Methyl 2-Oxoindoline-6-Carboxylate CAS 14192-26-8 Maʻemaʻe >99.0% (HPLC) Nintedanib Esylate Intermediate Factory
ʻO Shanghai Ruifu Chemical Co., Ltd. ka mea hana nui a me ka mea kūʻai aku o Methyl 2-Oxoindoline-6-Carboxylate (CAS: 14192-26-8) me ke kūlana kiʻekiʻe, hana pāʻoihana.
Inoa Kimia | Methyl 2-Oxoindoline-6-Carboxylate |
Nā huaʻōlelo like | 2-Oxoindoline-6-Carboxylic Acid Methyl Ester;Methyl Oxindole-6-Carboxylate |
Helu CAS | 14192-26-8 |
Helu CAT | RF-PI1524 |
Kūlana Kūʻai | Ma ka waihona, hoʻonui ʻia a hiki i nā tona |
ʻĀpana Molekala | C10H9NO3 |
Kaumaha Molecular | 191.19 |
Lae hehee | 184.0~190.0 ℃ |
Brand | Kemika Ruifu |
'ikamu | Nā kikoʻī |
Ka nana aku | Melemele māmā i ka pauda ʻulaʻula |
1 H NMR Spectrum | Kūlike me ka hoʻolālā |
Maʻemaʻe / Kaʻina Hanana | >99.0% (HPLC) |
Nalo ma ka maloo | <1.00% |
Huina paumaele | <1.00% |
Kūlana hoʻāʻo | Kūlana ʻoihana |
Hoʻohana | Ka waena o Nintedanib Esylate (CAS: 656247-18-6) |
Methyl 2-Oxoindoline-6-Carboxylate (CAS: 14192-26-8) Alanui Synthetic
Pūʻolo: ʻO ka ʻōmole, ʻeke ʻeke alumini, 25kg / pahu pahu pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;E pale i ka malamalama a me ka wai.
ʻO Methyl 2-Oxoindoline-6-Carboxylate (CAS: 14192-26-8) kahi mea waena i hoʻohana ʻia no ka hoʻomākaukau ʻana i ka Nintedanib Esylate (CAS: 656247-18-6).ʻO Nintedanib Esylate kahi mea hoʻopaneʻe waha triple angiokinase i hoʻomohala ʻia e Boehringer Ingelheim e kuhikuhi ana i nā ala proangiogenic a me pro-fibrotic i hoʻopili ʻia e ka vascular endothelial growth factor receptor, fibroblast growth factor receptor a me plateletderived growth factor receptor ʻohana, a me Src a me Flt-3 kinase.Ua ʻae ʻia ʻo Nintedanib Esylate no ka mālama ʻana i ka idiopathic pulmonary fibrosis (IPF), kahi maʻi i ʻeha nui ʻia ka māmā i ka manawa, e ka US FDA i ʻOkakopa 2014 a e ka EMA i Ianuali 2015. Ua hāʻawi ka FDA i ka nintedanib esylate wikiwiki wikiwiki. , ka loiloi mua, huahana keiki makua ʻole, a me nā inoa holomua.Ua ʻae ʻia hoʻi e ka EMA i Nowemapa 2014 no ka mālama ʻana i ka maʻi maʻi ʻōpū liʻiliʻi liʻiliʻi me ka docetaxel ma hope o ka chemotherapy laina mua.