L-Alaninamide Hydrochloride CAS 33208-99-0 (H-Ala-NH2·HCl) Hōʻike 98.0~102.0% Safinamide Intermediate Factory

Hoʻohana ʻia ʻo L-Alaninamide Hydrochloride (H-Ala-NH2·HCl) (CAS: 33208-99-0) ma ke ʻano he lāʻau lapaʻau.Hoʻohana ʻia ʻo L-Alaninamide Hydrochloride no ka hoʻomākaukau ʻana i nā derivatives amide hou o nā pūhui steroidal [3,2-c] pyrazole me ka hana glucocorticoid.ʻO L-Alaninamide Hydrochloride kahi mea waena o Safinamide (CAS: 133865-89-1) a me Safinamide Mesylate (CAS: 202825-46-5).ʻO ka Safinamide he mea hoʻopaneʻe koho a hiki ke hoʻohuli ʻia o ka monoamine oxidase B (MAO-B, IC50=98 nM me ka nui o 100-fold selectivity ma luna o MAO-A. Hōʻike i ka hana anticonvulsant a pale aku i ka kainate-induced seizures a me ka neurodegeneration hippocampal i nā ʻano ʻiole. ka hōʻailona glutamatergic overactive ma o ka hoʻohana ʻana i ka sodium channel blockade. He lāʻau lapaʻau hou no ka maʻi o Parkinson me nā ʻano hana he nui. He mea hoʻohui i ka dopamine agonist therapy i ka wā mua o Parkinson. Ua ʻae ʻia ʻo Safinamide methanesulfonate i Pepeluali 2015 e ka EMA no ka mālama ʻana ʻO ka maʻi o Parkinson ka waena a hiki i ka hope. Ua komo kēia ʻae i ka hoʻohana ʻana i ka lāʻau lapaʻau ma ke ʻano he lāʻau hoʻohui no ka hoʻohana ʻana me Levodopa, ʻo ia wale nō a i hui pū ʻia me nā lāʻau lapaʻau ʻē aʻe no ka maʻi o Parkinson. Safinamide methanesulfonate, he α-aminoamide waha i ʻike mua ʻia e Farmitalia Carlo Erba a ma hope i hoʻomohala ʻia e Newron/Zambon, hana ma ke ʻano he mea koho nui a hoʻohuli ʻia o MAO-B, e alakaʻi ana i ka piʻi ʻana o ka dopamine a me ka hoʻomaikaʻi hou ʻana i nā hōʻailona kaʻa o ka maʻi o Parkinson, nā hopena ʻaoʻao e hopena pinepine mai. ka hoʻohana ʻana i nā lāʻau lapaʻau kuʻuna ʻē aʻe e hilinaʻi ana i ka dopamine replacement therapy.