Levodopa (L-DOPA) CAS 59-92-7 99.0~100.5% USP BP EP Ka ma'i Anati-Parkinson ma'amau.
ʻO Shanghai Ruifu Chemical Co., Ltd. ka mea hana nui a me ka mea hoʻolako o Levodopa (L-DOPA) (CAS: 59-92-7) me ke kūlana kiʻekiʻe, Anti-Parkinson's Disease.ʻOiai ʻo ia kekahi o nā mea hoʻolako Levodopa nui loa ma Kina, hāʻawi ʻo Ruifu Chemical iā Levodopa kūpono a hiki i nā kūlana honua, e like me AJI, USP, EP, BP a me IP.Ka mana hana 300 tons i kēlā me kēia makahiki.Hiki iā mākou ke hāʻawi i ka COA, ka lawe ʻana i ka honua holoʻokoʻa, nā mea liʻiliʻi a me ka nui i loaʻa.Inā makemake ʻoe iā Levodopa,Please contact: alvin@ruifuchem.com
Inoa Kimia | Levodopa |
Nā huaʻōlelo like | L-DOPA;3-(3,4-Dihydroxyphenyl)-L-Alanine;L-3-(3,4-Dihydroxyphenyl)alanine;3,4-L-Dihydroxyphenylalanine;3-Hydroxy-L-Tyrosine;L-3-Hydroxytyrosine;H-Tyr(3-OH)-OH |
Helu CAS | 59-92-7 |
Helu CAT | RF-API55 |
Kūlana Kūʻai | I loko o ka waihona, hana hiki ke 300 tona no ka makahiki |
ʻĀpana Molekala | C9H11NO4 |
Kaumaha Molecular | 197.19 |
Lae hehee | 276.0~278.0℃(māmā) |
Pilikino | Māmā Māmā, ʻEa Ea |
Solubility i ka wai | Hiki i ka wai |
Ka hikiwawe | ʻAʻole hiki ke hoʻonā i loko o Chloroform, Ethanol, Benzene, Etera. |
Solubility i ka 1mol/L HCl | Hoʻoheheʻe ʻia i loko o ka Dilute Hydrochloric Acid.ʻAneʻane Mākaʻikaʻi |
Paʻa | Paʻa.Kūlike ʻole me nā ʻĀpana Oxidizing ikaika.Mālamalama a me ka ea |
Brand | Kemika Ruifu |
'ikamu | Nā kikoʻī |
Ka nana aku | Keʻokeʻo a i ʻole ka waiu keʻokeʻo Crystalline pauda |
ʻIkepili | Infrared Absorption Spectrum |
ʻO ka ʻōniʻoniʻo [α]20/D | -1.27° a i -1.34° |
ʻIke ʻia o ka Haʻina | Holo i ka ho'āʻo |
Ka nui o ka ʻāpana | 100% hele ma 80 |
Na mea pili | |
L-Tyrosina | ≤0.10% |
Huina Levodopareted | ≤0.10% |
3-Methoxytyrosine | ≤0.50% |
Huina paumaele | ≤1.00% |
ʻIke ʻole i nā mea haumia | ≤0.10% |
UV Spectrum MaxE1%1cm | 137~147 (280nm) |
Nā Metala Kaumaha (e like me Pb) | ≤10ppm |
Nalo ma ka maloo | ≤1.00% (ma 105 ℃ no 4 mau hola) |
ʻO ke koena ma ka ʻāʻī (Sulfated) | ≤0.10% |
Hoʻāʻo | 99.0%~100.5% |
PH | 4.5~7.0 (0.10g i 10ml o H2O lulu no 15 mau minuke) |
Kūlana hoʻāʻo | AJI/USP/BP/EP/IP/JP Kūlana |
Hoʻohana | Mea Hana Lapaʻau Hoʻoikaika (API);ʻO ka maʻi anti-Parkinson |
ʻO ka hoʻololi ʻana [EP]
E hoʻoheheʻe i ka nui like me 0.200g o ka mea maloʻo a me 5g o hexamethylenetetramine R i loko o 10ml o 1mol/L hydrochloric acid a hoʻoheheʻe i 25.oml me ka waikawa like.E ʻae i ka hoʻonā e kū i pale ʻia mai ka mālamalama no 3h.ʻO ke kihi o ka huli ʻana o ka optical he -1.27° a i -1.34°
ʻIke ʻia o ka Haʻina
Disslove 1.0g i ka 1mol/L hydrochloric acid a dilute i 25ml me ka solvnet like.ʻAʻole ʻoi aku ka ikaika o ka waihoʻoluʻu ma mua o ka hoʻonā kuhikuhi BY6.
