Flurbiprofen CAS 5104-49-4 Hōʻike 99.0~100.5% (HPLC) Hale Hana

Flurbiprofen
C15H13FO2 244.27
(±)-2-(2-Fluoro-4-biphenylyl)propionic acid [5104-49-4].
Aia ka Flurbiprofen ma lalo o 99.0 pakeneka a ʻaʻole i oi aku ma mua o 100.5 pakeneka o C15H13FO2, i helu ʻia ma ke kumu maloʻo.
Hoʻopili a mālama ʻia - mālama i loko o nā pahu paʻa.
Nā kūlana hōʻike USP <11>-
USP Flurbiprofen RS
USP Flurbiprofen Huina Pili A RS
2-(4-Biphenylyl)ʻakika propionic.
C15H14O2 226.28
ʻike-
A: Infrared Absorption <197K>.
B:Ultraviolet Absorption 197U-
Pane: 10 µg no mL.
Medium: 0.1 N sodium hydroxide.
ʻO ke kiʻekiʻe loa ma ka 247 nm ma kahi o 0.8.
Māhele heheʻe <741>: ma waena o 114 a me 117.
Nalo ma ka maloo <731>-Moloolo ia i loko o ka momi ma 60 a hiki i ke kaumaha mau: ʻaʻole e nalowale ma mua o 0.5% o kona kaumaha.
ʻO ke koena ma ka ʻā ʻana <281>: ʻaʻole ʻoi aku ma mua o 0.1%.
Nā metala kaumaha, Keʻano II <231>: 0.001%.
Huipuia pili-
Diluent-Hoʻomākaukau i kahi hui o ka wai a me ka acetonitrile (11: 9).
ʻĀpana paʻa-E hoʻomākaukau i kahi hui ʻana o ka wai, acetonitrile, a me glacial acetic acid (12:7:1).Hana i nā hoʻololi inā pono (e nānā i ka System Suitability ma lalo o Chromatography <621>).
ʻO ka hoʻonā waiwai maʻamau- E hoʻoheheʻe i ka nui o ka USP Flurbiprofen Related Compound A RS i ka Diluent no ka loaʻa ʻana o kahi hoʻonā i loaʻa ka ʻike ma kahi o 50 µg no mL.
ʻO ka hoʻonā kūpono o ka ʻōnaehana-Pipet 2.0 mL o ka solution stock Standard i loko o kahi pahu volumetric 10-mL, hoʻohui i kahi 20 mg o USP Flurbiprofen RS, hoʻoheheʻe me ka Diluent i ka leo, a hui pū.
ʻO ka hoʻonā maʻamau-E hoʻoneʻe i 2.0 mL o ka hopena waihona maʻamau i kahi pahu volumetric 10.0-mL, e hoʻoheheʻe me ka Diluent i ka leo, a hui.
ʻO ka hopena ho'āʻo-E hoʻomākaukau i kahi hopena o Flurbiprofen i loko o ka Diluent i loaʻa ka 2.0 mg no ka mL.
Pūnaehana Chromatographic (e nānā i ka Chromatography <621>)-Ua hoʻolako ʻia ka chromatograph wai me kahi mea ʻike 254-nm a me kahi kolamu 3.9-mm × 15-cm i loaʻa iā 4-µm packing L1.ʻO ka nui o ke kahe e pili ana i 1 mL i kēlā me kēia minuke.Chromatograph i ka hoʻonā kūpono Pūnaehana, a hoʻopaʻa i nā pane kiʻekiʻe e like me ke kuhikuhi ʻia no ke Kaʻina Hana: ʻo nā manawa paʻa pili ma kahi o 0.9 no ka hui pili Flurbiprofen A a me 1.0 no flurbiprofen;a ʻaʻole ʻoi aku ma mua o 1.0% ka hoʻokaʻawale maʻamau no ka hoʻopili hou ʻana.
Ke Kaʻina Hana-E hoʻokaʻawale i nā puke like (ma kahi o 20 µL) o ka solution Standard a me ka solution Test i loko o ka chromatograph, e hoʻopaʻa i nā chromatograms, a e ana i nā wahi no nā piko nui.E helu i ka pākēneka o flurbiprofen pili pūhui A ma ka hapa o Flurbiprofen i lawe ʻia e ke kumu:
100(CS / CU)(rU / rS)
ʻo ia ka CS ka hoʻopaʻa ʻana, ma µg per mL, o ka USP Flurbiprofen Related Compound A RS i ka hoʻonā maʻamau;ʻO CU ka hoʻopaʻa ʻana, ma µg per mL, o Flurbiprofen i loko o ka hoʻonā Hoʻāʻo;a ʻo rU a me rS nā pane kiʻekiʻe no ka flurbiprofen pili pūhui A i loaʻa mai ka hopena hoʻāʻo a me ka solution maʻamau, kēlā me kēia: ʻaʻole i ʻoi aku ma mua o 0.5% o ka pūhui pili flurbiprofen A loaʻa.E helu i ka pākēneka o kēlā me kēia haumia i ka ʻāpana o Flurbiprofen i lawe ʻia e ke kumu:
100(ri / rs)
i loko o ka ri ka pane kiʻekiʻe no kēlā me kēia haumia i loaʻa mai ka hopena Ho'āʻo;a ʻo rs ka huina o nā pane o nā piko a pau i loaʻa mai ka hoʻonā Hoʻāʻo: ʻaʻole ʻoi aku ka nui o nā haumia a pau ma mua o 1.0%.
Assay-Dissolve ma kahi o 0.5 g o Flurbiprofen, i kaupaona pono, i loko o 100 mL o ka waiʻona, i hoʻokaʻawale mua ʻia me 0.1 N sodium hydroxide VS i ka phenolphthalein endpoint, e hoʻohui i ka phenolphthalein TS, a titrate me 0.1 N sodium hydroxide VS i ka ʻike mua ʻana o kahi mea maule. kala ʻulaʻula e mau ana no ka emi ʻole o 30 kekona.ʻO kēlā me kēia mL o 0.1 N sodium hydroxide ua like ia me 24.43 mg o C15H13FO2.