Polymyxin B Sulfate CAS 1405-20-5 Assay Microbiological ≥6500 IU/mg Factory
ʻO Shanghai Ruifu Chemical Co., Ltd. ka mea hana nui a me ka mea hoʻolako o Polymyxin B Sulfate (CAS: 1405-20-5) me ke kūlana kiʻekiʻe.Hiki iā mākou ke hāʻawi i ka COA, ka lawe ʻana i ka honua holoʻokoʻa, nā mea liʻiliʻi a me ka nui i loaʻa.Inā makemake ʻoe i ka Polymyxin B Sulfate,Please contact: alvin@ruifuchem.com
| Inoa Kimia | Polymyxin B Sulfate |
| Nā huaʻōlelo like | Polymyxin B Sulfate Paakai;Aerosporin;Mastimyxin;PXNS;PMB;Poly-RX |
| Kūlana Kūʻai | I loko o ka waihona, hana hiki ke 10 tona no ka makahiki |
| Helu CAS | 1405-20-5 |
| ʻĀpana Molekala | C55H96N16O13·2H2SO4 |
| Kaumaha Molecular | 1301.56 |
| Lae hehee | 217.0~220.0℃(Dek.) |
| Pilikino | Hygroscopic.Paʻa i ka Māmā a me ka Wela |
| Hiki i ka wai | Hiki i ka wai, 50 mg/mL.Hiki ke hoʻoheheʻe ʻia i loko o ka Ethanol |
| COA & MSDS | Loaʻa |
| Laʻana | Loaʻa |
| Brand | Kemika Ruifu |
| Nā mea | Nā kikoʻī | Nā hualoaʻa |
| Ka nana aku | Keʻokeʻo a ʻaneʻane Me ka pauda Crystalline | Kūlike |
| ʻIkepili A. ʻO nā manawa paʻa o nā piko nui mai ka hāpana hāpana e pili ana i ko ka hopena maʻamau, e like me ka loaʻa ʻana ma ka hoʻāʻo no ka haku ʻana o Polymyxins. | Kūlike | |
| PH (2%) | 5.0-7.0 | 5.7 |
| PH (0.5%) | 5.0-7.5 | 5.5 |
| Lehu Sulphated | ≤0.75% |
|
| Ka Po'ai Pono [α]20/D | -78.0°~-90.0°(C=2, H2O) (Ka helu ʻana ma Anh. Substance) | -85.0° |
| Sulphate | 15.5-17.5% | 16.65% |
| Nalo ma ka maloo | ≤6.00% | 3.0% |
| Koena ma ka Ignition | ≤0.10% | 0.02% |
| Nā Metala Kaumaha | ≤20ppm | ≤20ppm |
| Phenylalanine | 9.0-12.0% | 9.8% |
| Huina Viabel Aerobic | ≤10cfu/g | ≤10cfu/g |
| Nā mea pili, HPLC |
|
|
| Ka haumia o ke kanaka | ≤3.0% | 2.723% |
| Huina paumaele | ≤17.0% | 16.223% |
| Hōʻike HPLC (ODB) | Huina o Polymyxins B1,B2,B3 a me B1-1: ≥80.0% | 86.6% |
| Polymyxin B3: ≤ 6.0% | 3.8% | |
| Polymyxin B1-1: ≤15.0% | 8.5% | |
| ʻIke, Microbiological (e like me ia) | ≥6500lU/mg | 8255IU/mg |
| Ka nui o ka ʻāpana | ≥99.0% ≤30um e vol | Kūlike |
| ≥90.0% ≤25um e vol | ||
| ≥75.0%≤20um e vol | ||
| ≥35.0%≤10um e vol | ||
| Ka hopena | Hoʻopili ka huahana i ka USP42 |
|
Pūʻolo:ʻO ka ʻōmole, ʻeke ʻeke alumini, 25kg / pahu pahu pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:Māmā māmā.E hoʻopaʻa paʻa i ka pahu a mālama i loko o kahi hale kūʻai maloʻo a maloʻo (2 ~ 8 ℃) a me kahi hale kūʻai maikaʻi mai nā mea like ʻole.E pale i ka malamalama a me ka wai.ʻAʻole kūpono me nā mea oxidizing ikaika.
Hoʻouna:Hāʻawi i ka honua ma ka lewa, e FedEx / DHL Express.Hāʻawi wikiwiki a hilinaʻi hoʻi.
Pehea e kūʻai ai?E ʻoluʻolu e kelepona maiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 mau makahiki ʻike?Loaʻa iā mākou ma mua o 15 mau makahiki o ka ʻike i ka hana ʻana a me ka hoʻokuʻu ʻana aku i kahi ākea ākea o nā intermediates pharmaceutical kiʻekiʻe a i ʻole nā kemika maikaʻi.
Mākeke Nui?E kūʻai aku i ka mākeke kūloko, ʻAmelika ʻĀkau, ʻEulopa, India, Korea, Iapana, Australia, etc.
Nā pono?ʻO ke kūlana kiʻekiʻe, ke kumukūