻana i ka wā o ka hoʻomākaukau ʻana i nā ʻano ʻano injectable a i ʻole nā mea ʻē aʻe sterile.
Nā kūlana hōʻike USP <11>-
USP Chloramphenicol RS Kaomi e nānā i ke kūkulu
USP Endotoxin RS
ʻike-
A: Infrared Absorption <197K>.
B: ʻO ka manawa paʻa o ka piko nui ma ka chromatogram o ka hoʻomākaukau Assay e pili ana i kēlā i loko o ka chromatogram o ka hoʻomākaukau maʻamau, e like me ka loaʻa ʻana ma ka Assay.
Māhele heheʻe <741>: ma waena o 149 a me 153.
Ka hoʻololi kikoʻī <781S>: ma waena o +17.0 a me +20.0.
ʻO ka hopena hoʻāʻo: 50 mg, ʻaʻole maloʻo, no ka mL, i loko o ka waiʻona maloʻo.
Crystallinity <695>: kūpono i nā koi.
Bacterial endotoxins 85-Ma kahi o Chloramphenicol i manaʻo ʻia e hoʻohana i ka hoʻomākaukau ʻana i nā ʻano hana injectable, ʻaʻole i ʻoi aku ma mua o 0.2 USP Endotoxin Unit no ka mg o ka chloramphenicol.
Sterility 71- Ma kahi e ʻōlelo ai ka lepili he sterile ʻo Chloramphenicol, hoʻokō ʻo ia i nā koi ke hoʻāʻo ʻia e like me ke kuhikuhi ʻana no ka Membrane Filtration ma lalo o ka hoʻāʻo ʻana no ka maʻemaʻe o ka huahana e nānā ʻia, koe wale nō ka hoʻohana ʻana i 1 g o ka specimen paʻa.
pH <791>: ma waena o 4.5 a me 7.5, i loko o ka wai hoʻokuʻu ʻia he 25 mg no ka mL.
Chromatographic maʻemaʻe-E hoʻoheheʻe i ka nui o Chloramphenicol i kaupaona pololei ʻia i ka methanol e loaʻa ai kahi hopena hoʻāʻo i loaʻa he 10 mg no ka mL.E hoʻomākaukau i ka hopena o USP Chloramphenicol RS i loko o ka methanol me 10 mg no ka mL (Hoʻonā maʻamau A).E hoʻoheheʻe i nā ʻāpana o ka solution maʻamau A me ka methanol no ka loaʻa ʻana o ka solution maʻamau B me 100 µg no ka mL a me ka solution maʻamau C i loaʻa iā 50 µg no mL.E hoʻopili i nā ʻāpana 20-µL kaawale o ka hoʻonā hoʻāʻo a me nā hāmeʻa maʻamau B a me C i kahi pā chromatographic ʻāpana lahilahi kūpono (e nānā i ka Chromatography 621), i uhi ʻia me kahi papa 0.25-mm o ka hui ʻana o ka chromatographic silica gel.E hoʻomohala i ka chromatogram i loko o kahi ʻōnaehana hoʻoheheʻe i hui pū ʻia me ka chloroform, methanol, a me ka ʻakika acetic glacial (79:14:7) a hiki i ka neʻe ʻana o ka ʻūhā mua ma kahi o ʻekolu hapahā o ka lōʻihi o ka pā.Wehe i ka pā mai ke keʻena, maloʻo i ka ea, a nānā ma lalo o ke kukui UV pōkole-lōʻihi: ʻaʻole ʻoi aku ka nui o nā wahi ʻē aʻe ma waho o ka wahi nui i loaʻa mai ka hopena hoʻāʻo i ka nui a i ʻole ka ikaika. ), a ʻo ka huina o nā haumia i hōʻike ʻia e nā kiko āpau ʻē aʻe ma waho o ke kiko nui, ma muli o ka hoʻohālikelike ʻana i ka ikaika o ia mau kiko me ka ikaika o nā kiko nui i loaʻa mai nā ʻano maʻamau B a me C, ʻaʻole i ʻoi aku ma mua o 2% .
hoʻāʻo-
ʻĀpana paʻa-E hoʻomākaukau i kahi hui kānana kūpono o ka wai, methanol, a me ka ʻakika acetic glacial (55:45:0.1).Hana i nā hoʻololi inā pono (e nānā i ka System Suitability ma lalo o Chromatography 621).
