Decitabine CAS 2353-33-5 Maʻemaʻe >99.5% (HPLC) Hale Hana
ʻO Shanghai Ruifu Chemical Co., Ltd. ka mea hana nui a me ka mea hoʻolako o Decitabine (CAS: 2353-33-5) me ke ʻano kiʻekiʻe.Hiki iā mākou ke hāʻawi i ka COA, ka lawe ʻana i ka honua holoʻokoʻa, nā mea liʻiliʻi a me ka nui i loaʻa.Inā makemake ʻoe i kēia huahana, e ʻoluʻolu e hoʻouna i ka ʻike kikoʻī e pili ana i ka helu CAS, ka inoa huahana, ka nui iā mākou.Please contact: alvin@ruifuchem.com
| Inoa Kimia | Decitabine |
| Nā huaʻōlelo like | 5-Aza-2'-Deoxycytidine;5-Aza-1-(2-Deoxy-β-D-Ribofuranosyl)cytosine;5-Aza-CdR;5-Aza-dC;5-Deoxy-2'-Azacytidine;ZdCyd;DAC;β-Decitabine |
| Helu CAS | 2353-33-5 |
| Helu CAT | RF2728 |
| Kūlana Kūʻai | Ma ka waihona, hoʻonui ʻia a hiki i nā tona |
| ʻĀpana Molekala | C8H12N4O4 |
| Kaumaha Molecular | 228.21 |
| Lae hehee | 191℃ (Dek.) |
| Pilikino | Paʻi Lewa, Paʻa Wela |
| Ka hikiwawe | Hoʻopau ʻia ma DMSO;Hiki i ka wai |
| Brand | Kemika Ruifu |
| 'ikamu | Nā kikoʻī |
| Ka nana aku | Keʻokeʻo a i ʻole ke keʻokeʻo Crystalline pauda |
| ʻIkepili A | IR: Kūlike ka La'ana IR Spectrum me kēlā o ke Kūlana |
| ʻIkepili B | HPLC: ʻO ka RT o ka Puʻupuʻu Nui o ka Ho'āʻo Ho'āʻo e pili ana i kēlā o ka Hoʻoponopono Maʻamau |
| ʻIkepili C | PXRD: Pono |
| Maʻemaʻe / Kaʻina Hanana | >99.5% (HPLC) |
| Alpha | +56.0°~ 63.0° |
| Nalo ma ka maloo | <0.50% |
| Koena ma ka Ignition | <0.10% |
| Nā Metala Kaumaha | <20ppm |
| Na mea pili | |
| α-Decitabine | <0.20% |
| Hoʻokahi i ʻike ʻole ʻia ka haumia | <0.20% |
| Huina paumaele | <0.50% |
| Nā mea hoʻoheheʻe koena | |
| DMSO | <0.50% |
| Methanol | <0.30% |
| Methyl Formate | <0.05% |
| Acetonitrile | <0.041% |
| Ka hikiwawe | Maʻemaʻe kala ʻole 50 mg/ml, HOAc a me H2O (1:1) Pass |
| Kūlana hoʻāʻo | Kūlana ʻoihana |
Pūʻolo: ʻOmole, ʻeke ʻeke Aluminum, 25kg / pahu pahu pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;E pale i ka malamalama a me ka wai
Pehea e kūʻai ai?Please contact: sales@ruifuchem.com or alvin@ruifuchem.com
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Hooia Hale Hana?Welina mai ka loiloi hale hana.E ʻoluʻolu e hoʻopaʻa manawa ma mua.
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Decitabine (CAS: 2353-33-5) (inoa kālepa Dacogen), a i ʻole 5-Aza-2'-Deoxycytidine.ʻO ke kemika, he analog cytidine.ʻO Decitabine kahi mea hana hypomethylating.Ua hoʻokuʻu ʻia ʻo Decitabine no ka mālama ʻana i nā maʻi myelodysplastic (MDS).ʻO MDS kahi pūʻulu o nā maʻi hematologic e pili ana i ka iwi iwi e hopena i ka hoʻokumu ʻana a me ka hoʻomohala ʻana o nā ʻāpana koko.Eia kekahi, hiki i nā poʻe maʻi me MDS ke piʻi nui i ka maʻi leukemia myeloid acute (AML).ʻO nā lāʻau maʻamau e pili ana i ka hoʻokahe koko, nā kumu ulu hematopoietic, a me nā antibiotic prophylactic, akā hoʻomaikaʻi wale kēia mau ana i ka maikaʻi o ke ola me nā hopena kānalua i ka hoʻololi ʻana i ka maʻi.ʻOiai ʻo ka hoʻololi ʻana i ka stem-cell he hana koʻikoʻi, hiki ke hoʻōla ʻia, ʻo ka ʻelemakule a i ʻole nā pilikia olakino paʻakikī o ka hapa nui o nā maʻi e pale iā lākou mai ka noʻonoʻo ʻana i kēia koho.ʻO nā holomua hou i ka etiology kumu o MDS, akā naʻe, ua alakaʻi i ka hoʻomohala ʻana i kahi papa hou o nā pūhui i kapa ʻia ʻo "demethylating agents".Ke hahai nei ʻo Decitabine i ka hoʻomaka ʻana o ka DNA methyltransferase inhibitor Azacitidine mua.ʻO ia ka hypomethylates DNA ma ke kāohi ʻana i ka DNA methyltransferase.Hoʻohana like ia me Azacitidine, ʻoiai hiki ke hoʻopili wale ʻia ka decitabine i loko o nā kaula DNA a hiki i ka azacitidine ke hoʻokomo i nā kaulahao DNA a me RNA.Nā mea hoʻopaneʻe noiʻi: Hoʻohana nui ʻia ka Decitabine i ka molecular biology, pharmacology, a me nā noiʻi ʻepekema ʻē aʻe.ʻO Decitabine ma ke ʻano he DNA methyltransferase inhibitor, hoʻihoʻi ʻia ke kaʻina hana methylation DNA, hoʻokomo i nā ʻōpū maʻamau i nā cell maʻamau e hoʻokaʻawale a hoʻoulu paha i ka apoptosis cell tumor.E ʻoluʻolu e hoʻomanaʻo e pāʻani ke ʻano kiʻekiʻe o Decitabine i kona hopena cytotoxic: hiki ke pale i ka DNA synthesis induced cell death.
