Ketorolac CAS 74103-06-3 Maʻemaʻe >98.5% (HPLC)

ʻO Ketorolac (CAS: 74103-06-3) he lāʻau analgesic non-steroid a me ka lāʻau anti-inflammatory, he derivative o pyrrolidone. ʻO ka hana kemika a me ka hana pharmacological e like me Tolectin, Zoaesthetic acid a me Indometacin.Ma ke kāohi ʻana i ka cyclooxygenase, ke kāohi nei ia i ka synthesis a me ka hoʻokuʻu ʻana o nā prostaglandins, a hana i nā hopena anti-inflammatory.Hiki iā ia ke ho'ēmi i ka mahana i hoʻouluʻia e ke kumu wela, e pili ana i ka paleʻana i ka synthesis o prostaglandin i loko o ke kikowaena o ke kino. hoʻohui.I nā hoʻokolohua holoholona, ​​ʻoi aku ka ikaika o ka hopena analgesic ma mua o ka aspirin, indomethacin a me naproxen. Ua like a ʻoi aku ka maikaʻi ma mua o ka hopena anti-inflammatory o naproxen a me indomethacin, phenylbutazone, ʻOi aku ka ikaika o kona hopena antipyretic ma nā ʻiole ma mua o ka aspirin a me phenylbutazone a like me ʻO ka indomethacin a me ka naproxen. Hoʻopaʻa ia i ka hoʻohui platelet i hoʻokomo ʻia e ka arachidonic acid a me ka collagen.Akā ʻaʻole ia e kāohi i ka induction o adenosine diphosphate (ADP).ʻO kēia huahana e wikiwiki a hoʻopau loaʻia ma hope o ka hoʻokomoʻana i ka intramuscular, a ua aneane hiki ke hoʻopauʻia ma hope o ka hoʻoponopono waha. Hiki i kaʻai ke ho'ēmi i ka wikiwiki o ka absorption, akā,ʻaʻole ia e pili i ke kiʻekiʻe o ka absorption, aʻo ka bioavailability he 80% ~ 100%.10 mau minuke ma hope o ka hoʻokele intramuscular o 30mg, hoʻomaha pinepine ia i ka ʻeha.Ma hope o 50 mau minuke, piʻi ka kiʻekiʻe o ka plasma i ka 2.2 g / mL.Ma hope o 30-60 mau minuke o ka hoʻoponopono waha, ua hoʻomaha ʻia ka ʻeha a ʻoi aku ka kiʻekiʻe o ka plasma ma 1.5 a 4 mau hola.ʻO ka hapalua o ke ola o ka plasma o ka poʻe ʻōpio ma kahi o 5.3 mau hola, a no ka poʻe ʻelemakule ma kahi o 7 mau hola, a hiki ke mālama ʻia ka hopena analgesic no 6-8 mau hola.E hoʻokuʻu ʻia ʻo 91.4% mai ka urinary tract, ʻo ke koena e hoʻokuʻu ʻia mai ka excrement. I nā mea maʻi me ka lawa ʻole o ka renal, ua emi ka nui o ka hoʻomaʻemaʻe plasma a hoʻolōʻihi i ka hapalua o ke ola, no laila e hoʻemi ʻia ka dosage.

Hoʻohana lapaʻau: Hoʻohana nui ʻia ʻo Ketorolac no ka mālama ʻana i ka ʻeha pōkole e like me ka ʻeha postoperative (e like me ka ʻōpū, ka umauma, Urology, gynecology, Department of Stomatology, orthopedic surgery a me ka ʻeha) a me ka ʻeha o ka ʻiʻo skeletal ma muli o nā kumu like ʻole, e like me ka sprain, dislocation, fracture and soft tissue injury, a me na eha eha i hanaia e na ma'i e ae, e like me ka eha postpartum, acute renal colic, toothache, sciatica, late cancer pain, wound pain, biliary colic, etc.. Hiki ke hoohana ia. i mea pani no ka morphine a me ka pethidine.