LCZ696 Intermediate CAS 1426129-50-1 Maʻemaʻe ≥98.0% (HPLC) ee ≥99.0% Hale Hana Maʻemaʻe Kiʻekiʻe
Hāʻawi Kalepa LCZ696 (CAS: 936623-90-4) Nā Kūwaena Pili:
(R)-tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate CAS: 1426129-50-1
(R,E)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid CAS: 1012341-48-8
(2R,4S)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid CAS: 1012341-50-2
(2R,4S)-ethyl 5-(1,1'-biphenyl-4-yl)-4-amino-2-methylpentanoate HCl CAS: 149690-12-0
AHU-377 (hemicalcium paʻakai) CAS: 1369773-39-6
AHU-377;Sacubitril CAS: 149709-62-6
LCZ696;Entresto;ʻO ka hui ʻana o Sacubitril me Valsartan CAS: 936623-90-4
| Inoa Kimia | (R)-tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate |
| Nā huaʻōlelo like | LCZ696 Kūwaena |
| Helu CAS | 1426129-50-1 |
| Helu CAT | RF-PI169 |
| Kūlana Kūʻai | Ma ka waihona, ʻoi aku ka nui o ka hana a hiki i nā haneli kilogram |
| ʻĀpana Molekala | C20H25NO3 |
| Kaumaha Molecular | 327.42 |
| Brand | ʻO Ruifu Chemical |
| 'ikamu | Nā kikoʻī |
| Ka nana aku | Keʻokeʻo a hiki i ka pauda keʻokeʻo |
| Maʻemaʻe / Kaʻina Hanana | ≥98.0% (HPLC) |
| Enantiomeric Excess | ee: ≥99.0% |
| Māmā (KF) | ≤1.0% |
| Nā mea pili A | ≤1.0% (RRT=0.5) A=(R)-3-([1,1'-biphenyl]-4-yl)-2-aminopropan-1-ol |
| Nā mea pili B | ≤1.0% (RRT=0.85) B=Triphenylphosphine oxide |
| Nā mea ʻē aʻe | ≤1.0% |
| Huina paumaele | ≤2.0% |
| Kūlana hoʻāʻo | ʻOihana Kūlana |
| Hoʻohana | Kūwaena o LCZ696 (CAS: 936623-90-4) i ka mālama ʻana iā HFrEF |
Pūʻolo: ʻO ka ʻōmole, ʻeke ʻeke alumini, pahu pahu pahu, 25kg / pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;Palekana mai ka malamalama, ka ma'ū a me ka pest infestation.
Mea Hana me ka Maʻemaʻe kiʻekiʻe a me ka maikaʻi paʻa
Hāʻawi Kalepa LCZ696 (CAS: 936623-90-4) Nā Kūwaena Pili:
(R)-tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate CAS: 1426129-50-1
(R,E)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid CAS: 1012341-48-8
(2R,4S)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid CAS: 1012341-50-2
(2R,4S)-ethyl 5-(1,1'-biphenyl-4-yl)-4-amino-2-methylpentanoate HCl CAS: 149690-12-0
AHU-377 (hemicalcium paʻakai) CAS: 1369773-39-6
AHU-377;Sacubitril CAS: 149709-62-6
LCZ696;Entresto;ʻO ka hui ʻana o Sacubitril me Valsartan CAS: 936623-90-4
He lāʻau hoʻokolohua ʻo LCZ696 i hoʻomohala ʻia e Novartis Pharmaceutical o ʻAmelika Hui Pū ʻIa no ka mālama ʻana i nā poʻe maʻi me ka Heart Failure me ka emi ʻana o ka Ejection Fraction (HFrEF).He maʻi weliweli ka naʻau ʻole.ʻAʻole hiki i ka naʻau o ka mea maʻi ke pā i ke koko e hoʻolako i ke kino, a ʻike ʻia nā hōʻailona o ka dyspnea, ka luhi a me ka paʻa ʻana o ka wai me ka mālie, a laila e hoʻonui nui ʻia, e pili ana i ka maikaʻi o ke ola.Hiki i ka LCZ696 ke hoʻonui i ka pale kūlohelohe o ke kino e kū'ē i ka pau ʻole o ka naʻau, a me ka hoʻonui ʻana i ke kiʻekiʻe o nā peptides natriuretic a me nā peptides vasoactive endogenous, a ke kāohi i ka ʻōnaehana renin-angiotensin-aldosterone (RAAS).Ua hui pū ʻo LCZ696 me Novartis's Hypertension Medication (Diovan, generic name: valsartan) a me ka lāʻau hoʻokolohua AHU-377.Hoʻopaʻa ʻo AHU377 i ke ʻano o nā peptides ʻelua e hoʻohaʻahaʻa i ke koko.Hoʻomaikaʻi ʻo Diovan i ka vasodilation a hoʻoulu i ke kino e hoʻokuʻu i ka sodium a me ka wai.
