Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate CAS 328086-60-8 PF-07321332 Boceprevir Intermediate

ʻO ka wehewehe pōkole:

Inoa Kemika: Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl] propanoate

CAS: 328086-60-8

Ke 'ano: Pada ke'oke'o i ka pauka ke'oke'o

Kūwaena o PF-07321332 Paxlovid (CAS 2628280-40-8) a me Boceprevir (CAS 394730-60-0)

ʻO ke kūlana kiʻekiʻe, ka hana kālepa

Inquiry: alvin@ruifuchem.com

E hoʻouna i ka leka uila iā mākou

Huahana Huahana

Nā Huahana Pili

Huahana Huahana

wehewehe:

Mea Kūʻai Kūʻai PF-07321332 Paxlovid E pili ana i waena me ke kūlana kiʻekiʻe.
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Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate CAS 328086-60-8
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Na Waiwai Kemika:

Inoa Kimia	Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate
Nā huaʻōlelo like	Methyl (S)-2-((tert-butoxycarbonyl)amino)-3-((S)-2-oxopyrrolidin-3-yl)propanoate;(αS,3S)-α-[(tert-Butyloxycarbonyl)aMino]-2-oxo-3-pyrrolidinepropanoic acid Methyl Ester;(S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-((S)-2-oxopyrrolidin-3-yl)propanoate
Helu CAS	328086-60-8
Helu CAT	RF-PI317
Kūlana Kūʻai	Ma ka waihona, ʻoi aku ka nui o ka hana a hiki i nā haneli kilogram
ʻĀpana Molekala	C13H22N2O5
Kaumaha Molecular	286.33
Brand	Kemika Ruifu

Nā kikoʻī:

'ikamu	Nā kikoʻī
Ka nana aku	Keʻokeʻo a hiki i ka pauda keʻokeʻo
ʻIkepili A	IR: E like me ka mea kuhikuhi
ʻIkepili B	Manawa Hoʻopaʻa: E like me ka mea kuhikuhi
Nalo ma ka maloo	≤1.0%
Koena ma ka Ignition	≤0.20%
Hoʻokahi haumia	≤0.50%
Huina paumaele	≤2.0%
Nā Metala Kaumaha (Pb)	≤20ppm
Maemae	≥98.0%
Kūlana hoʻāʻo	Kūlana ʻoihana
Hoʻohana	Kūwaena o PF-07321332 Paxlovid (CAS 2628280-40-8) a me Boceprevir (CAS 394730-60-0)

Pūʻolo a me ka waiho ʻana:

Pūʻolo: ʻO ka ʻōmole, ʻeke ʻeke alumini, pahu pahu pahu, 25kg / pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.

Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;Palekana mai ka malamalama, ka ma'ū a me ka pest infestation.

Pono:

FAQ:

Noi:

ʻO Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl] propanoate (CAS 328086-60-8) ka mea waena o PF-07321332 Paxlovid (CAS 2628280-40 -8) a me Boceprevir (CAS 394730-60-0).ʻO PF-07321332, ka mea koʻikoʻi o Paxlovid (PF-07321332 a me Ritonavir) he moho antiviral waha COVID-19 i hoʻokolokolo ʻia, he 3C-like protease (3CLPRO) i hiki i ka waha me nā hopena antiviral ikaika e kūʻē i ka maʻi SARS-CoV-2. a me COVID-19.Ma ka lā 6 o Nowemapa 2021, hoʻolaha ʻo Pfizer ua hōʻemi nui ʻo Paxlovid i ka haukapila a me ka make, e pili ana i kahi loiloi interim o ka Phase 2/3 EPIC-HR (Evaluation of Protease Inhibition for COVID-19 in High-Risk Patients) randomized, double-blind study. o nā poʻe maʻi makua ʻole i hoʻokipa ʻia me COVID-19, ka poʻe i pilikia nui i ka holomua ʻana i ka maʻi koʻikoʻi.ʻO Boceprevir (EBP-520) he mea hoʻopaʻa protease HCV (Ki=14 nM) no ka mālama ʻana i ka maʻi maʻi hepatitis C.ʻO Boceprevir me ka interferon pegylated a me ka ribavirin (PegIFN/RBV) i hiki ai ke hoʻomaikaʻi i nā helu pane virological mau o nā maʻi me ka genotype 1 HCV.Hoʻopili ʻo Boceprevir me ka immunosuppressive therapy (IT) ma ke kāohi ʻana i ka enzyme cytochrome P450 3A.