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N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS 152460-10-1 Imatinib Mesylate Intermediate High Clean Clean
  • N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS 152460-10-1 Imatinib Mesylate Intermediate Maʻemaʻe Kiʻekiʻe

N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS 152460-10-1 Imatinib Mesylate Intermediate Maʻemaʻe Kiʻekiʻe

ʻO ka wehewehe pōkole:

Inoa: N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea

Synonyms: Imatinib Mesylate Intermediate

CAS: 152460-10-1

ʻAno: ʻĀlani ʻAlani a i ka pauda melemele a i ke aniani

Maʻemaʻe: ≥98.0% (HPLC)

ʻO Intermediate o Imatinib Mesylate (CAS: 220127-57-1) i ka mālama ʻana iā Philadelphia Chromosome-Positive Chronic Myeloid Leukemia (Ph+CML)

Inquiry: alvin@ruifuchem.com


Huahana Huahana

Nā Huahana Pili

Huahana Huahana

wehewehe:

Hoʻolako Kalepa ʻo Imatinib Mesylate a me nā mea e pili ana i waena:
Imatinib Mesylate CAS: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS: 152460-10-1
4-[(4-Methylpiperazin-1-yl)methyl]ʻakika benzoic dihydrochloride CAS: 106261-49-8

Na Waiwai Kemika:

Inoa Kimia N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea
Nā huaʻōlelo like Imatinib Mesylate Intermediate;2-(5-Amino-2-methylanilino)-4-(3-pyridyl)pyrimidine
Helu CAS 152460-10-1
Helu CAT RF-PI230
Kūlana Kūʻai Ma ka waihona, ʻoi aku ka nui o ka hana a hiki i nā tona
ʻĀpana Molekala C16H15N5
Kaumaha Molecular 277.32
Lae hehee 133.0-135.0 ℃
Brand ʻO Ruifu Chemical

Nā kikoʻī:

'ikamu Nā kikoʻī
Ka nana aku ʻO ka ʻAlani māmā a i ka pauda melemele i ke aniani
Maʻemaʻe / Kaʻina Hanana ≥98.0%
Nalo ma ka maloo ≤0.50%
Ke koena ma ka ʻā ≤0.50%
Huina paumaele ≤2.0%
ʻO ka haumia hoʻokahi kiʻekiʻe ≤1.0%
Metala Kaumaha ≤20ppm
Kūlana hoʻāʻo ʻOihana Kūlana
Hoʻohana Ka waena o Imatinib Mesylate (CAS: 220127-57-1)

Pūʻolo a me ka waiho ʻana:

Pūʻolo: ʻO ka ʻōmole, ʻeke ʻeke alumini, pahu pahu pahu, 25kg / pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.

Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;Palekana mai ka malamalama, ka ma'ū a me ka pest infestation.

Pono:

1

FAQ:

Noi:

ʻO Shanghai Ruifu Chemical Co., Ltd. ka mea hana nui a me ka mea hoʻolako o N-(5-Amino-2-methylphenyl) -4-(3-pyridyl) -2-pyrimidinea (CAS: 152460-10-1) me ke kūlana kiʻekiʻe .
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea (CAS: 152460-10-1) he mea waena maʻamau i ka synthesis o Imatinib Mesylate (CAS: 220127-57-1). ) API.
ʻO ka Imatinib mesylate kahi mole liʻiliʻi e kāohi ana i ka c-Abl protein-tyrosine kinase, kahi kinase koʻikoʻi no ka hoʻonui ʻana o ka maʻi leukemia myelogenous maʻi (CML).ʻO kahi hanana translocation ma waena o nā chromosomes 9 a me 22 e hoʻopuka i ka chromosome Philadelphia, a laila e hoʻopuka i ka protein hui Bcr-Abl me ka hana kinase aberrant e hoʻoikaika i ka hoʻonui wikiwiki ʻana o ke kelepona.Hoʻopili ʻo Imatinib mesylate i kēia kinase koʻikoʻi, hoʻopau i ka ulu pili CML.Ua hōʻike hou ʻia ʻo Imatinib mesylate e kāohi i ka PDGFR a me nā tyrosine kinases e pili ana me c-Kit.Ua hoʻohana ʻia nā ʻano hana i loaʻa i ka Imatinib mesylate i ka mālama ʻana i nā maʻi maʻi like ʻole.
ʻO ka Imatinib mesylate he mea hoʻopaneʻe tyrosine kinase.Kūkākūkā loa no ka BCR-ABL, ka enzyme pili i ka maʻi maʻi myelogenous maʻi (CML) a me kekahi mau ʻano o ka maʻi maʻi lymphoblastic acute (ALL).He mea hoʻopaʻapaʻa ikaika a koho i ka v-Abl tyrosine kinase inhibitor (IC50 = 38 nM).Kāohi pū i ka PDGFR a me ka c-kit.Hōʻike i ka koho no v-Abl ma luna o kahi papa o nā tyrosine a me nā kinases protein serine/threonine.Kāohi koho i ka ulu ʻana o ka PDGF-hoʻoulu ʻia o ka v-abl-transformed PB-3 cell a me ka v-sis-transformed BALB/c 3T3 cell in vitro.Hōʻike i nā hopena antitumor i nā ʻiole e lawe ana i nā cell AMuLV a i ʻole BBL/c 3T3 v-sis.Kāohi i ka hana hou ʻana o SARS-CoV a me MERS-CoV in vitro (ʻo EC50 nā waiwai he 9.823 a me 17.689 μM, kēlā me kēia).

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