Entecavir CAS 142217-69-4 API Hale Hana Kiʻekiʻe Anti-HBV
Hāʻawi Mea Hana me ka Maʻemaʻe kiʻekiʻe a me ka maikaʻi paʻa
Inoa Kemika: Entecavir
CAS: 142217-69-4
Hoʻohana ʻia ka lāʻau antiviral i ka mālama ʻana i ka maʻi Hepatitis B
API no ke kūlana kiʻekiʻe, hana kālepa
Inoa Kimia | Entecavir |
Nā huaʻōlelo like | 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one |
Helu CAS | 142217-69-4 |
Helu CAT | RF-API80 |
Kūlana Kūʻai | Ma ka waihona, ʻoi aku ka nui o ka hana a hiki i nā haneli kilogram |
ʻĀpana Molekala | C12H15N5O3 |
Kaumaha Molecular | 277.28 |
Lae hehee | 249.0~252.0 ℃ |
Brand | Kemika Ruifu |
'ikamu | Nā kikoʻī |
Ka nana aku | Pauda Crystal Keʻokeʻo |
ʻIkepili IR | Pono e kūlike ka spectrum absorption infraed o ka laʻana hoʻāʻo me ka maʻamau kuhikuhi |
ʻIke HPLC | ʻO ka manawa paʻa o ka hāpana hoʻāʻo e pili ana i ka maʻamau kuhikuhi |
pH | 5.5-7.5 |
Hoʻololi Optical kikoʻī | +24.0°-+28.0° (DMF: MeOH=1:1 C=1%) |
Na mea pili | |
Huina paumaele | ≤0.30% |
ʻO ka haumia hoʻokahi kiʻekiʻe | ≤0.10% |
Enantiomer | ≤0.20% |
Nā mea hoʻoheheʻe koena | |
Methanol | ≤0.30% |
Dichloromethane | ≤0.06% |
n-Hexane | ≤0.029% |
Tetrahydrofuran | ≤0.072% |
N,N-Dimethylformamide | ≤0.088% |
Toluene | ≤0.089% |
Waiwai | 5.8%~6.5% |
Koena ma ka Ignition | ≤0.10% |
Nā Metala Kaumaha | ≤20ppm |
Hoʻāʻo | 98.0%~102.0% (C12H15N5O3 helu ʻia ma ke kumu anhydrous) |
Ka nui o ka ʻāpana | D90: ≤100µm |
Kūlana hoʻāʻo | Kūlana ʻoihana |
Hoʻohana | API, lāʻau Antiviral i hoʻohana ʻia i ka mālama ʻana i ka maʻi Hepatitis B |
Pūʻolo: ʻO ka ʻōmole, ʻeke ʻeke alumini, pahu pahu pahu, 25kg / pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;Palekana mai ka malamalama, ka ma'ū a me ka pest infestation.
ʻO Entecavir kahi hanauna hou o ka guanine nucleoside analogues waha lāʻau lapaʻau no ka mālama ʻana i ka maʻi Hepatitis B (HBV), ka mea nui no ka mālama ʻana i nā poʻe maʻi maʻi me ka hana hoʻopiʻi viral a me ka serum transaminase e hoʻomau i ka hoʻonui, a i ʻole ka ʻiʻo ate no ka hana pathological o ka hepatitis B mau loa. , i kēia manawa i lalo virus ka wikiwiki a me ka ikaika loa, ka mutation rate haʻahaʻa nucleoside analogues.Hōʻike ka ʻikepili i nā mea maʻi me ka maʻi hepatitis B, me ka nucleoside naive a me ka nucleoside i mālama ʻia a me nā maʻi cirrhosis ate, me ka hoʻohana ʻana i nā papa entecavir maikaʻi i ka mālama ʻana hiki ke hoʻomalu i ka maʻi wikiwiki a maʻalahi i ka mālama ʻana i ka hopena ʻoiaʻiʻo, ʻo ia hoʻi ka maʻi hepatitis B ʻaʻole i ana;ma o ka mālama ʻana i ka lāʻau lapaʻau, hiki i kahi hapa nui o nā mea maʻi ke hōʻea i ka hopena o ka ʻoluʻolu o ka mālama ʻana, ʻo ia hoʻi ka hoʻololi ʻana o ka antigen serology, hiki i kekahi mau mea maʻi ke hiki i ka mea kūpono no ka mālama ʻana i ka hopena, ʻo ia hoʻi ka antigen negative.