HATU CAS 148893-10-1 Peptide Coupling Reagent Maʻemaʻe >99.5% (HPLC) Hale Hana

ʻO HATU (CAS: 148893-10-1) he peptide coupling reagent a hoʻohana ʻia i ka peptide synthesis.Hoʻohana ʻia ʻo HATU i ka hopena o ka hui carboxyl a me ka hui amino e synthesize i ka paʻa peptide.Hoʻopili maikaʻi ʻia ʻo HATU e wikiwiki i ke kaʻina hana hoʻohui a hōʻemi i ka nalowale o ka pono chiral.
Mea hoʻopili peptide;e hoʻohana i ke ʻano hana synthesis solid-phase e hoʻomākaukau ai i nā peptides pili i ka N-arylsulfonamide;ʻO ka noiʻi hou loa e hōʻike ana ʻo ke aniani a me ka hoʻonā ʻana o ka mea hoʻohui i ka paʻakai guanidine N-oxide, ʻaʻole ka urea cationic compound;mea hoʻohui maikaʻi i ka peptide synthesis solid-phase.
Aia ka HATU i ka hui guanidinium o nā reagents hoʻohui (HBTU, TBTU, HCTU, TCTU).ʻOi aku ka maikaʻi o ka hoʻohui ʻana i ka reagent, e hōʻike ana i ka epimerization liʻiliʻi i ka wā o ka hoʻopili ʻana i nā protocol SPPS/Fmoc.ʻO kahi "maʻamau gula" ma SPPS peptide chemistry, paʻakikī paʻakikī, a me ka condensation ʻāpana.
ʻO ka HATU he mea hoʻohui hoʻohui ikaika e hoʻopuka pinepine i nā hopena maikaʻi i nā hui paʻakikī e hoʻohālikelike ʻia me HBTU.ʻOi aku ka wikiwiki o ka hoʻohui ʻana me ka HATU, e hoʻohua i nā hua kiʻekiʻe a me ka liʻiliʻi o ka racemization.
Reagent no: Synthesis of Aurora A kinase inhibitors;Nā hopena hoʻokumu paʻa Amide.Catalyst no: Selective acylation;Selecocyclization-oxidation deelenation sequence;Ka hoʻomākaukau ʻana i nā peptides pili i ka N-arylsulfonamide e ka synthesis solid-phase.