Entecavir Monohydrate CAS 209216-23-9 API Hale Hana Ki'eki'e Hepatitis B
Hāʻawi Mea Hana me ka Maʻemaʻe kiʻekiʻe a me ka maikaʻi paʻa
Inoa Kemika: Entecavir Monohydrate
CAS: 209216-23-9
Hoʻohana ʻia i ka mālama ʻana i ka maʻi Hepatitis B
API no ke kūlana kiʻekiʻe, hana kālepa
Inoa Kimia | Entecavir Monohydrate |
Nā huaʻōlelo like | Entecavir Hydrate;9-[(1S,3R,4S)-4-Hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]guanine Monohydrate |
Helu CAS | 209216-23-9 |
Helu CAT | RF-API79 |
Kūlana Kūʻai | Ma ka waihona, ʻoi aku ka nui o ka hana a hiki i nā haneli kilogram |
ʻĀpana Molekala | C12H17N5O4 |
Kaumaha Molecular | 295.3 |
Lae hehee | >220 ℃ |
ʻO ka mānoanoa | 1.81 |
Kūlana Hoʻouna | Hoʻouna ʻia ma lalo o ka wela ambient |
Brand | Kemika Ruifu |
'ikamu | Nā kikoʻī |
Ka nana aku | Keʻokeʻo a ʻaneʻane keʻokeʻo Crystalline pauda |
Ka hikiwawe | Hiki ke hoʻoheheʻe ʻia i loko o ka Dimethylformamide, hiki ke hoʻoheheʻe ʻia i ka wai, ethanol a me ka methanol |
ʻIkepili IR | Kūlike ke kiko o ka hāpana me ka maʻamau kuhikuhi |
ʻIke HPLC | ʻO ka manawa paʻa o ka hāpana hoʻāʻo e pili ana i ka maʻamau kuhikuhi |
Waiwai (na KF) | 5.5%~6.5% |
Hoʻololi Optical kikoʻī | +24.0° a i +30.0° (DMF: MeOH=1:1 C=1%) (ma ka mea anhydrous) |
Koena ma ka Ignition | ≤0.10% |
Na mea pili | |
ʻO Furoentecavir | ≤0.10% |
Entecavir 1-Epimer | ≤0.10% |
Entecavir 3-Epimer | ≤0.10% |
8-Methyoxy Entecavir | ≤0.10% |
Entecavir 4-Epimer | ≤0.10% |
8-Hydroxy Entecavir | ≤0.10% |
4-Dimethylsilyl Entecavir | ≤0.10% |
Entecavir Huihui Pili A | ≤0.10% |
ʻO nā mea haumia ʻole i hōʻike ʻia | ≤0.10% |
Huina paumaele | ≤0.30% |
Nā mea hoʻoheheʻe koena | |
Methanol | ≤600ppm |
Dichloromethane | ≤300ppm |
Ethyl Acetate | ≤1000ppm |
Tetrahydrofuran | ≤720ppm |
Toluene | ≤890ppm |
Benzyl Chloride | ≤1000ppm |
Benzyl Alcohol | ≤1000ppm |
Palena Microbial | |
Huina Aerobic | ≤100cfu/g |
Huna a me ka Molds | ≤10cfu/g |
Escherichia Coli | ʻAʻole pono e ʻike ʻia |
Nā Metala Kaumaha | ≤10ppm |
Hoʻāʻo | 98.0%~102.0% (HPLC; ma ke kumu anhydrous) |
Ka nui o ka ʻāpana | Pono ka 95% o nā ʻāpana i loko o 125um |
Kūlana hoʻāʻo | ʻOihana Kūlana;ʻAmelika Hui Pū ʻIa Pharmacopoeia (USP). |
Hoʻohana | Hoʻohana ʻia ka lāʻau antiviral i ka mālama ʻana i ka maʻi Hepatitis B |
Pūʻolo: ʻO ka ʻōmole, ʻeke ʻeke alumini, pahu pahu pahu, 25kg / pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;Palekana mai ka malamalama, ka ma'ū a me ka pest infestation.
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ʻO ka Entecavir Monohydrate (CAS 209216-23-9) he lāʻau antiviral waha i hoʻohana ʻia i ka mālama ʻana i ka maʻi Hepatitis B (HBV).ʻO ka Entecavir Monohydrate kahi analog nucleoside (ʻoi aku ka kikoʻī, kahi analogue guanine) e kāohi ana i ka hoʻohuli ʻana, ka hoʻopiʻi DNA a me ka transcription i loko o ka vira.He ʻano hou ia o ka cyclopentyl acyl guanosine anti-Hepatitis B nā lāʻau maʻi me kona hopena lāʻau lapaʻau e like me Entecavir.Hoʻohana ʻia ia i ka mālama ʻana i ka maʻi Hepatitis B maʻi maʻi i loaʻa i ka hoʻopiʻi viral ikaika, hoʻonui i ka serum transaminase ALT a i ʻole nā ʻeha ikaika i hōʻike ʻia mai ka histology o ka ate.ʻO ka Entecavir Monohydrate he mea hoʻopaneʻe ikaika a koho i ka HBV, me kahi EC50 o 3.75 nM i loko o ka cell HepG2.ʻO Entecavir kahi mea hoʻopaneʻe transcriptase.Kāohi ia i ka Hepatitis B Virus (HBV) mai ka hoʻonui ʻana a hoʻemi i ka nui o ka maʻi maʻi i loko o ke kino.
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