Nā mea pili [EP]
E noʻonoʻo me ka chromatography ʻāpana lahilahi, me ka hoʻohana ʻana i ka cellulose no ka chromatography R ma ke ʻano he mea uhi.
ʻO ka hopena hoʻāʻo-E hoʻoheheʻe i 0.1g o ka mea e nānā ʻia i loko o 5ml o ka anhydrous formic acid R a hoʻoheheʻe i 10ml me ka methanol R. E hoʻomākaukau koke ma mua o ka hoʻohana ʻana.
Haʻina kuhikuhi (a)-E hoʻoheheʻe i 0.5ml o ka hopena hoʻāʻo i 100ml me ka methanol R.
Pane kuhikuhi (b)-E hoʻoheheʻe i 30mg o tyrosine R i 1ml o ka waika formic anhydrous R a hoʻoheheʻe ʻia i 100ml me ka methanol R. E hoʻohui i 1ml o kēia wai me 1ml o ka hopena hoʻāʻo.
E hoʻopili paʻa i ka pā e like me nā kaula 20mm ka lōʻihi, 1oμl o ka hoʻonā hoʻāʻo, 10μl o ka hopena kuhikuhi (a) a me 20μl o ka hopena kuhikuhi (b).Maloo i ke au o ka ea.E hoʻomohala ma luna o kahi ala o 15cm me ka hoʻohana ʻana i ka hui ʻana o 50 mau puke o ka butanol R, 25 mau puke o ka ʻakika acetic glacial R a me 25 mau puke wai.E hoʻomaloʻo i ka pā i loko o ke ea mehana a kāpīpī me kahi hui hou i hoʻomākaukau ʻia o ka nui like o ka 10% m/v solution of ferric chloride R a me 5 percent m/v solution of postassium ferricyanide R. E nānā koke i nā chromatoframs.Kekahi wahi o ka chromatogram i loaʻa me ka hoʻonā hoʻāʻo, ʻokoʻa ka wahi nui, ʻaʻole i ʻoi aku ka ikaika ma mua o ka wahi o ka chromatogram i loaʻa me ka hoʻonā kuhikuhi (a) hōʻike.ʻAʻole kūpono ka hoʻāʻo inā ʻaʻole hōʻike ka chromatogram i loaʻa me ka solution reference (b), ma luna o ke kiko nui, kahi wahi ʻokoʻa i ʻoi aku ka ikaika ma mua o ke kiko o ka chromatogram i loaʻa me ka solution reference (a).
ʻAno UV [EP]
Disslove 30.0mg i ka 0.1mol/L hydrochloric acid a dilute i 100.oml me ka waika like.E hoʻoheheʻe i 10.0ml o kēia hoʻonā i 100.0ml me 0.1mol/L hydrochloric acid.Nānā ʻia ma waena o 230nm a me 350nm, hōʻike ka hopena i hoʻokahi absorption maximum ma 280nm.ʻO ka absorbance kikoʻī ma kēia kiʻekiʻe he 137 a 147, i helu ʻia me ka kuhikuhi ʻana i ka mea maloʻo.
Nalo ma ka maloo
E lawe i kēia huahana, maloʻo a hiki i ke kaumaha mau ma 105°C, ʻaʻole e ʻoi aku ke kaumaha o ke kaumaha ma mua o 1.0% (General rule 0831).
