ʻO Losartan Potassium CAS 124750-99-8 API Hale Hana Antihypertensive Maʻemaʻe Kiʻekiʻe
Hāʻawi i ka Losartan Potassium a me nā Intermediates pili me ka maikaʻi kiʻekiʻe
ʻO Losartan Potassium CAS 124750-99-8
2-Butyl-4-Chloro-5-Formylimidazole (BCFI) CAS 83857-96-9
| Inoa Kimia | ʻO ka pāpaʻi losartan |
| Nā huaʻōlelo like | DuP 753;Cozaar;2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]imidazole-5-methanol Potassium Salt |
| Helu CAS | 124750-99-8 |
| Helu CAT | RF-API98 |
| Kūlana Kūʻai | Ma ka waihona, hoʻonui ʻia a hiki i nā tona |
| ʻĀpana Molekala | C22H22ClKN6O |
| Kaumaha Molecular | 461.01 |
| Lae hehee | 263.0~265.0 ℃ |
| Ka hikiwawe | Hiki ke hoʻoheheʻe ʻia i ka wai a me ka methanol, hiki ke hoʻoheheʻe ʻia i ka Acetonitrile. |
| Brand | Kemika Ruifu |
| 'ikamu | Nā kikoʻī |
| Ka nana aku | Keʻokeʻo a ʻaneʻane keʻokeʻo Crystalline pauda |
| ʻIkepili A | Infrared Absorption: Pono e like me ka Reference Standard |
| ʻIkepili B | ʻO ka Ultraviolet absorption: Pono e like me ka Reference Standard |
| Hoao no ka Potasuma | Pono pono |
| Waiwai (KF) | ≤0.50% |
| Nā Metala Kaumaha | ≤10ppm |
| Nā mea pili (HPLC) | |
| ʻO kēlā me kēia haumia kanaka | ≤0.20% |
| Huina paumaele | ≤0.50% |
| Nā mea hoʻoheheʻe koena (GC) | |
| Cyclohexane | ≤0.10% |
| Isopropyl Alcohol | ≤0.20% |
| ʻO ke ʻano o ka hoʻāʻo ʻana | 98.5~101.0% (HPLC, helu ʻia ma ka anhydrous, solvent-free kumu) |
| N-Nitrosodiethylamine | ≤0.177ppm (NDEA) |
| N-Nitrosodimethylamine | ≤0.640ppm (NDMS) |
| Ka nui o ka ʻāpana | 90% emi iho ma mua o 38 Microns |
| Ola Pahu | 24 mahina |
| Kūlana hoʻāʻo | Kūlana ʻoihana |
| Hoʻohana | API, Angiotensin II Receptor Antagonist Antihypertensive |
Pūʻolo: ʻO ka ʻōmole, ʻeke ʻeke alumini, pahu pahu pahu, 25kg / pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;Palekana mai ka malamalama, ka ma'ū a me ka pest infestation.
ʻO Losartan Potassium ka mea mua loa a koho i ka non-peptide angiotensin II receptor type 1 (AT1) antagonist i hoʻolauna ʻia i ka mākeke ma ke ʻano he antihypertensive waha i hoʻokahi lā.ʻO ka manaʻo e pale ai i ka 50% o ka paʻa ʻana o ka angiotensin II (IC50) he 20 nM.Hoʻopilikia ʻo Losartan (40 μM) i ka ISC akā pale i ka hopena o ANGII ma ISC.Hoʻemi nui ʻo Losartan i ka Ang II-mediated cell proliferation in endometrial cancer cells.ʻO ka hui pū ʻana o losartan a me anti-miR-155 he hopena antiproliferative ʻoi aku ka nui ma mua o kēlā me kēia lāʻau lapaʻau wale nō.Hoʻopili ʻia ia e hana i ka 5-carboxylic acid metabolite (EXP3174) a hōʻike ʻia e hoʻohaʻahaʻa i ke koko.Ke noiʻi ʻia nei ia ma ke ʻano he lāʻau lapaʻau no COVID-19 no kona hiki ke hoʻēmi a hōʻemi paha i nā hōʻailona o COVID-19.
1. No ka mālama ʻana i ka hypertension koʻikoʻi, hiki ke hoʻohana wale ʻia a i hui pū ʻia me nā lāʻau antihypertensive ʻē aʻe (e like me ka diuretics).2. No ka hoʻomaʻamaʻa ʻana i ka pau ʻole o ka naʻau, hiki ke hoʻohana wale ʻia a i hui pū ʻia me nā lāʻau cardiotonic a diuretic Chemicalbook.3. Ka pale ʻana i ka hahau ʻana i nā maʻi me ka hypertension a me ka hypertrophy ventricular hema.4. Hoʻohana ʻia ia e hoʻolōʻihi i ka holomua o ka nephropathy i nā maʻi me ka maʻi diabetes type 2 e pili ana i ka nephropathy a me ke kiʻekiʻe.
