Naproxen CAS 22204-53-1 Maʻemaʻe >99.5% (HPLC)

ʻO ka Naproxen (CAS: 22204-53-1) he lāʻau anti-inflammatory non-steroidal, he PG synthase inhibitor, hiki ke kāohi i ka prostaglandin synthetase, he analgesic koʻikoʻi a me nā hopena antipyretic, wikiwiki a piha ka absorption waha, 2 i 4 mau hola ma hope o ka hoʻopaʻa ʻana, hiki i ka pae plasma ke kiʻekiʻe, i loko o ke koko, ʻoi aku ma mua o 99% i hoʻopaʻa ʻia i nā protein plasma, t1/2 he 13 a 14 mau hola, ma kahi o 95% e hoʻokuʻu ʻia mai ka mimi me ka prototype a me nā metabolites.Hoʻohana ʻia ia no ka mālama ʻana i ka rheumatic a me ka rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout, arthritis, tenosynovitis.Akā, e hoʻomanaʻo ʻia e like me nā lāʻau anti-inflammatory non-steroidal, hiki ke loaʻa nā hopena koʻikoʻi koʻikoʻi o ka ʻōpū i kēlā me kēia manawa i ka wā e lawe ana i ka naproxen i ka wā o ka mālama ʻana, no laila ua kau ʻia nā mea maʻi maʻi maʻi maʻi gastroduodenal, pono nā mea maʻi ʻē aʻe e lawe i kēia. lāʻau lapaʻau ma lalo o ke kiaʻi kino.Hoʻopili ʻia ʻo Naproxen mai ka 2-methoxynaphthalene a me ka (+)-isomer i loaʻa ma ka hoʻonā me cinchonidine (61).Ua hoʻokomo ʻia ia ma ʻAmelika Hui Pū ʻIa i ka makahiki 1976 a, ma ke ʻano he lāʻau lapaʻau maʻamau, ua mau i waena o nā NSAID kaulana loa.Kūʻai ʻia ʻo ia ma ke ʻano he S-(+)-enantiomer, akā ʻo ka mea hoihoi, aia ka paʻakai sodium o ka (-)-isomer ma ka mākeke e like me Anaprox.Ma ke ʻano he mea paʻa i ka biosynthesis prostaglandin, he 12 manawa ʻoi aku ka ikaika ma mua o ka aspirin, 10 mau manawa ʻoi aku ka ikaika ma mua o ka phenylbutazone, ʻekolu a ʻehā mau manawa ʻoi aku ka ikaika ma mua o ka ibuprofen, a ʻehā mau manawa ʻoi aku ka ikaika ma mua o ka fenoprofen, akā he 300 mau manawa ʻoi aku ka ikaika ma mua o ka fenoprofen. indomethacin.