Lesinurad (RDEA 594) CAS 878672-00-5 Maʻemaʻe >99.5% (HPLC) Hōʻike 98.0~102.0%
ʻO Shanghai Ruifu Chemical Co., Ltd. ka mea hana nui o Lesinurad (RDEA 594) (CAS: 878672-00-5) me ke kūlana kiʻekiʻe.Hiki iā Ruifu Chemical ke hāʻawi aku i ka honua holoʻokoʻa, ke kumukūʻai hoʻokūkū, ka lawelawe maikaʻi loa, ka liʻiliʻi a me ka nui nui i loaʻa.E kūʻai aku iā Lesinurad a me nā mea waena,Please contact: alvin@ruifuchem.com
| Inoa Kimia | Lesinurad |
| Nā huaʻōlelo like | 2-[[5-Bromo-4-(4-Cyclopropylnaphthalen-1-yl)-4H-1,2,4-Triazol-3-yl]thio]acetic Acid;2-[[5-Bromo-4-(4-Cyclopropyl-1-Naphthalenyl)-4H-1,2,4-Triazol-3-yl]thio]-Acetic Acid;RDEA 594;RDEA-594;RDEA594;Zurampic |
| Kūlana Kūʻai | Ma ke Kahua, Hana Hana Kūʻai |
| Helu CAS | 878672-00-5 |
| ʻĀpana Molekala | C17H14BrN3O2S |
| Kaumaha Molecular | 404.28 g/mol |
| Lae hehee | >171℃(Dek.) |
| ʻO ka mānoanoa | 1.72±0.10 g/cm3 |
| COA & MSDS | Loaʻa |
| Ke kumu | Shanghai, Kina |
| Brand | Kemika Ruifu |
| Nā mea | Nā Kūlana Nānā | Nā hualoaʻa |
| Ka nana aku | Keʻokeʻo a hiki i ka pauda keʻokeʻo | Pada Keʻokeʻo Paʻa |
| ʻIkepili | ʻO ka manawa paʻa o ka piko nui o ka hāpana hāpana pili i ka maʻamau kuhikuhi | Hoʻokō |
| Wai na Karl Fischer | <0.50% | 0.14% |
| Koena ma ka Ignition | <0.10% | 0.03% |
| Nā Metala Kaumaha (Pb) | ≤10ppm | <10ppm |
| Nā mea pili (HPLC) | ||
| ʻO ka haumia hoʻokahi nui loa | <0.20% | 0.07% |
| Huina paumaele | <1.00% | 0.24% |
| Maʻemaʻe / Kaʻina Hanana | >99.5% (HPLC Area) | 99.76% |
| Hoʻāʻo | 98.0~102.0% | 99.6% |
| Infrared Spectrum | Kūlike i ka hoʻolālā | Hoʻokō |
| NMR Spectrum | Kūlike i ka hoʻolālā | Hoʻokō |
| Ka hopena | Ua hoʻāʻo ʻia ka huahana a hoʻokō me nā kikoʻī i hāʻawi ʻia | |
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Kūlana mālama:E hoʻopaʻa paʻa i ka pahu a mālama i loko o kahi hale kūʻai maloʻo a maloʻo (2 ~ 8 ℃) a me kahi hale kūʻai maikaʻi mai nā mea like ʻole.E pale i ka malamalama a me ka wai.
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Pehea e kūʻai ai?E ʻoluʻolu e kelepona maiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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Ua ʻae ʻia ʻo Lesinurad (RDEA 594) (CAS: 878672-00-5) e ka US Food and Drug Administration (FDA) ma Dekemaba 22, 2015, a laila ʻae ʻia e ka European Medicines Agency (EMA) ma Pepeluali 18, 2016. Ua kūkulu mua ʻia ka pūhui e Ardea.Ua loaʻa iā AstraZeneca ka hui ma 2012, a ua loaʻa iā ia ka huahana.ʻO ka inoa kālepa o ka lāʻau lapaʻau ʻo Zurampic® ma ʻAmelika Hui Pū ʻIa a me ʻEulopa.ʻO Lesinurad ka mea hoʻopaneʻe mua o ka urate reuptake transporter (URAT1) i ʻāpono ʻia, i hui pū ʻia me ka xanthine oxidase inhibitors e mālama i ka hyperuricemia-related gout.
ʻO Lesinurad, inoa kālepa Zurampic.ʻO Lesinurad i hui pū me ka xanthine oxidase inhibitor (XOI) no ka hyperuricemic gout syndrome.ʻO kāna hana o ka hana, ʻo ia ke kōkua i nā puʻupaʻa e hoʻokuʻu i ka ʻakika uric, a hana ia ma ke kāohi ʻana i ka hana o nā transporters i komo i ka reabsorption uric acid i loko o nā puʻupaʻa.
Hoʻopaʻa ʻo Lesinurad i ka hana halihali uric acid (IC50 = 3.36 μM) o hURAT1 (URAT1 kanaka), ʻoi aku ma mua o 20 mau manawa i ka hopena inhibitory ma rURAT1 (rat URAT1) (IC50 = 74.84 μM).Hoʻopili ʻo Lesinurad i ka hURAT1 ma o ka launa pū ʻana o ke koena amino acid Phe365.
