N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1 Maʻemaʻe >99.0% (HPLC) Afatinib Dimaleate Intermediate Factory

ʻO ka wehewehe pōkole:

Inoa Kemika: N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine

CAS: 162012-67-1

Maʻemaʻe: >99.0% (HPLC)

ʻAno: Melemele māmā i ka pauda melemele

Waena o Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

E hoʻouna i ka leka uila iā mākou

Huahana Huahana

Nā Huahana Pili

Huahana Huahana

wehewehe:

ʻO Ruifu Nā Kūwaena Hoʻolako Kimia o Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-hoʻokahi CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl) oxy)quinazolin-4-AmineCAS 314771-88-5

Na Waiwai Kemika:

Inoa Kimia	N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine
Nā huaʻōlelo like	N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitro-4-Quinazolinamine;(3-Chloro-4-Fluorophenyl)(7-Fluoro-6-Nitroquinazolin-4-yl)amine;4-(3-Chloro-4-Fluoroanilino)-7-Fluoro-6-Nitroquinazoline;ʻO Afatinib Intermediate A
Helu CAS	162012-67-1
Helu CAT	RF-PI2026
Kūlana Kūʻai	Ma ka waihona, hoʻonui ʻia a hiki i nā tona
ʻĀpana Molekala	C14H7ClF2N4O2
Kaumaha Molecular	336.68
ʻO ka ʻike	Paʻi Lewa, Paʻa Wela
Lae hehee	242.0~244.0 ℃
Lae paila	489 ℃
ʻO ka mānoanoa	1.616
Brand	Kemika Ruifu

Nā kikoʻī:

'ikamu	Nā kikoʻī
Ka nana aku	Melemele māmā i ka pauda melemele
Maʻemaʻe / Kaʻina Hanana	>99.0% (HPLC)
Nalo ma ka maloo	<0.50%
Koena ma ka Ignition	<0.20%
Na mea pili
Ka haumia o ke kanaka	<0.50%
Huina paumaele	<1.00%
Nā Metala Kaumaha	≤20ppm
Infrared Spectrum	Kūlike i ka hoʻolālā
Proton NMR Spectrum	Kūlike i ka hoʻolālā
Kūlana hoʻāʻo	Kūlana ʻoihana
Hoʻohana	Waena o Afatinib Dimaleate (CAS: 850140-73-7)

Pūʻolo a me ka waiho ʻana:

Pūʻolo: ʻOmole, ʻeke ʻeke Aluminum, 25kg / pahu pahu pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.

Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;E pale i ka malamalama a me ka wai

Pono:

FAQ:

Noi:

ʻO N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine (CAS: 162012-67-1) he mea waena i ka synthesis o Afatinib Dimaleate (CAS: 850140-73-7) .ʻO Afatinib Dimaleate kahi ʻano paʻakai o Afatinib.ʻO Afatinib ka lua o ka hanauna, i lawelawe waha ʻia, i hoʻohuli ʻole ʻia o ka ʻohana ErbB o tyrosine kinases.Mechanism of ActionAfatinib downregulates ErbB signing by covalently binding to the kinase domains of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor (HER) 2 a me HER4, ka hopena i ka hiki ole ke hoʻololi i ka tyrosine kinase autophosphorylation;ke kaʻe nei i ka transphosphorylation o HER3.Ua ʻae ʻia ʻo Afatinib ma ke ʻano he monotherapy no ka mālama ʻana i ka EGFR tyrosine kinase inhibitor (TKI) -naive adults me locally advanced or DefinitionChEBI: He paʻakai maleate i loaʻa ma ka hoʻohui ʻana i ka afatinib me ʻelua mau molar like o ka maleic acid.Hoʻohana ʻia no ka lāʻau lapaʻau mua o nā poʻe maʻi me ka maʻi maʻi ʻaʻa ʻole liʻiliʻi liʻiliʻi metastatic.