Diethylphosphonoacetic Acid CAS 3095-95-2 Maʻemaʻe >99.5% (HPLC) Afatinib Dimaleate Intermediate Factory
ʻO Ruifu Nā Kūwaena Hoʻolako Kimia o Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-hoʻokahi CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl) oxy)quinazolin-4-AmineCAS 314771-88-5
Inoa Kimia | Diethylphosphonoacetic Acid |
Nā huaʻōlelo like | 2-(Diethoxyphosphoryl)acetic Acid;(Diethoxyphosphinyl)acetic Acid;Diethyl Carboxymethylphosphonate;NSC 272281 |
Helu CAS | 3095-95-2 |
Helu CAT | RF-PI2024 |
Kūlana Kūʻai | Ma ka waihona, ka mana hana 30MT / mahina |
ʻĀpana Molekala | (C2H5O)2P(O)CH2CO2H |
Kaumaha Molecular | 196.14 |
Lae paila | 150 ℃/0.05 mmHg (māmā) |
ʻO ka mānoanoa | 1.220 g/mL ma 25 ℃ (māmā) |
Hōʻike Hōʻike | n20/D 1.445 (māmā) |
Brand | Kemika Ruifu |
'ikamu | Nā kikoʻī |
Ka nana aku | Wai kala ʻole |
ʻIkepili (HPLC) | ʻO ka manawa paʻa o ka piko nui i loaʻa mai ka hāpana i loko o 5% o ka hāpana kuhikuhi. |
Maʻemaʻe / Kaʻina Hanana | >99.5% (HPLC) |
Infrared Spectrum | Kūlike i ka hoʻolālā |
Proton NMR Spectrum | Kūlike i ka hoʻolālā |
Māmā (KF) | <0.50% |
Huina paumaele | <0.50% |
Kūlana hoʻāʻo | Kūlana ʻoihana |
Hoʻohana | Waena o Afatinib Dimaleate (CAS: 850140-73-7) |
Pūʻolo: Fluorinated Bottle, 25kg/ Drum, a i ʻole e like me ka makemake o ka mea kūʻai aku
Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;E pale i ka malamalama a me ka wai
![1](https://a395.goodao.net/uploads/15.jpg)
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Diethylphosphonoacetic Acid (CAS: 3095-95-2), Hana ma ke ʻano he nucleophile no nā ʻano hoʻohui nucleophilic no ka synthesis o allene epoxides Reactant no: Stereoselectivity study of the Staudinger reaction;Hoʻokumu enantioselective o nā diols ma o ka epoxidation a me ka hydration reactions;Nā hopena o Horner-Wadsworth-Emmons;Hoʻonohonoho hou ʻia ka chelation mamao ʻo Ireland-Claisen;ʻO nā pane ʻo Ugi-Dieckmann no ka hoʻohui ʻana i nā derivatives waikawa tetramic;Hoʻohana ʻia e hana i nā phosphonoester intermediates no intramolecular HEW reactions.ʻO ka Diethylphosphonoacetic Acid kahi mea waena o Afatinib Dimaleate (CAS: 850140-73-7).Ua ʻae ʻia ʻo Afatinib Dimaleate e ka US Food and Drug Administration (FDA) i ka makahiki 2013 no ka mālama ʻana i ka maʻi maʻi ʻaʻai liʻiliʻi liʻiliʻi (NSCLC).Ma keʻano kikoʻī, ua ʻae ʻia ia no nā mea maʻi e hōʻike ana me nā ʻōpū NSCLC metastatic i loaʻa i ka epidermal growth factor receptor (EGFR) exon deletions a i ʻole exon 21 mutations.ʻO Afatinib Dimaleate kahi mea hoʻopaneʻe kovalent o ErbB tyrosine kinases (tyk), ka mea e hoʻohaʻahaʻa i ka hōʻailona ErbB ma o ka hoʻopaʻa ʻole ʻana o nā pūnaewele pili EGFR tyk.
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