Lopinavir CAS 192725-17-0 API Anti-HIV HIV Protease Inhibitor COVID-19 Maʻemaʻe Kiʻekiʻe

ʻO Lopinavir (ABT-378) he mea ikaika loa, koho peptidomimetic inhibitor o ka HIV-1 protease, me Kis o 1.3 a 3.6 pM no ka protease HIV-ano hihiu a me ka mutant.Hana ʻo Lopinavir ma ka hopu ʻana i ka oʻo ʻana o ka maʻi HIV-1 ma laila e pale ai i kāna maʻi maʻi.ʻO Lopinavir kekahi mea hoʻopaneʻe SARS-CoV 3CLpro me kahi IC50 o 14.2 μM.ʻO Lopinavir kahi antiretroviral o ka papa protease inhibitor.ʻO ka pale ʻana i ka protease HIV-1 ka mea e pale ai i ka wehe ʻana o ka polyprotein precursor viral a me ka hopena i ka hoʻokuʻu ʻana i nā virion ʻoi ʻole, ʻaʻohe infectious.ʻO kahi ʻāpana o ka lāʻau hui e mālama i ka maʻi HIV/AIDS.ʻO Lopinavir, ke ono o ka HIV protease inhibitor ma ka papa "navir", ua hoʻokumu ʻia i ka coformulation me ritonavir, kahi mea hoʻopaneʻe protease HIV i kūʻai mua ʻia (Abbott, 1996);ua hoʻokomo ʻia kēia ʻano hana kumu ʻo Kaletra no ka hoʻohana ʻana me ka nucleoside a i ʻole ka nucleoside reverse transcriptase inhibitors no ka mālama ʻana i ka maʻi AIDS i nā pākeke a me nā keiki.ʻO Lopinavir kahi pūhui peptidomimetic me kahi kumu hoʻohālike e like me ka ritonavir, kahi i hoʻokomo ʻia ai nā pūʻulu terminal, ʻoi aku ka valine i hoʻololi ʻia e nā kaʻina hana hoʻohui peptide.ʻO Lopinavir kahi mea hoʻokūkū hoʻokūkū ikaika o ka protease HIV-I e hōʻike ana i ka mana kiʻekiʻe e kūʻē i nā mutations kūʻē ritonavir.I kekahi mau holoholona holoholona, ​​​​nā haʻawina pharmacokinetic me ka hui lopinavirlritonavir i hōʻike ʻia ua hoʻomaikaʻi maikaʻi ʻia nā waiwai haʻahaʻa o lopinavir i mua o ritonavir, ma ke ʻano o Cmax a me ka lōʻihi o ka hana.