Irinotecan Hydrochloride CAS 100286-90-6 Maʻemaʻe ≥99.0% (HPLC) API USP Maʻamau Maʻemaʻe Kiʻekiʻe
Mea Hana Hana Irinotecan a me nā mea pili i waena:
Irinotecan Hydrochloride CAS: 100286-90-6
Irinotecan Free Base CAS: 97682-44-5
Irinotecan Hydrochloride Trihydrate CAS: 136572-09-3
7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3
1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4
| Inoa Kimia | Irinotecan Hydrochloride |
| Nā huaʻōlelo like | Camptothecin II;CPT-II |
| Helu CAS | 100286-90-6 |
| Helu CAT | RF-API50 |
| Kūlana Kūʻai | Ma ka waihona, hoʻonui ʻia a hiki i nā tona |
| ʻĀpana Molekala | C33H39ClN4O6 |
| Kaumaha Molecular | 623.15 |
| Lae hehee | 250-256 ℃ (Dek.) |
| Nā Kūlana Waihona | Ma lalo o ka mahana wela |
| Brand | Kemika Ruifu |
| 'ikamu | Nā kikoʻī |
| Ka nana aku | Pada keʻokeʻo a i ʻole keʻokeʻo |
| Ka hikiwawe | Hiki ke hoʻoheheʻe ʻia i ka wai a me ka methanol, hiki ke hoʻoheheʻe ʻia i ka chloroform, ethanol |
| ʻIkepili IR | Pono ke kiko o ka infrared absorption spectrum o ka la'ana ho'ā'o me ko ka ma'amau kuhikuhi |
| ʻIke HPLC | Pono ka manawa paʻa o ka piko nui o ka hāpana hāpana e like me ko ka maʻamau kuhikuhi. |
| ʻIkepili | Hoʻokō i nā koi o nā hoʻokolohua no ka pane ʻana o Chloride Positive |
| Māmā (KF) | 7.0%~9.0% w/w |
| Koena ma ka Ignition | ≤0.10% |
| Nā Metala Kaumaha | ≤20ppm |
| ʻO Irinotecan Hydrochloride Enantiomer | ≤0.10% (HPLC) |
| 7-Desetyl Irinotecan | ≤0.15% |
| ʻO Irinotecan pili pūhui A | ≤0.15% |
| 11-Ethyl Irinotecan | ≤0.15% |
| Camptothecin | ≤0.15% |
| Irinotecan Pūhui Pili B | ≤0.15% |
| 7-Ethylcanptothecin | ≤0.15% |
| 7,11-Diethyl-10-Hydroxy Camptothecin | ≤0.15% |
| ʻO nā mea haumia ʻole i hōʻike ʻia | ≤0.10% |
| Huina paumaele | ≤0.50% |
| Nā mea hoʻoheheʻe koena (GC) | |
| Methanol | ≤2000ppm |
| Acetone | ≤2000ppm |
| Dichloromethane | ≤500ppm |
| Peteoleum Etera: | ≤100ppm |
| Ethyl Acetate | ≤2000ppm |
| Benzene | ≤2ppm |
| Nā Endotoxins Bacterial | ≤0.29 EU/mg Irinotecan |
| Palena Microbial | Ka helu ʻana i nā ʻano microbial Aerobic: <1000 cfu/g |
| Molds a me ka hu | <100 cfu/g |
| Maʻemaʻe / Kaʻina Hanana | ≥99.0% (HPLC, ma ke kumu anhydrous) |
| Kūlana hoʻāʻo | ʻAmelika Hui Pū ʻIa Pharmacopeia (USP). |
| Hoʻohana | Mea Hana Lapaʻau Hoʻoikaika (API) |
Pūʻolo: ʻO ka ʻōmole, ʻeke ʻeke alumini, pahu pahu pahu, 25kg / pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;Palekana mai ka malamalama, ka ma'ū a me ka pest infestation.
ʻO lrinotecan hydrochloride (CAS 100286-90-6), he semi-synthetic, wai hoʻoheheʻe ʻia o ka potent anticancer agent camptothecin, i hoʻokuʻu ʻia ma Iapana no ka mālama ʻana i nā maʻi maʻi ʻāʻī, ovarian, a me ka cervical cancer.Hoʻohana ʻo lrinotecan i kāna hana antitumor ma o ke kāohi ʻana i ka topoisomerase I, he enzyme cellular e pili ana i ka mālama ʻana i ke ʻano topographic o DNA i ke kaʻina o ka unuhi ʻana, transcription, a me ka mitosis.Hoʻopau ʻo lrinotecan i ka de-esterification in vivo e hāʻawi i kahi metabolite ikaika, SN-38, ʻoi aku ka ikaika o 1000 ma mua o ka makua.ʻO ka hui pū ʻana o ka irinotecan me kekahi lāʻau anticancer i hoʻohana nui ʻia, ʻo cisplatin, ua hōʻike ʻia ʻoi aku ka maikaʻi ma mua o kēlā me kēia mea hoʻokahi wale nō.Aia ʻo lrinotecan i nā hoʻokolohua lapaʻau no ka ʻōpū, ka umauma, ka ʻili, ka colorectal, pancreatic cancers, mesothelioma a me ka lymphoma non-Hodgkin.