Hoʻomākaukau maʻamau- E hoʻoheheʻe i ka nui o ka USP Chloramphenicol RS i kaupaona pono ʻia ma ka pae Mobile, a hoʻoheheʻe ʻia me ka nui, a me ka stepwise inā pono, me ka pae Mobile e loaʻa ai kahi hopena i ʻike ʻia ma kahi o 80 µg no mL.E kānana i kahi ʻāpana o kēia hoʻonā ma o kahi kānana porosity 0.5-µm a ʻoi aku ka maikaʻi, a hoʻohana i ka kānana maʻemaʻe e like me ka hoʻomākaukau maʻamau.
Hoʻomākaukau hoʻāʻo- E hoʻololi ma kahi o 200 mg o Chloramphenicol, i kaupaona pono ʻia, i loko o kahi pahu volumetric 100-mL, e hoʻohui i ka pae Mobile i ka leo, a hui.E hoʻololi i 4.0 mL o ka hopena i loko o kahi pahu volumetric 100-mL, e hoʻoheheʻe me ka pae Mobile i ka leo, a hui.E kānana i kahi ʻāpana o kēia hoʻonā ma o kahi kānana porosity 0.5-µm a ʻoi aku ka maikaʻi, a hoʻohana i ka kānana maʻemaʻe e like me ka hoʻomākaukau ʻana i ka Assay.
Pūnaehana Chromatographic (e nānā i ka Chromatography <621>)-Ua hoʻolako ʻia ka chromatograph wai me kahi mea ʻike 280-nm a me kahi kolamu 4.6-mm × 10-cm i loaʻa iā 5-µm packing L1.ʻO ka nui o ke kahe e pili ana i 1 mL i kēlā me kēia minuke.ʻO Chromatograph i ka hoʻomākaukau maʻamau, a hoʻopaʻa i nā pane kiʻekiʻe e like me ke kuhikuhi ʻana ma lalo o ke Kaʻina: ʻo ke kolamu kūpono i hoʻoholo ʻia mai ka analyte peak ʻaʻole i emi iho ma mua o 1800 theoretical plates, ʻaʻole i ʻoi aku ke kumu huelo ma mua o 2.0, a ʻaʻole ʻo ka ʻokoʻa maʻamau pili no nā injections replicate. ʻoi aku ma mua o 1.0%.
Kaʻina hana-[note-E hoʻohana i nā kiʻekiʻe kiʻekiʻe kahi i hōʻike ʻia ai nā pane kiʻekiʻe.] Hoʻokaʻawale i nā puke like (ma kahi o 10 µL) o ka hoʻomākaukau maʻamau a me ka hoʻomākaukau Assay i loko o ka chromatograph, hoʻopaʻa i nā chromatograms, a ana i nā pane no nā piko nui.E helu i ka nui, ma mg, o C11H12Cl2N2O5 ma ka mahele o Chloramphenicol i laweia e ke kumu:
2.5C(rU / rS)
i loko o ka C ka hoʻopaʻa ʻana, ma µg per mL, o USP Chloramphenicol RS i ka hoʻomākaukau maʻamau, a ʻo rU a me rS nā pane kiʻekiʻe i loaʻa mai ka hoʻomākaukau Assay a me ka hoʻomākaukau maʻamau, kēlā me kēia.
Chloramphenicol
C11H12Cl2N2O5: 323.13
2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide [56-75-7]
ʻO Chloramphenicol ʻaʻole i emi iho ma mua o 980 mg (potency) a ʻaʻole iʻoi aku ma mua o 1020 mg (potency) no ka mg, i helu ʻia ma ke kumu maloʻo.Hōʻike ʻia ka mana o Chloramphenicol e like me ka nuipaʻa (potency) o ka chloramphenicol (C11H12Cl2N2O5).
Hōʻike ʻia ʻo Chloramphenicol e like me ke keʻokeʻo a i ke keʻokeʻo melemele, nā kristal a i ʻole ka pauka crystalline.
Hiki ke hoʻoheheʻe ʻia i ka methanol a me ka ethanol (99.5), a hiki ke hoʻoheheʻe iki ʻia i ka wai.
