ʻO Gemcitabine CAS 95058-81-4 Hōʻike 98.0 ~ 102.0%

ʻO Gemcitabine (CAS: 95058-81-4) kahi lāʻau lapaʻau i hoʻohana ʻia no ka mālama ʻana i kekahi mau ʻano o ka maʻi kanesa.Hoʻopili kēia i ka maʻi ʻaʻai umauma, ka maʻi maʻi ʻaʻa ʻole liʻiliʻi liʻiliʻi, ka maʻi ʻaʻai pancreatic, ka maʻi ʻaʻai ʻākea, a me ka maʻi maʻi ʻāpana biliary.Ke noiʻi ʻia nei ʻo Gemcitabine no ka hoʻohana ʻana i ka maʻi maʻi esophageal, a hoʻohana ʻia i ka hoʻokolohua ʻana i nā lymphomas a me nā ʻano maʻi ʻē aʻe.Hoʻohana ʻia ʻo Gemcitabine ma ke ala intravenous, no ka mea, ua hoʻololi nui ʻia e ka ʻōpū o ka ʻōpū.
ʻO Gemcitabine kahi analogue nucleotide, nona ka papa anti-metabolic o nā lāʻau anticancer.Hana nui ia ma ka pae synthesis DNA, ʻo ia hoʻi, ka pae S.Ma lalo o kekahi mau kūlana, hiki iā ia ke pale i ka pae G1 mai ka holomua ʻana i ka pae S.Loaʻa iā ia nā hiʻohiʻona o ka laulā anticancer spectrum, ʻano hana kūʻokoʻa o ka hana, haʻahaʻa haʻahaʻa, ʻaʻohe kūʻē kūʻē i nā lāʻau lapaʻau chemotherapy ʻē aʻe a ʻaʻohe superposition o ka toxicity.Ua ʻae ʻia ʻo Chemicalbook, gemcitabine, no ka hoʻohana ʻana i nā ʻāina ʻoi aku ma mua o 90, e hana ana ia i ka lāʻau lapaʻau mua no ka maʻi maʻi ʻaʻai liʻiliʻi liʻiliʻi a me ka "standard gula" no ka maʻi maʻi pancreatic.
I ka makahiki 1999, ua ʻae ʻo CFDA i ka gemcitabine no ka mālama ʻana i ka NSCLC kiʻekiʻe a i ʻole metastatic NSCLC, kūloko a i ʻole metastatic pancreatic cancer;I ka makahiki 2010, ua ʻae ʻo CChemicalbookFDA i ka gemcitabine i hui pū ʻia me ka paclitaxel no ka mālama ʻana i ka maʻi maʻi maʻi ʻaʻole hiki ke hoʻokaʻawale ʻia, kūloko a i ʻole metastatic ka umauma umauma i hoʻi hou ma hope o ka adjuvant/neoadjuvant chemotherapy.
ʻO Gemcitabine kahi antimetabolite ākea ākea a me ka deoxycytidine analogue me ka hana antineoplastic.Ma ka lawelawe ʻana, hoʻololi ʻia ka gemcitabine i loko o nā metabolites ikaika difluorodeoxycytidine diphosphate (dFdCDP) a me difluorodeoxycytidine triphosphate (dFdCTP) e deoxycytidine kinase.Ua hoʻokūkū ʻo dFdCTP me ka deoxycytidine triphosphate (dCTP) a ua hoʻokomo ʻia i loko o DNA.Hoʻopaʻa kēia i ka polymerase DNA ma laila e hoʻopau ai i ka masked i ka wā o ka hoʻopiʻi DNA.Ma ka ʻaoʻao ʻē aʻe, ke kāohi nei ka dFdCDP i ka ribonucleotide reductase, a laila e hoʻemi ana i ka wai deoxynucleotide i loaʻa no ka synthesis DNA.ʻO ka hoʻemi ʻana i ka ʻike intracellular o ka dCTP potentiates i ka hoʻohui ʻana o dFdCTP i DNA.