H-Gly-OMe·HCl CAS 5680-79-5 Glycine Methyl Ester Hydrochloride Assay >99.0%

1. Pono: Pono kēia huahana i ka pauka crystalline keʻokeʻo.
2. Hōʻike:
1) Ka Hoʻoholo ʻana o ka Glycine Methyl Ester Hydrochloride assay
1.1 Hana
Ma lalo o nā kūlana acidic, hoʻopili ka hāpana me kahi nui o ka nitrate kālā, a ua hoʻihoʻi ʻia ka nitrate kālā keu me ka ammonium thiocyanate, e pili ana i ka ammonium ferric sulfate.
Ma ke ʻano he hōʻailona, ​​​​ua hoʻoholo ʻia ka nui o ka chlorine e like me ka nui o ka hopena maʻamau i hoʻopau ʻia, a ua unuhi ʻia ka nui o ka chlorine mai loko mai o ka glycine hydrochloride e loaʻa ai ka ʻike Glycine Methyl Ester Hydrochloride.
1.2 Reagents
Dibutyl phthalate;
ʻO ka waikona Nitric solution: 2 + 3;
ʻO ka hoʻonā titration maʻamau o ke kālā nitrate: c(AgNO3) = 0.1 mol/L
Ammonium thiocyanate solution titration maʻamau: c(NH4SCN) = 0.1 mol/L
Ammonium ferric sulfate (III) wai kuhikuhi: 80 g/L
1.3 Kaʻina Hana Hana
Kauona ma kahi o 0.5g hāpana, pololei i 0.0001g.E hookomo i loko o ka pahu conical 250ml, e hoohehee iloko o ka wai 40ml, e hookomo i 10 ml waikona nitric acid, E hookui (50 ± 0.02) mL kala kala nitrate titration solution, 3mL ammonium ferric sulfate indicator solution, 4mL dibutyl phthalate, and thiocyanate Ammonium solution titration. titrated a hiki i ka ʻeleʻele ʻeleʻele ka hopena a waiho ʻole ke kala no 30 s.
1.4 Helu hopena
ʻO ka hapa nui o ka glycine methyl ester hydrochloric acid content w1, i hōʻike ʻia ma ke ʻano he %, ua helu ʻia e like me ka Equation (1):
w1= (c1V1-c2V2)*M/1000/m * 100-w2 *1.126 formula (1)
Ma hea:
V1: Ka nui o ka solution titration maʻamau o ke kālā nitrate (ml)
V2: Ka nui o ka hoʻoheheʻe titration maʻamau o ka ammonium thiocyanate i hoʻopau ʻia e ka titration (ml)
c1: Waiwai pololei o ka solution titration maʻamau o ke kālā nitrate (mol/L)
c2: Waiwai pololei o ka solution titration maʻamau o ka ammonium thiocyanate (mol/L)
w2: ʻO ka hakina nui (%) o ka glycine hydrochloride maʻiʻo e like me ka mea i hoʻoholo ʻia ma ka Pauku 4.2
M: Ka nui mola o ka glycine methyl ester hydrochloride (g/mol)
1.126: Ka helu hoʻololi o glycine hydrochloride i Glycine methyl ester hydrochloride.
Ua lawe ʻia ka helu helu mean o nā hopena ana ʻelua ma ke ʻano he hopena ana, a ʻo ka ʻokoʻa loa ma waena o nā hopena ana ʻelua ʻaʻole ʻoi aku ma mua o 0.05%.
2) Ka hoʻoholo ʻana o ka glycine hydrochloride maʻiʻo
2.1 Hana
Me ka hoʻohana ʻana i ka dimethyl yellow ma ke ʻano he hōʻailona, ​​​​ua hoʻopaʻa ʻia ka hāpana me ka sodium hydroxide standard titrating solution, a ua hoʻonui ʻia ka nui o ka hopena e like me ka hoʻohana ʻana i ka maʻamau sodium hydroxide.
E helu i ka glycine hydrochloride maʻiʻo.
2.2 Reagent
ʻO ka hopena titration maʻamau o ka sodium hydroxide: c (NaOH) = 0.1mol/L
ʻO ka wai hōʻailona melemele Dimethyl: 10 g/L
2.3 Kaʻina Hana Hana
E kaupaona ma kahi o 5.0 g laʻana keʻena hana, pololei i ka 0.0001g, i loko o ka bea 200 ml, e hoʻoheheʻe me 50ml wai, a hoʻohui i 5 kulu o dimethyl.
ʻO ka wai hōʻailona melemele, me ka sodium hydroxide maʻamau titration solution titration a hiki i ka hopena mai ka ʻulaʻula a ʻalani melemele ka hopena.
2.4 Helu Hua
Hōʻike ʻia ka hakina w2 o ka glycine hydrochloride ma ke ʻano he % a helu ʻia e like me ka Equation (2):
w2 =(V/1000)cM/m *100 formula (2)
Ma hea:
V: Ka nui o ka waiʻona titration maʻamau o ka sodium hydroxide (mL)
c: Waiwai pololei o ka sodium hydroxide maʻamau titration solution concentration (mol/L)
M: Ka nui o ka mola o ka glycine hydrochloride (g/mol)
m: Waiwai nui o ka hāpana (g)
Ua lawe ʻia ka helu helu mean o nā hopena ana ʻelua ma ke ʻano he hopena ana, a ʻo ka ʻokoʻa loa ma waena o nā hopena ana ʻelua ʻaʻole ʻoi aku ma mua o 0.05%
3. Ka helu heheʻe: E like me ke ʻano o ka hoʻoholo ʻana i ka helu heheʻe (Chinese Pharmacopoeia 2010 Appendix VIC), ʻo 172-178 ºC ka pae hoʻoheheʻe.
4. Hoʻomaloʻo i ke kaumaha kaumaha: lawe i kēia huahana ma 105.0 ℃ a maloʻo i ke kaumaha mau.ʻAʻole ʻoi aku ka nui o ke kaumaha ma mua o 0.5%.
5. Waihona: Pono e hoʻopili ʻia kēia huahana mai ka mālamalama.