Identification (1) E hoʻoholo i ke kiko o ka absorption o ka hāpana hāpana i loaʻa ma ka Assay e like me ke kuhikuhi ʻana ma lalo o Ultraviolet-visible Spectrophotometry <2.24>, a hoʻohālikelike i ke kikoʻī me ka Reference Spectrum a i ʻole ke kikoo o kahi hopena o Chloramphenicol RS i hoʻomākaukau ʻia ma ke ʻano like me. ka hāpana hāpana: hōʻike nā kikoʻī ʻelua i ka ikaika like o ka absorption ma nā lōʻihi nalu like.
(2) E hoʻoholo i ke kiko kikoʻī infrared o Chloramphenicol e like me ke kuhikuhi ʻana ma ke ʻano pāpaʻi bromide pāpaʻa ma lalo o Infrared Spectrophotometry <2.25>, a hoʻohālikelike i ke kikoʻī me ka Spectrum Reference a i ʻole ke kikoo o Chloramphenicol RS: hōʻike nā kikoʻī ʻelua i ka ikaika like o ka absorption i ka like. helu nalu.
ʻO ka hoʻololi ʻana i ka ʻike maka <2.49> [a]20D: +18.5~+21.5℃ (1.25 g, ethanol (99.5), 25 mL, 100 mm).
Ka helu hehee <2.60> 150~155 ℃
Maʻemaʻe (1) Nā metala kaumaha <1.07>-E hoʻomau me 1.0 g o Chloramphenicol e like me ke ʻano 2, a hana i ka hoʻāʻo.E hoʻomākaukau i ka hoʻonā hoʻomalu me 2.5 mL o ka mea hoʻonā alakaʻi maʻamau (ʻaʻole ʻoi aku ma mua o 25 ppm).
(2) Arsenic <1.11>-E hoʻomākaukau i ka hoʻonā ho'āʻo me 2.0 g o Chloramphenicol e like me ka Hana 4, a hana i ka ho'āʻo (ʻaʻoleʻoi aku ma mua o 1 ppm).
(3) Nā mea pili-E hoʻoheheʻe i 0.10 g o Chloramphenicol i 10 mL o ka methanol, a hoʻohana i kēia haʻina e like me ka hāpana hāpana.Pipet 1 mL o ka hāpana hāpana, hoʻohui i ka methanol e hana pono i 100 mL, a hoʻohana i kēia haʻina e like me ka hopena maʻamau (1).Pipet 10 mL o ka hoʻonā maʻamau (1), e hoʻohui i ka methanol e hana pono i 20 mL, a e hoʻohana i kēia haʻina e like me ka hopena maʻamau (2).E hana i ka ho'āʻo me kēia mau haʻina e like me ka kuhikuhi ʻana ma lalo o Thin-layer Chromatography <2.03>.E kau i ka 20 mL o kēlā me kēia hāpana hāpana a me nā hāʻina maʻamau (1) a me (2) ma luna o kahi pā silica gel me ka hōʻailona fluorescent no ka chromatography thin-layer, e hoʻomohala i ka pā me ka hui ʻana o ka chloroform, methanol a me ka acetic acid (100) ( 79:14:7) i kahi mamao ma kahi o 15 knm, a maloʻo i ka pā.E noʻonoʻo ma lalo o ke kukui ultraviolet (lōʻihi nalu nui: 254 nm): ʻaʻole ʻoi aku ka ikaika o nā kiko ʻē aʻe ma waho o ke kiko nui a me ke kiko ma ke kumu kumu i loaʻa mai ka hāpana hāpana ma mua o ke kiko i loaʻa mai ka solution maʻamau (1), a me ka huina nui. o kēia mau kiko mai ka hāpana hāpana ʻaʻole ʻoi aku ma mua o 2.0%.
ʻAʻole i ʻoi aku ma mua o 0.5% (1 g, 105℃, 3 hola).
ʻAʻole i ʻoi aku ma mua o 0.1%(1 g).
E kaupaona pololei i ka nui o Chloramphenicol a me Chloramphenicol RS, e like me 0.1 g (mana), e hoʻoheheʻe i kēlā me kēia i loko o 20 mL o ka methanol, a hoʻohui i ka wai i 100 mL.Pipet 20 mL i kēlā me kēia o kēia mau hoʻonā, a hoʻohui i ka wai a hiki i ka 100 mL.Pipet 10 mL i kēlā me kēia o kēia mau haʻina, e hoʻohui i ka wai e hana pono i 100 mL, a e hoʻohana i kēia mau haʻina e like me ka hāpana hāpana a me ka hopena maʻamau.E hoʻoholo i ka hoʻopaʻa ʻana, AT a me AS, ma 278 nm o ka hāpana hāpana a me ka hopena maʻamau e like me ke kuhikuhi ʻana ma lalo o Ultraviolet-visible Spectrophotometry <2.24>.