ʻO ke koena ma ka ʻāʻī (Sulfated)
E lawe i ka l.0g o Levodopa a nānā e like me ke kānāwai (General rule 0841).ʻAʻole ʻoi aku ke koena o ke koena ma mua o 0.1%.
Nā Metala Kaumaha
ʻO ke koena i waiho ʻia ma lalo o ke ʻano o ka lawe ʻana i ke koena hoʻā ahi ʻaʻole e loaʻa ma mua o 10 mau ʻāpana o ka miliona o ka metala kaumaha ke nānā ʻia e ke kānāwai (General Principles 0821, Law II).
Hōʻike pH
0.10g i 10ml o H2O lulu no 15 minuke.
Hoʻoholo maʻiʻo
E lawe i kēia huahana e pili ana i 0.lg, pololei ke kaupaona ʻana, e hoʻohui i ka anhydrous formic acid 2ml e hoʻoheheʻe, e hoʻohui i ka glacial acetic acid 20ml, lulu, hoʻohui i ka aniani violet hōʻailona 2 kulu, me ka perchloric acid titration solution (0.1 mol/L) titration i ka hopena ʻōmaʻomaʻo, a hoʻoponopono ʻia ka hopena o ka titration me kahi hoʻāʻo blank.ʻO kēlā me kēia 1 ml o ka waika perchloric titration solution (0.1 mol/L) pili i 19.72mg o C9H11N04.
JP17 Hana Hana
ʻO Levodopa, ke maloʻo, ʻaʻole i emi iho ma lalo o 98.5% o Levodopa (C9H11NO4).
Hōʻike ʻia ʻo Levodopa ma ke ʻano keʻokeʻo a i ʻole keʻokeʻo hina hina, nā kristal a i ʻole ka pauka crystalline.He ala ʻole.Hiki ke hoʻoheheʻe ʻia i ka waika formic, hiki ke hoʻoheheʻe ʻia i ka wai, a hiki ʻole ke hoʻoheheʻe ʻia i ka ethanol (95).Hoʻoheheʻe ia i ka waika hydrochloric dilute.Aia ma waena o 5.0 a me 6.5 ka pH o ka hopena saturated o Levodopa.Ka helu hehee: ma kahi o 275 ℃ (me ka decomposition).
ʻIkepili
(1) I ka 5 mL o ka hopena o Levodopa (1 i ka 1000) hoʻohui i 1mL o ninhydrin TS, a wela no 3 mau minuke i loko o ka ʻauʻau wai: ulu ka waihoʻoluʻu poni.
(2) I ka 2 mL o ka hopena o Levodopa (1 i loko o 5000) hoʻohui i 10 mL o 4-aminoantipyrine TS, a lulu: ulu ka ʻulaʻula.
(3) E hoʻoheheʻe i 3 mg o Levodopa i 0.001 mol/L hydrochloric acid TS e hana i 100 mL.E hoʻoholo i ke kiko kikoʻī o ka haʻina e like me ke kuhikuhi ʻana ma lalo o Ultravioletvisible Spectrophotometry <2.24>, a e hoʻohālikelike i ke kikoo me ka Spectrum Reference: hōʻike nā kikoʻī ʻelua i ka ikaika o ka absorption ma nā lōʻihi nalu like.
Absorbance <2.24> E 1%1cm (280 nm): 136-146 (ma hope o ka maloʻo, 30 mg, 0.001 mol / L hydrochloric acid TS, 1000 mL).
Hoʻololi Optical <2.49> [a]20D:-11.5° ~-13.0°(ma hope o ka maloʻo ʻana, 2.5 g, 1 mol/L hydrochloric acid TS, 50 mL, 100 mm).
Maemae
(1) Ka malamalama a me ka waihoʻoluʻu o ka hoʻonā-Dissolve 1.0 g o Levodopa i 20 mL o 1 mol/L hydrochloric acid TS: he akaka a kala ʻole ka hopena.
