Fondaparinux Sodium CAS 114870-03-0 API
Hoʻolako me ka maʻemaʻe kiʻekiʻe a me ka maikaʻi paʻa
Inoa Kemika: Fondaparinux Sodium
CAS: 114870-03-0
He Antithrombotic Anticoagulant, he mea pale Xa
API no ke kūlana kiʻekiʻe, hana kālepa
Inoa Kimia | Fondaparinux Sodium |
Helu CAS | 114870-03-0 |
Helu CAT | RF-API84 |
Kūlana Kūʻai | Ma ka waihona, ʻoi aku ka nui o ka hana a hiki i nā haneli kilogram |
ʻĀpana Molekala | C31H43N3O49S8.10Na |
Kaumaha Molecular | 1728.08 |
Brand | Kemika Ruifu |
'ikamu | Nā kikoʻī |
Ka nana aku | Keʻokeʻo a hiki i ka pauda keʻokeʻo |
Hana ʻIke / ʻIke | 95.0%~103.0% (ma ke kumu maloʻo) |
Ka hikiwawe | Hiki ke hoʻoheheʻe ʻia i ka wai, 2.0M Sodium Chloride a me 0.5M Sodium Hydroxide a hiki ʻole i ka Ethanol. |
ʻIkepili 13C-NMR | Pono e nānā ʻia nā Resonances no Fondaparinux Sodium ma 58.2, 29.5, 60.5, 60.8, 68.9, 69.2, 69.6, 98.9, 100.4, 101.1, 102.4, 103.9, 176.7 a me 176.7.ʻAʻole ʻokoʻa nā hoʻololi kemika o kēia mau hōʻailona ma mua o ± 0.3ppm nā hōʻailona ʻē aʻe o nā kiʻekiʻe kiʻekiʻe a me nā hoʻololi kemika, pili i ka Fondaparinux Sodium, ʻike ʻia paha ma waena o 58.0~80.5 ppm a me 98.7~104.5ppm |
ʻIke HPLC | ʻO ka manawa paʻa o ka piko nui o ka hāpana hāpana e pili ana i ka hopena maʻamau |
ʻIkepili AAS | Pono ka Sodium i ka absorption ma 330.2nm ma lalo o ka hoʻoholo ʻana o ka sodium |
pH | 6.0~8.0 |
Sodium (Na) | 11.5% ~ 15.0% (I helu ʻia ma ka anhydrous a me nā solvents manuahi) |
Sulfate noa | ≤0.30% |
Ke koena Chloride | ≤1.00% |
Na mea pili | |
haumia A | ≤0.80% |
haumia B | ≤0.60% |
Hoʻokahi 'ē aʻe haumia | ≤0.30% |
Huina paumaele | ≤2.00% |
Nā mea hoʻoheheʻe koena | |
Methanol | ≤3000ppm |
Ethanol | ≤5000ppm |
Ethyl Acetate | ≤5000ppm |
DMF | ≤880ppm |
Methylbenzene | ≤890ppm |
Pyridine | ≤50ppm |
Waiwai (KF) | ≤15.0% |
Nā Endotoxins Bacterial | ≤3.3EU/mg |
Palena Microbial | ʻO ka nui o nā Microorganisms ≤100cfu/g |
Kūlana hoʻāʻo | ʻOihana Kūlana;ʻAmelika Hui Pū ʻIa Pharmacopoeia (USP). |
Hoʻohana | API, He Antithrombotic Anticoagulant, he Factor Xa Inhibitor |
Pūʻolo: ʻO ka ʻōmole, ʻeke ʻeke alumini, pahu pahu pahu, 25kg / pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;Palekana mai ka malamalama, ka ma'ū a me ka pest infestation.
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ʻO Fondaparinux Sodium (CAS 114870-03-0) ka mea mua o ka papa hou o ka antithrombotic anticoagulant kemika pili i nā heparins haʻahaʻa molecular weight (LMWH).ʻO Fondaparinux sodium kahi mea Xa inhibitor e hoʻokumu i ka pae hoʻopaʻa kiʻekiʻe no ka anti-coagulant factor antithrombin III (ATIII).ʻO ka paʻa ʻana o ka sodium Fondaparinux ma kēia pūnaewele e hoʻoikaika i ka hopena inhibitory kūlohelohe o ATIII e kūʻē i ka factor Xa ma kahi o 300, e hopena i ka pale ʻana i ka hanauna thrombin.Kūʻai ʻia e GlaxoSmithKline.Ua kūʻai ʻia kahi mana maʻamau i kūkulu ʻia e Alchemia i loko o ka US e Dr. Reddy's Laboratories.Ua hoʻokomo mua ʻia ka sodium Fondaparinux i ka US no ka prophylaxis o ka thrombosis vein hohonu e hiki ke alakaʻi i ka embolism pulmonary ma hope o ke kaʻina orthopedic nui.ʻO kēia molekele synthetic holoʻokoʻa he kope ia o ka heparin pentasaccharide sequence, ʻo ka ʻāpana pōkole loa e hiki ke hoʻokaʻawale i ka antithrombin lllmediated inhibition o ka mea Xa a laila e kāohi ai i ka hana thrombin me ka hana antithrombin.
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