Ka nui [mg (manakia)] o chloramphenicol (C11H12Cl2N2O5)
= MS × AT/AS × 1000
MS: Ka nui [mg (mana)] o Chloramphenicol RS
lawe ʻia
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Nā Code Risk R45 - Hiki ke kumu i ke kanesa
R11 - Hiki ke ahi
R39/23/24/25 -
R23/24/25 - He mea ʻona ma ka inhalation, pili me ka ʻili a inā ale ʻia.
ʻO ka wehewehe palekana S53 - Hōʻalo i ka hoʻolaha - loaʻa nā ʻōlelo kuhikuhi kūikawā ma mua o ka hoʻohana ʻana.
S45 - Inā loaʻa ka pōʻino a i ʻole ʻoluʻolu ʻoe, e ʻimi koke i ka ʻōlelo aʻo kino (e hōʻike i ka lepili inā hiki.)
S16 - E hoʻokaʻawale i nā kumu o ke ahi.
S36/37 - E hoʻohana i nā lole pale kūpono a me nā mīkina lima.
UN ID 2811
WGK Kelemānia 3
RTECS AB6825000
FLUKA BRAND F CODES 3-10
TSCA ʻAe
HS Code 2941400000
Papa Hazard 3
ʻona LD50 waha i ka ʻiole: 2500mg/kg
P501: E hoʻolei i nā mea i loko/ pahu i kahi mea kanu hoʻolei ʻōpala i ʻāpono ʻia.
P260: Mai hanu i ka lepo/huhū/ kinoea/ noe/ mahu.
P270: Mai ʻai, inu a puhi i ka wā e hoʻohana ai i kēia huahana.
P202: Mai lawelawe a heluhelu ʻia a hoʻomaopopo ʻia nā ʻōlelo mālama palekana.
P201: E kiʻi i nā ʻōlelo kuhikuhi kūikawā ma mua o ka hoʻohana ʻana.
P264: Holoi pono i ka ʻili ma hope o ka lawelawe ʻana.
P280: E ʻaʻahu i nā mīkina lima pale / lole pale / pale maka / pale maka.
P308 + P313: Inā ʻike ʻia a hopohopo paha: E kiʻi i ka ʻōlelo aʻo kino.
P405: Paʻa ka hale kūʻai.
ʻO Shanghai Ruifu Chemical Co., Ltd. ka mea hoʻolako alakaʻi o Chloramphenicol (CAS: 56-75-7) me ke kūlana kiʻekiʻe.ʻO Chloramphenicol kahi lāʻau antibacterial ākea ākea, ʻo ia ka koho mua no ka mālama ʻana i ka typhoid a me ka paratyphoid, ʻo ka lua, ua hoʻohana ʻia no ka mālama ʻana i nā maʻi maʻi maʻi i hoʻokumu ʻia e nā microorganism maʻalahi.Ma muli o koʻikoʻi adverse reactions ua hoʻohana emi a emi.ʻO ka spectrum antibacterial, ka hana a me ka hoʻohana ʻana e like me ka chloramphenicol no ka mālama ʻana iā Salmonella Typhi, Shigella, Escherichia coli, influenza, Brucella, nā maʻi pneumonia i hoʻokumu ʻia e ka cocci a me nā lāʻau antibiotic ʻē aʻe.Hoʻohana nui ʻia ʻo Chloramphenicol e mālama i ka maʻi urinary tract, Pneumonia, maʻi ʻōpū a me ka septicemia i hoʻokumu ʻia e ka maʻi bacteria, a me nā kulu maka waho a me nā kulu pepeiao.
UN3249 Lapaʻau, paʻa, ʻona, nos, Papa Hazard: 6.1;Lepili: 6.1-Nā mea ʻawaʻawa.UN2811 ʻO nā mea ʻawaʻawa, nā mea ola, nos, Papa Hazard: 6.1;Nā Lepili: 6.1- Nā mea ʻawaʻawa, Pono inoa ʻenehana.