DAPT (GSI-IX) CAS 208255-80-5 γ-Secretase Inhibitor Assay >98.0% (HPLC) Factory
ʻO Shanghai Ruifu Chemical Co., Ltd. ka mea hana nui o DAPT (GSI-IX) (CAS: 208255-80-5) me ke kūlana kiʻekiʻe, γ-Secretase Inhibitor.Hāʻawi ʻo Ruifu Chemical i kahi pūʻulu o nā waikawa amino a me nā derivatives.Hiki iā mākou ke hāʻawi i ka hāʻawi honua, nā mea liʻiliʻi a me ka nui i loaʻa.Kūʻai iā DAPT,Please contact: alvin@ruifuchem.com
| Inoa Kimia | DAPT |
| Nā huaʻōlelo like | GSI-IX;γ-Secretase Inhibitor IX;Gamma-Secretase Inhibitor;LY-374973;(3,5-Difluorophenylacetyl)-Ala-Phg-OtBu;(3,5-Difluorophenylacetyl)-L-Alanyl-L-2-Phenylglycine tert-Butyl Ester;N-[N-(3,5-Difluorophenacetyl)-L-Alanyl]-S-Phenylglycine t-Butyl Ester;(2S)-N-[2-(3,5-Difluorophenyl)acetyl]-L-Alanyl-2-Phenyl-glycine 1,1-Dimethylethyl Ester |
| Kūlana Kūʻai | Loaʻa |
| Helu CAS | 208255-80-5 |
| ʻĀpana Molekala | C23H26F2N2O4 |
| Kaumaha Molecular | 432.47 |
| ʻO ka mānoanoa | 1.213 g/cm3 |
| Lae hehee | 142.0~146.0 ℃ |
| Pilikino | Paʻa wela |
| Ka hikiwawe | Hiki ke hoʻoheheʻe ʻia ma DMSO |
| Waihona Temp. | E mālama i ka 2-8 ℃ |
| COA & MSDS | Loaʻa |
| Brand | Kemika Ruifu |
| Nā ʻōlelo palekana | 24/25 - Hōʻalo i ka pili ʻana me ka ʻili a me nā maka. | ||
| WGK Kelemānia | 3 | HS Code | 2922491990 |
| Nā mea | Nā Kūlana Nānā | Nā hualoaʻa |
| Ka nana aku | Keʻokeʻo a i ʻole ke keʻokeʻo Crystalline pauda | Kūlike |
| Nalo ma ka maloo | <0.40% | 0.21% |
| Koena ma ka Ignition | <0.40% | 0.20% |
| Nā Metala Kaumaha (e like me Pb) | ≤20ppm | <20ppm |
| Hana ʻIke / ʻIke | >98.0% (HPLC) | 98.62% |
| Kalapona ma ka Elemental Analysis | 62.1~64.1% | Kūlike |
| Nitrogen ma ka Elemental Analysis | 6.20-6.70% | Kūlike |
| Infrared Spectrum | Kūlike i ka hoʻolālā | Kūlike |
| NMR Spectrum | Kūlike i ka hoʻolālā | Kūlike |
| Ka hopena | ʻO kēia huahana e ka Inspection Accords me ka Enterprise Standard | |
| Ola Pahu | 24 mau mahina mai ka lā hana inā mālama pono ʻia | |
Pūʻolo: ʻO ka ʻōmole Fluorinated, ʻeke ʻeke alumini, 25kg / pahu pahu pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E kūʻai i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo, maloʻo (kūʻai ma 2-8 ℃) a me ka hale kūʻai ventilated mai nā mea like ʻole.E pale i ka malamalama a me ka wai.
Pehea e kūʻai ai?E ʻoluʻolu e kelepona maiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 mau makahiki ʻike?Loaʻa iā mākou ma mua o 15 mau makahiki o ka ʻike i ka hana ʻana a me ka hoʻokuʻu ʻana aku i kahi ākea ākea o nā intermediates pharmaceutical kiʻekiʻe a i ʻole nā kemika maikaʻi.
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DAPT (GSI-IX) (CAS: 208255-80-5), he mea hoʻopaneʻe ikaika a kūikawā o γ-secretase.ʻO DAPT kahi mea hoʻopaneʻe o γ-secretase (IC50 i nā neurons mua kanaka = 115 nM no ka huina Aβ a i ʻole 200 nM no Aβ42 kikoʻī).Ua hōʻike ʻia ka hoʻokele waha o DAPT e hōʻemi i nā pae o Aβ i loko o ka lolo, ka wai cerebrospinal a me ka plasma mai nā ʻiole a me nā ʻiole.Hoʻopaʻa ʻo DAPT i ka hōʻailona Notch e hāpai ana i ka ʻokoʻa neuronal o nā cell precursor.Hoʻonui i nā pūnaewele iPS me ka ʻole oncogenes KLF4 a me CMYC5.Cell permeable.Hoʻohana ʻia ka DAPT i ke aʻo ʻana i ka hoʻokumu ʻana o β-amyloid.Ua hōʻike ʻia ʻo DAPT e kāohi i ka hōʻailona Notch i nā haʻawina o nā maʻi autoimmune a me nā maʻi lymphoproliferative, e like me ALPS a me lupus erythematosus, a me ka ulu ʻana o ka maʻi maʻi, angiogenesis, a me ka hoʻokaʻawale ʻana o nā pūnaewele pluripotent stem cell.Kāohi i ka hōʻailona Notch in vitro.Kāohi i ka huina Aβ a me Aβ42 hana i nā moʻomeheu mua o ke kanaka (ʻo 115 a me 200 nM nā helu IC50) me ka hopena ʻole o nā pae APPα a me APPβ.Paʻa ka lolo-koko.3D Growth matrix component a me ka mea o ka cerebral organoid differentiation media.
