N-Cbz-L-Valine CAS 1149-26-4 Z-Val-OH Maʻemaʻe >99.0% (HPLC) Hale Hana

ʻO N-Cbz-L-Valine (Z-Val-OH) (CAS: 1149-26-4) kahi ʻano L-Valine i pale ʻia e N-Cbz.ʻO N-Cbz-L-Valine kahi valine i pale ʻia e Cbz a hoʻohana nui ʻia i ke kahua o ka synthesis lāʻau.ʻO L-Valine kahi waikawa amino koʻikoʻi i hoʻohana ʻia ma ke ʻano he mea hoʻohui i nā mea hoʻonaninani, nā lāʻau lapaʻau, a me nā huahana hānai holoholona.He mea nui hoʻi ʻo L-Valine no ka ulu ʻana a me ka detoxification amonia i nā kānaka.
ʻO Z-Amino Acid, hiki ke hoʻohana ʻia i ka peptide synthesis, hiki ke hoʻohana ʻia ma ke ʻano he synthesis organik intermediate, pharmaceutical intermediate, biochemical reagent a chemical reagent.
Hiki ke hoʻohana ʻia ʻo N-Cbz-L-Valine i ka hana ʻana i nā API e like me Imatinib, Valaciclovir.
Hoʻomākaukau e lawe i 1.17Kg (10mol) o L-Valine, 5L o 2mol/L sodium hydroxide solution a me 1.06Kg (10mol) o ka sodium carbonate i loko o kahi ipu 20L reaction, e hoʻomaka i ka hoʻoulu ʻana, ma hope o ka hoʻoheheʻe ʻia ʻana o L-Valine. ka hoʻonā i lalo o 0 ℃, a kulu 1 i loko o 2.05Kg(12mol) o benzyl chloroformate, 4-dioxane solution 5L, mālama ʻia ka mahana o ka hopena i ke kaʻina hoʻoheheʻe ma lalo o 20℃, ma hope o ka hāʻule ʻana, he 8h ka hopena ma ka lumi. mahana wela.I ka pau ʻana o ka hopena, lawe ʻia ka wai hopena me ka dichloromethane 2.5L, hoʻolei ʻia ka māhele organik, hoʻoluʻu ʻia ka pae wai i lalo o 10 ℃, hoʻokuʻu ʻia ka waika hydrochloric concentrated a hiki i ka pH = 2, a laila hoʻoulu ʻia ma 10 ℃ no 30min. , He nui ka nui o ke keʻokeʻo paʻa ua precipitated, filtration ua laweʻia, i ka kānana koena ua holoiʻia me ka wai, ka keʻokeʻo paʻa hoʻokomo i loko o ka vacuum maloʻo umu e maloʻo, a me ka hua 93.7%.