Imatinib Mesylate CAS 220127-57-1 Assay 98.0%~102.0% Ph+CML API Hale Hana Kiʻekiʻe
Hoʻolako Kalepa ʻo Imatinib Mesylate a me nā mea e pili ana i waena:
Imatinib Mesylate CAS: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS: 152460-10-1
4-[(4-Methylpiperazin-1-yl)methyl]ʻakika benzoic dihydrochloride CAS: 106261-49-8
| Inoa Kimia | Imatinib Mesylate (ʻano alpha) |
| Nā huaʻōlelo like | Imatinib Methanesulfonate;STI571 Mesylate;CGP-57148B |
| Helu CAS | 220127-57-1 |
| Helu CAT | RF-API19 |
| Kūlana Kūʻai | Ma ka waihona, hoʻonui ʻia a hiki i nā tona |
| ʻĀpana Molekala | C30H35N7O4S |
| Kaumaha Molecular | 589.71 |
| Kūlana Hoʻouna | Ma lalo o ka mahana wela |
| Brand | Kemika Ruifu |
| 'ikamu | Nā kikoʻī |
| Ka nana aku | Keʻokeʻo a i ka pauka kristal keʻokeʻo |
| Ka hikiwawe | Maʻalahi e hoʻoheheʻe i ka wai |
| ʻIkepili HPLC | Kūlike ka manawa paʻa kiʻekiʻe o ka spectrum me kēlā |
| IR Identification | Kūlike ke kiko o ka hāpana infrared me ka hāpana kuhikuhi |
| Lae hehee | 214.0~222.0 ℃ |
| Nalo ma ka maloo | ≤0.50% |
| Koena ma ka Ignition | ≤0.10% |
| Nā Metala Kaumaha | ≤20ppm |
| Na mea pili | (1) haumia G: NMT 0.3% |
| (2) haumia B: NMT 0.3% | |
| (3) haumia C: NMT 0.3% | |
| (4) haumia D: NMT 0.3% | |
| (5) haumia A: NMT 0.3% | |
| (6) haumia H: NMT 0.3% | |
| (7) haumia F: NMT 0.3% | |
| (8) haumia E: NMT 0.3% | |
| (9) ʻO ka haumia nui loa: NMT0.1% | |
| Nā mea hoʻoheheʻe koena | (1) Ethyl Acetate: NMT 5000ppm |
| (2) Methanol: NMT3000ppm | |
| (3) Dichloromethane: NMT 600ppm | |
| (4) Ethanol: NMT 5000ppm | |
| (5) Toluene: NMT 890ppm | |
| (6) Dimethyl Sulfoxide: NMT5000ppm | |
| ʻIke HPLC | 98.0%~102.0% (C30H35N7SO4 i helu ʻia ma ke kumu Anhydrous) |
| Kūlana hoʻāʻo | Kūlana ʻoihana |
| Hoʻohana | API;Ph+CML |
Pūʻolo: ʻO ka ʻōmole, ʻeke ʻeke alumini, pahu pahu pahu, 25kg / pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;Palekana mai ka malamalama, ka ma'ū a me ka pest infestation.
ʻO Imatinib Mesylate (CAS 220127-57-1) kahi mole liʻiliʻi e kāohi ana i ka c-Abl protein-tyrosine kinase, kahi kinase koʻikoʻi no ka hoʻonui ʻana o ka maʻi leukemia myelogenous maʻi (CML).Kūkākūkā loa no ka BCR-ABL, ka enzyme pili i ka maʻi maʻi myelogenous maʻi (CML) a me kekahi mau ʻano o ka maʻi maʻi lymphoblastic acute (ALL).He mea hoʻopaʻapaʻa ikaika a koho i ka v-Abl tyrosine kinase inhibitor (IC50 = 38 nM).ʻO kahi hanana translocation ma waena o nā chromosomes 9 a me 22 e hoʻopuka i ka chromosome Philadelphia, a laila e hoʻopuka i ka protein hui Bcr-Abl me ka hana kinase aberrant e hoʻoikaika i ka hoʻonui wikiwiki ʻana o ke kelepona.Hoʻopili ʻo Imatinib mesylate i kēia kinase koʻikoʻi, e kāpae ana i ka ulu pili CML.Ua hōʻike hou ʻia ʻo Imatinib mesylate e kāohi i ka PDGFR a me nā tyrosine kinases e pili ana me c-Kit.
![4-[(4-Methylpiperazin-1-yl)methyl]ʻakika benzoic dihydrochloride CAS 106261-49-8 Imatinib Mesylate Waena Maʻemaʻe Kiʻekiʻe](https://www.ruifuchemical.com/uploads/d1fa2a19-300x300.jpg)