N(4)-Hydroxycytidine CAS 3258-02-4 EIDD-1931 NHC Kūlana Kiʻekiʻe
Hoʻolako me ka maʻemaʻe kiʻekiʻe a me ka maikaʻi paʻa
Inoa Kemika: N(4)-Hydroxycytidine;EIDD-1931 (NHC)
CAS: 3258-02-4
ʻO kahi metabolite ikaika o Molnupiravir, kahi mea hoʻohiki COVID-19
| Inoa Kimia | N(4)-Hydroxycytidine |
| Nā huaʻōlelo like | EIDD-1931 (NHC);β-D-N4-Hydroxycytidine |
| Helu CAS | 3258-02-4 |
| Helu CAT | RF-PI309 |
| Kūlana Kūʻai | Ma ke Kahua, Hoʻonui ʻia i nā Kilograms |
| ʻĀpana Molekala | C9H13N3O6 |
| Kaumaha Molecular | 259.22 |
| Lae hehee | 169.0~172.0 ℃ |
| Ka hikiwawe | Hiki ke hoʻoheheʻe ʻia i 100 mM i DMSO a i 50 mM i ka wai |
| ʻO ka mānoanoa | 1.93±0.1 g/cm3 |
| Brand | Kemika Ruifu |
| 'ikamu | Nā kikoʻī |
| Ka nana aku | Keʻokeʻo a hiki i ka pauda keʻokeʻo |
| NMR | Kūlike me ka Hoʻolālā |
| Maʻemaʻe / Kaʻina Hanana | >98% (HPLC) |
| Nalo ma ka maloo | ≤1.0% |
| Hoʻokahi haumia | ≤0.50% |
| Nā Metala Kaumaha | ≤20ppm |
| Kūlana hoʻāʻo | Kūlana ʻoihana |
| Hoʻohana | He metabolite ikaika o Molnupiravir (EIDD-2801), he mea hoʻopaneʻe COVID-19 |
Pūʻolo: ʻO ka ʻōmole, ʻeke ʻeke alumini, pahu pahu pahu, 25kg / pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;Palekana mai ka malamalama, ka ma'ū a me ka pest infestation.
ʻO N(4)-Hydroxycytidine (EIDD-1931, β-d-N4-hydroxycytidine, NHC, CAS 3258-02-4) he metabolite ikaika o EIDD-2801, he mea hoʻopaneʻe COVID-19.Loaʻa i ka EIDD-1931 (NHC) ka hana antiviral ākea ākea e kūʻē i nā coronaviruses he nui, me SARS-CoV-2, MERS-CoV, SARS-CoV, a me nā hui zoonotic pili 2b a i ʻole 2c Bat-CoV me ka awelika IC50 o 0.15 μM, a me Ua hoʻonui ʻia ka ikaika e kūʻē i kahi coronavirus e kū nei i nā mutations kū'ē i ka nucleoside analog inhibitor remdesivir.I nā ʻiole i loaʻa i ka maʻi SARS-CoV a i ʻole MERS-CoV, ʻelua prophylactic a me ka hoʻokele therapeutic o Molnupiravir (EIDD-2801), kahi NHC-prodrug hiki i ka waha (β-D-N4-hydroxycytidine-5'-isopropyl ester), hoʻomaikaʻi i ka hana pulmonary. , a ua ho'ēmi i ka helu virus a me ke kaumaha o ke kino.Hoʻemi ʻia nā hua MERS-CoV i loko o ka vitro a i loko o ka vivo i pili me ka hoʻonui ʻana o ka hoʻololi ʻana i ka pinepine o ka hoʻololi ʻana i loko o ka RNA cell host akā ʻaʻole ia e kākoʻo ana i ke ʻano o ka mutagenesis lethal ma CoV.ʻO ka mana o NHC/EIDD-2801 e kūʻē i nā coronaviruses a me ka bioavailability waha e hōʻike ana i kona pono pono e like me ka antiviral maikaʻi e kūʻē iā SARS-CoV-2 a me nā coronaviruses zoonotic e hiki mai ana.
