Lasofoxifene Tartrate CAS 190791-29-8 Maʻemaʻe Chiral ≥99.0% Maʻemaʻe ≥98.0% (HPLC) API Maʻemaʻe Kiʻekiʻe
Hāʻawi Mea Hana me ka Maʻemaʻe kiʻekiʻe a me ka maikaʻi paʻa
Inoa Kemika: Lasofoxifene Tartrate
CAS: 190791-29-8
Lasofoxifene Tartrate (CAS: 190791-29-8) i ka mālama ʻana i ka Postmenopausal Osteoporosis
Inoa Kimia | ʻO Lasofoxifene Tartrate |
Nā huaʻōlelo like | (5R,6S)-5,6,7,8-Tetrahydro-6-phenyl-5-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-2-naphthalenol Tartrate Oporia |
Helu CAS | 190791-29-8 |
Helu CAT | RF-API20 |
Kūlana Kūʻai | Ma ka waihona, ʻoi aku ka nui o ka hana a hiki i nā haneli kilogram |
ʻĀpana Molekala | C28H31NO2.ClH |
Kaumaha Molecular | 450.019 |
Brand | Kemika Ruifu |
'ikamu | Nā kikoʻī |
Ka nana aku | Keʻokeʻo a hiki i ka pauda keʻokeʻo |
Māmā (KF) | ≤0.50% |
Nā Metala Kaumaha | ≤20ppm |
Maʻemaʻe Chiral | ≥99.0% |
Maʻemaʻe / Kaʻina Hanana | ≥98.0% (HPLC) |
Nalo ma ka maloo | ≤0.50% |
Koena ma ka Ignition | ≤0.50% |
Kūlana hoʻāʻo | Pākē Pharmacopoeia (CP);Kūlana ʻoihana |
Hoʻohana | Mea Hana Lapaʻau Hoʻoikaika (API);ʻOsteoporosis postmenopausal |
Pūʻolo: ʻO ka ʻōmole, ʻeke ʻeke alumini, pahu pahu pahu, 25kg / pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;Palekana mai ka malamalama, ka ma'ū a me ka pest infestation.
ʻO Shanghai Ruifu Chemical Co., Ltd. ka mea hana nui a me ka mea hoʻolako o Lasofoxifene Tartrate (CAS: 190791-29-8) me ke ʻano kiʻekiʻe.
ʻO Lasofoxifene Tartrate he kolu o ka hanauna, non-steroidal selective estrogen receptor modulator (SERM).Hoʻopili paʻa ʻo ia i ka ERalpha kanaka me ka waiwai IC50 o 1.5 nM a pale i ka nalowale o ka iwi ma nā ʻiole ovariectomized.I loko o nā haʻawina hauʻoli o ka osteoporosis postmenopausal, ua pili ka 0.5 mg / lā lasofoxifene me ka hōʻemi ʻana i nā pilikia o ka nonvertebral a me ka vertebral fractures, ER-positive breast cancer, coronary heart disease, a me ka hahau akā ua piʻi ka pilikia o nā hanana thromboembolic venous.Ua hōʻike pū ʻia ʻo Lasofoxifene e hana ma ke ʻano he agonist inverse ma ka CB2 cannabinoid receptor, e hōʻike ana i kona hiki ke hoʻihoʻi hou ʻia ma ke ʻano he therapeutic no nā hōʻailona kahi CB2 i pahuhopu.