Olopatadine Hydrochloride Intermediate CAS 27710-82-3 Maʻemaʻe >99.0% (HPLC)
Mea hoʻolako alakaʻi o Olopatadine Hydrochloride Intermediates
Olopatadine Hydrochloride CAS 140462-76-6
Isoxepac CAS 55453-87-7
[3-(Dimethylamino)propyl]triphenylphosphonium Bromide Hydrobromide CAS 27710-82-3
Please Contact: alvin@ruifuchem.com
| Inoa Kimia | [3-(Dimethylamino)propyl]triphenylphosphonium Bromide Hydrobromide |
| Nā huaʻōlelo like | (3-Dimethylaminopropyl)triphenylphosphonium Bromide HBr |
| Helu CAS | 27710-82-3 |
| Helu CAT | RF2698 |
| Kūlana Kūʻai | Ma ka waihona, hoʻonui ʻia a hiki i nā tona |
| ʻĀpana Molekala | C23H28Br2NP |
| Kaumaha Molecular | 509.27 |
| Lae hehee | 283.0~285.0 ℃ |
| Paʻa | Hygroscopic |
| Ka hikiwawe | Chloroform (Liʻiliʻi), Methanol (Liʻiliʻi) |
| Brand | Kemika Ruifu |
| 'ikamu | Nā kikoʻī |
| Ka nana aku | Keʻokeʻo a i ka pauka kristal keʻokeʻo |
| Maʻemaʻe / Kaʻina Hanana | >99.0% (HPLC) |
| Hana ʻIke / ʻIke | >99.0% (Titration) |
| Nalo ma ka maloo | <0.50% |
| Hoʻokahi haumia | <0.50% |
| Huina paumaele | <1.00% |
| 1 H NMR Spectrum | Kūlike me ka hoʻolālā |
| Kūlana hoʻāʻo | Kūlana ʻoihana |
| Hoʻohana | Waena o Olopatadine Hydrochloride (CAS: 140462-76-6) |
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[3-(Dimethylamino)propyl]triphenylphosphonium Bromide Hydrobromide (CAS: 27710-82-3) he mea waena o Olopatadine Hydrochloride (CAS: 140462-76-6).ʻO ka Olopatadine Hydrochloride kahi lāʻau anti-allergic.Loaʻa iā ia nā hopena ʻelua o ke kāohi ʻana i ka hoʻokuʻu ʻana o ka histamine a me ke koho ʻana i nā mea hoʻokipa HI, a ʻaʻohe mea hoʻopaʻapaʻa ʻōnaehana kikowaena a me nā hopena ʻawaʻawa o ka naʻau i maʻa mau me HI receptor antagonist antiallergic lāʻau.ʻAʻole hiki i ka Olopatadine Hydrochloride ke kāohi wale i ka hoʻokuʻu ʻana o ka histamine mai nā mast cell, akā ke hoʻohālikelike nei i nā mea hoʻokipa H1 me ka koho ʻole, a ʻaʻohe hopena i ka α adrenergic receptors, dopamine receptors, a me M1 a me M2 receptors.I waena o lākou, he liʻiliʻi nā hopena ʻaoʻao o ke kikowaena kikowaena, he hanauna hou o nā lāʻau antiallergic koho.ʻO Olopatadine kahi mea kū'ē ikaika a koho i ka H1 histamine receptor (Ki = 16-41.1 nM), me ka haʻahaʻa haʻahaʻa loa no ka H2 a me H3 receptors (Ki = 43.4 a me 172 μM, kēlā me kēia).Hoʻopaʻa ia i ka huli ʻana o ka phosphoinositide i hoʻokomo ʻia i ka histamine i loko o nā keʻena kaʻawale (IC50 = 9.5-39.9 nM) a pale i ka anaphylaxis cutaneous passive i nā ʻiole (ED50 = 49 μg/kg) a me ka bronchoconstriction anaphylactic i nā puaʻa guinea (ID50 = 30 μg/kg).He mea maikaʻi ʻo Olopatadine i ka mālama ʻana i ka maʻi rhinitis a me ka conjunctivitis.Hoʻopau pū ia i ka ʻili i nā poʻe maʻi me ka urticaria maʻi i hoʻomalu maikaʻi ʻia.I loko o ke kanaka, ʻaʻole hiki i kēia antihistamine ke hōʻeha i ka cognitive a i ʻole psychomotor impairment ma nā lāʻau lapaʻau.
