Glimepiride CAS 93479-97-1 Assay 98.0%~102.0% API Factory Maʻemaʻe Kiʻekiʻe
Hoʻolako me ka maʻemaʻe kiʻekiʻe a me ka maikaʻi paʻa
Inoa Kemika: Glimepiride
CAS: 93479-97-1
ʻO Glimepiride i ka mālama ʻana i ka noninsulin-Dependent Type 2 Diabetes Mellitus
API no ke kūlana kiʻekiʻe, hana kālepa
Inoa Kimia | ʻO Glimepiride |
Nā huaʻōlelo like | Amaryl |
Helu CAS | 93479-97-1 |
Helu CAT | RF-API24 |
Kūlana Kūʻai | Ma ka waihona, hoʻonui ʻia a hiki i nā tona |
ʻĀpana Molekala | C24H34N4O5S |
Kaumaha Molecular | 490.62 |
Lae hehee | 212.2—214.5 ℃ |
Kūlana Hoʻouna | Ma lalo o ka mahana wela |
Brand | Kemika Ruifu |
'ikamu | Nā kikoʻī |
Ka nana aku | Pauda keʻokeʻo a ʻaneʻane keʻokeʻo |
ʻIkepili | IR (e like me ka maʻamau) |
Na mea pili | |
Cis-Isomer (A) | ≤0.80% |
Sulfonamide (B) | ≤0.40% |
Uretana (C) | ≤0.10% |
3-Isomer (D) | ≤0.20% |
ʻO nā mea haumia ʻē aʻe | ≤0.10% |
Huina paumaele | ≤0.50% |
Nalo ma ka maloo | ≤0.50% |
Koena ma ka Ignition | ≤0.10% |
Nā Metala Kaumaha | ≤0.001% |
Hoʻāʻo | 98.0%~102.0% |
Kūlana hoʻāʻo | ʻEulopa Pharmacopeia (EP);ʻAmelika Hui Pū ʻIa Pharmacopoeia (USP) |
Hoʻohana | Mea Hana Lapaʻau Hoʻoikaika (API) |
Pūʻolo: ʻO ka ʻōmole, ʻeke ʻeke alumini, pahu pahu pahu, 25kg / pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;Palekana mai ka malamalama, ka ma'ū a me ka pest infestation.
ʻO Shanghai Ruifu Chemical Co., Ltd. ka mea hana nui a me ka mea hoʻolako o Glimepiride (CAS: 93479-97-1) me ke kiʻekiʻe kiʻekiʻe, ka lāʻau lapaʻau ikaika (API).ʻO Glimepiride kahi lāʻau antidiabetic e kōkua i ka mālama ʻana i ke kō koko.ʻO Glimepiride kahi sulfonylurea hana lōʻihi, ke kolu o ka hanauna me ka hana hypoglycemic.
ʻO Glimepiride (inoa kālepa kumu ʻo Amaryl) kahi lāʻau lapaʻau antidiabetic medium-to-long-acting sulfonylurea antidiabetic.E like me nā sulfonylureas āpau, hana ʻo glimepiride ma ke ʻano he huna huna o ka insulin.Hoʻohaʻahaʻa ia i ke kō koko ma ka hoʻoulu ʻana i ka hoʻokuʻu ʻana o ka insulin mai ka hana ʻana o nā pancreatic beta cell a me ka hoʻonui ʻana i ka naʻau o nā ʻiʻo peripheral i ka insulin.Hoʻopaʻa paha ʻo Glimepiride i ka ATP-sensitive potassium channel receptors ma ka ʻili o ka cell pancreatic, e hōʻemi ana i ka conductance potassium a me ka depolarization o ka membrane.Hoʻoulu ʻia ka depolarization membrane i ka komo ʻana o ka calcium ion ma o nā kahawai calcium-sensitive.ʻO kēia hoʻonui ʻana i ka hoʻonui ʻana o ka calcium ion intracellular e hoʻoulu i ka huna ʻana o ka insulin.Hoʻohana nui ʻia ʻo Glimepiride e mālama i nā poʻe maʻi me ka maʻi diabetes type 2 a hiki ke hōʻemi i ka manawa e ulu ai kekahi i nā hoʻopiʻi o ka maʻi diabetes type 2.Ua ʻae ʻia ka lāʻau lapaʻau e ka FDA ma 1995 a ua hana ʻia e Sanofi-Aventis.Hiki ke hoʻohana pū ʻia me ka papahana ʻai kūpono a me ka hoʻoikaika kino a hiki ke hoʻohana wale ʻia a i ʻole me nā lāʻau antidiabetic ʻē aʻe inā pono.Hiki ke hoʻohana ʻia ʻo Glimepiride ma ke ʻano he monotherapy a i hui pū ʻia me ka insulin.