(2) Chloride <1.03>-E hoʻoheheʻe i 0.5 g o Levodopa i 6 mLof dilute nitric acid, a hoʻohui i ka wai e lilo i 50 mL.Hana i ka ho'āʻo me ka hoʻohana ʻana i kēia hoʻonā e like me ka hopena hoʻāʻo.E hoʻomākaukau i ka hopena hoʻomalu me 0.30 mL o 0.01 mol/L hydrochloricacid VS (ʻaʻole iʻoi aku ma mua o 0.021%).
(3) Sulfate <1.14>-E hoʻoheheʻe i 0.40 g Levodopa i 1 mL o ka waika hydrochloric dilute a me 30 mL o ka wai, a hoʻohui i ka wai e lilo i 50 mL.Hana i ka ho'āʻo me ka hoʻohana ʻana i kēia hoʻonā e like me ka hopena hoʻāʻo.E hoʻomākaukau i ka hoʻonā mana me 0.25 mL o 0.005 mol/L sulfuric acid VS (ʻaʻole ʻoi aku ma mua o 0.030%).
(4) Nā Metala Kaumaha <1.07>-E hoʻomau me 1.0 g o Levodopa e like me ke ʻano 2, a hana i ka hoʻāʻo.E hoʻomākaukau i ka hoʻonā hoʻomalu me 2.0 mL o ka ʻOi (ʻaʻole ʻoi aku ma mua o 20 ppm).
(5) Arsenic <1.11>-Dissolve 1.0 g o Levodopa i loko o 5 mLof dilute hydrochloric waika, a hana i ka ho'āʻo me kēia hāʻina e like me ka ho'āʻo hoʻonā (ʻaʻole i oi ma mua o 2 ppm).
(6) Nā mea pili-E hoʻoheheʻe i 0.10 g o Levodopa i 10 mL o ka sodium disulfite TS, a hoʻohana i kēia hoʻonā e like me ka hāpana hāpana.Pipet 1 mL o ka hāpana hāpana, hoʻohui i ka sodium disulfite TS e hana pono i 25 mL.Pipet 1 mL o kēia hoʻonā, e hoʻohui i ka sodium disulfite TS e hana pono i 20 mL, a e hoʻohana i kēia hopena ma ke ʻano he hopena maʻamau.Hana i ka ho'āʻo me kēia mau hoʻonā e like me ke kuhikuhi ʻana ma lalo o Thin-layer Chro-matography<2.03>.E kau i ka 5mL o kēlā me kēia hāpana hāpana a me ka hopena maʻamau ma luna o kahi pā cellulose no ka chromatography lahilahi.E hoʻomohala i ka pā me ka hui ʻana o 1-butanol, wai, acetic acid (100) a me methanol (10:5:5:1) a hiki i kahi mamao o 10 cm, a maloʻo i ka pā.E kāpīpī i ka hopena o ka ninhydrin i loko o ka acetone (1 i ka 50) ma ka pā a me ka wela ma 90 ℃ no 10 mau minuke: ʻaʻole i ʻoi aku ka ikaika o nā kiko ma mua o ka wahi nui o ka hāpana hāpana.
ʻAʻole ʻoi aku ma mua o 0.30%(1 g, 105℃,3 hola).
ʻAʻole i ʻoi aku ma mua o 0.1% (1 g).
E kaupaona pololei ma kahi o 0.3 g o Levodopa, maloʻo mua, e hoʻoheheʻe i 3 mL o ka waika formic, e hoʻohui i 80 mL o ka ʻakika acetic (100), a e hoʻokaʻawale i <2.50> me 0.1 mol/L perchloric acid VS a hiki i ka hoʻololi ʻana o ke kala o ka hopena. mai ka poni a hiki i ka uliuli-'ōmaʻomaʻo a i ka ʻōmaʻomaʻo (hōʻailona: 3 kulu o crystalviolet TS).Hana i kahi hoʻoholo hakahaka, a hana i nā hoʻoponopono e pono ai.
