Palonosetron Hydrochloride CAS 135729-62-3 Maʻemaʻe >99.0% (HPLC) (T) Hale Hana API
Hāʻawi Kalepa ʻo Palonosetron Hydrochloride a me nā mea e pili ana i waena:
(S)-1,2,3,4-Tetrahydro-1-Naphthoic Acid CAS: 85977-52-2
(R)-1,2,3,4-Tetrahedro-1-Naphthoic Acid CAS: 23357-47-3
(S)-3-Aminoquinuclidine Dihydrochloride CAS: 119904-90-4
3-Quinuclidinone Hydrochloride CAS: 1193-65-3
1-Naphthoic Acid CAS: 86-55-5
Palonosetron Hydrochloride CAS: 135729-62-3 API
Inoa Kimia | Palonosetron Hydrochloride |
Nā huaʻōlelo like | Palonosetron HCl;(S,S)-Palonosetron Hydrochloride;RS-25259;RS25259 197;(S)-2-((S)-Quinuclidin-3-yl)-2,3,3a,4,5,6-Hexahydro-1H-Benzo[de]isoquinolin-1-one Hydrochloride;(3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-Hexahydro-1H-benz[de]isoquinolin-1-one Hydrochloride ;Aloxi;Onicit |
Helu CAS | 135729-62-3 |
Helu CAT | RF-API03 |
Kūlana Kūʻai | Ma ka waihona, hoʻonui ʻia a hiki i nā tona |
ʻĀpana Molekala | C19H24N2O·HCl |
Kaumaha Molecular | 332.87 |
Kūlana e hōʻalo ai | Paʻa wela |
Lae hehee | 307℃ (Dek.) |
Solubility i ka wai | Paʻa loa i ka wai |
Ka hikiwawe | Hiki ke hoʻoheheʻe ʻia i loko o ka Ethanol |
Ka Mahana Hoouna | ʻO ka Mahana Kūlohelohe |
COA & MSDS | Loaʻa |
Brand | Kemika Ruifu |
'ikamu | Nā kikoʻī |
Ka nana aku | Keʻokeʻo a i ʻole ke keʻokeʻo Crystalline pauda |
Palonosetron Hydrochloride | >99.0% (HPLC) (T) |
Ka Po'ai Pono [α]20/D | -98.0°~-104.0° |
ʻIkepili | Hoʻohui i ka BiI7K4,Hana i ka ʻAlani Melemele Precipitate |
ʻIkepili | Kūlike ʻo TLC me ka mea kuhikuhi |
ʻIkepili | IR Kūlike me ka IR maʻamau |
ʻIkepili | ʻIke ʻia ʻo Chloride |
Ka hikiwawe | Hiki ke hoʻoheheʻe ʻia i ka wai, hiki ke hoʻoheheʻe ʻia i ka Methanol, hiki ke hoʻoheheʻe ʻia i ka ethanol, hiki ʻole ke hoʻoheheʻe ʻia i ka acetone. |
Maopopo a me ke kala o ka hoʻonā | Max.Melemele No |
pH Vaule | 4.5~6.5 (10mg/ml) |
Na Mea Pili | |
Huihui A (NO) pili | <0.10% |
Puʻupuʻu pili B (Ene-NO) | <0.10% |
Huihui C (S,R) pili | <0.10% |
Huihui D (R,S) pili | <0.50% |
Palonosetron Enantiomer | <0.10% |
Huina E pili ana (3-Ene) | <0.50% |
Hoʻokahi ʻano haumia ʻole | <0.10% |
Nā mea hoʻoheheʻe koena | |
Ethanol | <3000ppm |
Tetrahydrofuran | <5000ppm |
DMF | <880ppm |
Hexane maʻamau | <290ppm |
Methyl Alcohol | <3000ppm |
Isopropanol | <5000ppm |
Methylbenzene | <890ppm |
Wai | <0.30% |
Koena ma ka Ignition | <0.20% |
Nalo ma ka maloo | <1.00% |
Nā Metala Kaumaha | <10ppm |
Kūlana hoʻāʻo | ʻAmelika Hui Pū ʻIa Pharmacopoeia (USP);ʻEulopa Pharmacopoeia (EP) |
Hoʻohana | Palonosetron Hydrochloride API;5-HT3 mea kū'ē;CINV |
Pūʻolo: ʻO ka ʻōmole, pahu pahu pahu, 25kg/drum, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Waihona:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;Palekana mai ka malamalama, ka ma'ū a me ka pest infestation.
ʻO Palonosetron Hydrochloride (CAS: 135729-62-3) he lāʻau lapaʻau e pale ai i ka nausea a me ka luaʻi ʻana, he ʻano hou i koho nui ʻia, kiʻekiʻe-affinity 5-HT3 receptor antagonist hiki ke pale i ka luaʻi reflex center peripheral neurons presynaptic 5-HT.Hoʻopili pololei ka hauʻoli o ka mea hoʻokipa i ka ʻōnaehana kikowaena waena ma 5-HT.Hoʻoulu ʻia ka hauʻoli o ka mea loaʻa i ka vagal afferent ma hope o ka wahi, ke kāohi ʻana i nā hopena nerve vagus i loko o ka ʻōpū, e pale ana i nā hōʻailona i 5-HT.Hiki i ka Receptor trigger zone ke hoemi i ka nui o ka nausea a me ka luai.ʻO ke kikowaena kikowaena no ka mālama ʻana i ka chemotherapy emetogenic koʻikoʻi i hoʻoulu ʻia i ka nausea a me ka luaʻi ʻana.Ma muli o kona hopena curative kiʻekiʻe, hopena ʻaoʻao liʻiliʻi, lōʻihi ka hapalua o ke ola (e pili ana i 40 h), liʻiliʻi liʻiliʻi, a pēlā aku, ua huki nui ia.
Me ka 1,2,3,4-Tetrahydro-1-Naphthoic Acid e like me ka mea hoʻomaka, ka māhele, amination, hōʻemi, cyclization, paʻakai o ka palonosetron hydrochloride granisetron.Ua hōʻike ʻia nā haʻawina lāʻau lapaʻau e hiki ke hoʻohana palekana ʻia ka palonosetron me nā corticosteroids, analgesics, antiemetics, antispasmodics a me nā lāʻau anticholinergic e like me ka mea hoʻomaka, ka māhele, amination, hōʻemi, cyclization, paʻakai o ka palonosetron hydrochloride granisetron.