Irinotecan Hydrochloride Trihydrate CAS 136572-09-3 Hale Hana API Maʻemaʻe Kiʻekiʻe
Mea Hana Hana Irinotecan a me nā mea pili i waena:
Irinotecan Hydrochloride CAS: 100286-90-6
Irinotecan Free Base CAS: 97682-44-5
Irinotecan Hydrochloride Trihydrate CAS: 136572-09-3
7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3
1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4
| Inoa Kimia | Irinotecan Hydrochloride Trihydrate |
| Nā huaʻōlelo like | Irinotecan HCl Trihydrate;CPT-11 Trihydrate;Irinotecan HCL 3H2O |
| Helu CAS | 136572-09-3 |
| Helu CAT | RF-API52 |
| Kūlana Kūʻai | Ma ka waihona, hoʻonui ʻia a hiki i nā tona |
| ʻĀpana Molekala | C33H38N4O6·HCl·3H2O |
| Kaumaha Molecular | 677.20 |
| Lae hehee | 250.0~256.0℃ (Dek.) |
| Brand | Kemika Ruifu |
| 'ikamu | Nā kikoʻī |
| Ka nana aku | Melemele Māmā a i ʻole Melemele Crystalline Powder |
| Hōʻike (w/w) | 98.0%~102.0% |
| Maʻemaʻe (HPLC) | ≥99.5% |
| Ka hikiwawe | Hiki ke hoʻoheheʻe ʻia i ka wai, ethanol a i ʻole chloroform, ʻAʻole hiki ke hoʻoheheʻe ʻia i ka acetone |
| ʻIkepili | na IR a me HPLC, Kulike |
| Hoʻololi Optical kikoʻī | +60°~+73° |
| Wai | 7.0%~9.0% |
| Ke koena o na mea hoohehee | Hoʻokō me nā Koina ICH |
| Koena ma ka Ignition | ≤0.20% |
| Klorida | 5.0%~6.0% |
| Waiwai pH | 3.0~5.0 |
| Nā Metala Kaumaha | ≤20ppm |
| Nā haumia pākahi | ≤0.10% |
| Huina paumaele | ≤0.50% |
| Kūlana Waihona | E kūʻai ma 2-8 ° C, i loko o nā pahu i hoʻopaʻa ʻia a pale i ka mālamalama a me ka maʻa |
| Kūlana hoʻāʻo | Kūlana ʻoihana |
| Hoʻohana | Mea Hana Lapaʻau Hoʻoikaika (API) |
Pūʻolo: ʻO ka ʻōmole, ʻeke ʻeke alumini, pahu pahu pahu, 25kg / pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;Palekana mai ka malamalama, ka ma'ū a me ka pest infestation.
ʻO Shanghai Ruifu Chemical Co., Ltd. ka mea hana nui a me ka mea hoʻolako o Irinotecan Hydrochloride Trihydrate (CAS: 136572-09-3) me ke ʻano kiʻekiʻe.
ʻO ka Irinotecan Hydrochloride Trihydrate he mea hoʻopaneʻe topoisomerase I i hoʻohana nui ʻia no ka mālama ʻana i ka maʻi kanesa colon a me ka maʻi ʻaʻai rectal, e pale ana i ka religation o ke kaula DNA ma o ka hoʻopaʻa ʻana i ka paʻakikī topoisomerase I-DNA.ʻO lrinotecan hydrochloride, he semi-synthetic, wai hoʻoheheʻe ʻia o ka camptothecin agent anticancer potent, i hoʻokuʻu ʻia ma Iapana no ka mālama ʻana i nā maʻi maʻi ʻāʻī, ovarian, a me ka cervical cancer.Hoʻohana ʻo lrinotecan i kāna hana antitumor ma o ke kāohi ʻana i ka topoisomerase I, he enzyme cellular e pili ana i ka mālama ʻana i ke ʻano topographic o DNA i ke kaʻina o ka unuhi ʻana, transcription, a me ka mitosis.Hoʻopau ʻo lrinotecan i ka de-esterification in vivo e hāʻawi i kahi metabolite ikaika, SN-38, ʻoi aku ka ikaika o 1000 ma mua o ka makua.ʻOiai ʻoi aku ka liʻiliʻi o ka ʻawaʻawa ma mua o ka camptothecin, he helu nui o nā maʻi i nā hoʻokolohua lapaʻau i hōʻike i nā hopena ʻaoʻao o ka leukopenia, ka maʻi paʻi, nauseahromiting, a me ka alopecia.ʻO ka hui pū ʻana o ka irinotecan me kekahi lāʻau anticancer i hoʻohana nui ʻia, ʻo cisplatin, ua hōʻike ʻia ʻoi aku ka maikaʻi ma mua o kēlā me kēia mea hoʻokahi wale nō.Aia ʻo lrinotecan i nā hoʻokolohua lapaʻau no ka ʻōpū, ka umauma, ka ʻili, ka colorectal, pancreatic cancers, mesothelioma a me ka lymphoma non-Hodgkin.
