Lopinavir CAS 192725-17-0 API Anti-HIV HIV Protease Inhibitor COVID-19 Maʻemaʻe Kiʻekiʻe
Hāʻawi Mea Hana me ka Maʻemaʻe kiʻekiʻe a me ka maikaʻi paʻa
Inoa Kemika: Lopinavir
CAS: 192725-17-0
ʻO kahi mea hoʻomākaʻikaʻi protease HIV-1 maikaʻi loa, koho
Huahana noiʻi pili COVID-19
API no ke kūlana kiʻekiʻe, hana kālepa
Inoa Kimia | Lopinavir |
Nā huaʻōlelo like | LPV;ABT-378;Kaletra |
Helu CAS | 192725-17-0 |
Helu CAT | RF-API73 |
Kūlana Kūʻai | Ma ka waihona, ʻoi aku ka nui o ka hana a hiki i nā haneli kilogram |
ʻĀpana Molekala | C37H48N4O5 |
Kaumaha Molecular | 628.81 |
Waihona Loihi | E mālama i ka lōʻihi ma 2-8 ℃ |
Brand | Kemika Ruifu |
'ikamu | Nā kikoʻī |
Ka nana aku | Keʻokeʻo a hiki i ka pauda keʻokeʻo |
Ka hikiwawe | Hiki ke hoʻoheheʻe ʻia i loko o ka Methanol a me ka Ethanol, hiki ke hoʻoheheʻe ʻia ma 2-Propanol |
ʻIkepili IR | ʻO ka spectrum absorption infrared o ka hāpana hoʻāʻo e kūlike me ka spectrum o ka maʻamau kuhikuhi |
ʻIke HPLC | ʻO ka manawa paʻa o ka hāpana hoʻāʻo e pili ana i ka maʻamau kuhikuhi |
Waiwai (na KF) | ≤4.0% |
Hoʻololi Optical kikoʻī | -22.0° a i -26.0° |
Koena ma ka Ignition | ≤0.20% |
Nā Metala Kaumaha | ≤20ppm |
Lae hehee | 124.0 a 127.0 ℃ |
Lehu Sulphated | ≤0.20% |
Koena Solvent (Ethanol) | ≤0.50% |
Na mea pili | (HPLC, Wahi%) |
haumia 1 | |
haumia B (RRT=0.07) | ≤0.20% |
haumia I (RRT=1.10) | ≤0.20% |
ʻO nā mea haumia ʻē aʻe | ≤0.10% |
haumia 2 | ʻO nā mea haumia ʻē aʻe ≤0.10% |
Huina haumia mai ke kaʻina hana 1 a me 2 | ≤0.70% |
Huina paumaele | ≤1.0% |
ʻIke (na HPLC) | 98.0%~102.0% |
Kūlana hoʻāʻo | Kūlana ʻoihana |
Hoʻohana | Koho Peptidomimetic HIV-1 Protease Inhibitor, COVID-19 Huahana Noi'i Pili |
Pūʻolo: ʻO ka ʻōmole, ʻeke ʻeke alumini, pahu pahu pahu, 25kg / pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;Palekana mai ka malamalama, ka ma'ū a me ka pest infestation.
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ʻO Lopinavir (ABT-378) he mea ikaika loa, koho peptidomimetic inhibitor o ka HIV-1 protease, me Kis o 1.3 a 3.6 pM no ka protease HIV-ano hihiu a me ka mutant.Hana ʻo Lopinavir ma ka hopu ʻana i ka oʻo ʻana o ka maʻi HIV-1 ma laila e pale ai i kāna maʻi maʻi.ʻO Lopinavir kekahi mea hoʻopaneʻe SARS-CoV 3CLpro me kahi IC50 o 14.2 μM.ʻO Lopinavir kahi antiretroviral o ka papa protease inhibitor.ʻO ka pale ʻana i ka protease HIV-1 ka mea e pale ai i ka wehe ʻana o ka polyprotein precursor viral a me ka hopena i ka hoʻokuʻu ʻana i nā virion ʻoi ʻole, ʻaʻohe infectious.ʻO kahi ʻāpana o ka lāʻau hui e mālama i ka maʻi HIV/AIDS.ʻO Lopinavir, ke ono o ka HIV protease inhibitor ma ka papa "navir", ua hoʻokumu ʻia i ka coformulation me ritonavir, kahi mea hoʻopaneʻe protease HIV i kūʻai mua ʻia (Abbott, 1996);ua hoʻokomo ʻia kēia ʻano hana kumu ʻo Kaletra no ka hoʻohana ʻana me ka nucleoside a i ʻole ka nucleoside reverse transcriptase inhibitors no ka mālama ʻana i ka maʻi AIDS i nā pākeke a me nā keiki.ʻO Lopinavir kahi pūhui peptidomimetic me kahi kumu hoʻohālike e like me ka ritonavir, kahi i hoʻokomo ʻia ai nā pūʻulu terminal, ʻoi aku ka valine i hoʻololi ʻia e nā kaʻina hana hoʻohui peptide.ʻO Lopinavir kahi mea hoʻokūkū hoʻokūkū ikaika o ka protease HIV-I e hōʻike ana i ka mana kiʻekiʻe e kūʻē i nā mutations kūʻē ritonavir.I kekahi mau holoholona holoholona, nā haʻawina pharmacokinetic me ka hui lopinavirlritonavir i hōʻike ʻia ua hoʻomaikaʻi maikaʻi ʻia nā waiwai haʻahaʻa o lopinavir i mua o ritonavir, ma ke ʻano o Cmax a me ka lōʻihi o ka hana.
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