Fmoc-Ile-OH CAS 71989-23-6 Fmoc-L-Isoleucine Purity >99.0% (HPLC) Hale Hana

ʻO Fmoc-L-Isoleucine (Fmoc-Ile-OH) (CAS: 71989-23-6) he isoleucine derivative, he waikawa amino kūlohelohe i hoʻohana ʻia no nā peptidomimetics.ʻO ka Fmoc-L-isoleucine he Nα-9-fluorenylmethoxycarbonyl-amino acid.ʻO 9-fluorenylmethoxycarbonyl kahi hui pale amino koʻikoʻi i ka peptide synthesis.No ka mea he pūʻulu hoʻomalu koʻikoʻi kumu a paʻa i nā kūlana i hoʻohana ʻia e wehe i nā pūʻulu pale maʻamau, he kuleana kūʻokoʻa ia i ka synthesis polypeptide.Paʻa hale maʻamau no ka hana maʻamau peptide synthesis ma hope o ka Fmoc-tactics.
ʻO Fmoc-amino acids, hoʻohana ʻia i ka peptide synthesis, hoʻohana ʻia ma ke ʻano he mea hoʻohuihui kūlohelohe, waena lāʻau lapaʻau, biochemical reagent a i ʻole reagent kemika.
Hoʻomākaukau L-Isoleucine (CAS: 73-32-5) 1.05g (0.008 mol) o ka paʻa i hoʻoheheʻe ʻia i ka 10% sodium carbonate solution, L-isoleucine paʻa ua lawa ka hoʻoheheʻe ʻia e ka hoʻoulu ʻana.Ma 20 ~ 30 ℃, 9-fluorenylmethoxycarbonyl chloride (205g) i hoʻoheheʻe ʻia i toluene (2 ~ 2.10) i hoʻohui ʻia i ka dropwise, 0.008 mol) hoʻonā, Dropwise hoʻohui i 30 ~ 60 mau minuke, ka hopena o ka hoʻohui, ma 20 ~ 30 C hoʻoulu 1 ~ 8 hola, hoʻohui i 30 ~ 200 ml o ka wai dilution, me ka n-butyl acetate (80 ml) oi aku 9-fluorenylmethoxycarbonyl chloride ua wehe 'ia e ka extraction, ka hopena aqueous pae ua acidified me ka concentrated hydrochloric acid i PH = 0.5 ~ 3.5, laila. unuhi ʻia me ka n-butyl acetate (80 ml), a holoi ʻia ka hopena aila me ka wai e wehe i ka waikawa hydrochloric, ua hoʻopaʻa ʻia ka ʻaila aila e wehe i ka solvent n-butyl acetate, ua hoʻokahe ʻia nā kristal keʻokeʻo, kānana a maloʻo e hāʻawi i ka huahana. Fmoc-L-Isoleucine 2.48g, hua 87.9%, Heehee Point: 140.0 ~ 155.0 ℃.