ʻO kēlā me kēia mL o 0.1 mol/L perchloric acid VS=19.72 mg o C9H11NO4
ʻO nā pahu a me ka mālama ʻana i nā pahu pahu-paʻa paʻa.
Waihona-kū-māmā.
Nā Code Hazard | Xn | RTECS | AY5600000 |
Nā ʻŌlelo Hoʻopilikia | 22-36/37/38-20/21/22 | F | 10-23 |
Nā ʻōlelo palekana | 26-36-24/25 | TSCA | ʻAe |
WGK Kelemānia | 3 | HS Code | 2922509099 |
Pūʻolo: ʻO ka ʻōmole, ʻeke ʻeke alumini, pahu pahu pahu, 25kg / pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:Mālamalama a me ka ea. E kūʻai i loko o nā pahu i hoʻopaʻa ʻia ma kahi hale kūʻai maloʻo, maloʻo a me ka ea mai nā mea like ʻole.Palekana mai ka malamalama, ka ea a me ka wai.
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Hoʻohana ʻia ʻo Levodopa (L-DOPA) (CAS 59-92-7) i ka mālama ʻana i ka maʻi o Parkinson.ʻO Levodopa (L-DOPA), ka lāʻau lapaʻau hilinaʻi a maikaʻi loa i hoʻohana ʻia i ka mālama ʻana i ka parkinsonism, hiki ke manaʻo ʻia he ʻano o ka lāʻau lapaʻau.Hoʻohana nui ʻia ʻo Levodopa no ka mālama ʻana i nā ʻano parkinsonism āpau koe wale nā mea pili i ka lāʻau lapaʻau antipsychotic.ʻO Levodopa ka biochemical precursor o dopamine.Hoʻohana ʻia ia e hoʻokiʻekiʻe i nā pae dopamine i ka neostriatum o nā maʻi parkinsonian.ʻAʻole hele ʻo Dopamine iā ia iho i ka pale koko-lolo a no laila ʻaʻohe hopena CNS.Eia naʻe, lawe ʻia ʻo Levodopa, ma ke ʻano he amino acid, i loko o ka lolo e nā ʻōnaehana lawe wai amino, kahi i hoʻohuli ʻia i dopamine e ka enzyme L-aromatic amino acid decarboxylase.Inā hoʻohana wale ʻia ʻo Levodopa, ua hoʻololi nui ʻia ia e ka L-aromatic amino acid decarboxylase i loko o ke akepaʻa, ka puʻupaʻa, a me ka ʻōpū o ka ʻōpū.No ka pale ʻana i kēia metabolism peripheral, ua hui pū ʻia ʻo Levodopa me Carbidopa (Sinemet), kahi mea pale decarboxylase peripheral.ʻO ka hui pū ʻana o Levodopa me Carbidopa e hoʻohaʻahaʻa i ka nui o ka pono o Levodopa a hōʻemi i nā hopena ʻaoʻao peripheral e pili ana i kāna hoʻokele.Hoʻohana nui ʻia ʻo Levodopa no ka mālama ʻana i nā ʻano parkinsonism āpau koe wale nā mea pili i ka lāʻau lapaʻau antipsychotic.Eia nō naʻe, i ka holomua ʻana o ka parkinsonism, hiki ke hoʻopōkole ʻia ka lōʻihi o ka pōmaikaʻi mai kēlā me kēia maʻi o Levodopa.Hiki i nā maʻi ke hoʻomohala i nā loli hikiwawe ʻole ma waena o ka mobility a me ka immobility (on-off effect).I loko o kekahi mau minuke, hiki i ka mea maʻi e hauʻoli ana i ka neʻe ʻana maʻamau a kokoke paha i ke ʻano maʻamau e ulu koke i kahi pae koʻikoʻi o ka parkinsonism.Loaʻa paha kēia mau hōʻailona ma muli o ka piʻi ʻana o ka maʻi a me ka nalowale o nā striatal dopamine nerve terminals.
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