Daptomycin CAS 103060-53-3 Maʻemaʻe ≥95.0% API Factory Maʻemaʻe Kiʻekiʻe

ʻO Daptomycin (CAS: 103060-53-3) kahi ʻano lāʻau antibiotic cyclic lipopeptide me ka hoʻolālā hou.Lawe ʻia ia mai ka Streptomyces fermentation broth.Ua ʻike ʻia e Eli Lilly Company i ka makahiki 1980, a ua hoʻomohala maikaʻi ʻia ma 1997 e Cubist Pharmaceuticals.ʻAʻole wale ka loaʻa ʻana o kahi ʻano kemika hou akā aia kekahi ʻano hana ʻokoʻa mai nā lāʻau antibiotic i ʻae ʻia ma mua: ke kāohi nei ia i ka cell ma o ka hoʻopau ʻana i ka lawe ʻana o nā amino acids ma o ka membrane cell, no laila ke kāohi nei i ka biosynthesis peptidoglycan wall cell a hoʻololi i ke ʻano o ka membrane pūnaʻi.Hiki iā ia ke hoʻopau i ka hana o ka membrane cell bacteria ma nā ʻano he nui, a pepehi koke i ka hua bacteria gram-positive.Ma waho aʻe o ka hana o ka lawe ʻana i ka hopena i ka nui o nā bacteria gram-positive e pili ana i ka maʻi, ʻoi aku ka mea nui, ʻo Daptomycin ka mana ikaika i ka mālama ʻana i nā ʻano kaʻawale i hōʻike i nā hōʻailona o ke kū'ē i ka methicillin, vancomycin a me linezolid.He koʻikoʻi koʻikoʻi kēia waiwai i nā poʻe maʻi e loaʻa ana i ka maʻi koʻikoʻi.I Kepakemapa 2003, ua ʻae ka US Food and Drug Administration no ka manawa mua i hiki ke hoʻohana ʻia ʻo Daptomycin (CAS: 103060-53-3) no ka mālama ʻana i nā maʻi ʻili koʻikoʻi.I Malaki 2006, ua ʻae ʻia no ka mālama ʻana i nā maʻi maʻi.I Ianuali 2006, ua ʻae ʻia e ke Komisina ʻEulopa no ka mālama ʻana i kekahi mau maʻi paʻakikī o ka ʻili a me nā ʻiʻo palupalu i hoʻokumu ʻia e ka maʻi bacteria gram-positive.Ma ka lā 6 o Kepakemapa, 2007, ua hoʻolaha ʻo Cubist Pharmaceuticals ua ʻae ka European Union i kāna lāʻau antibacterial, Cubicin no ka mālama ʻana i ka endocarditis puʻuwai akau i hoʻokumu ʻia e nā maʻi Staphylococcus aureus a me nā maʻi paʻakikī o ka ʻili a me nā maʻi palupalu e pili ana i ka Staphylococcus aureus.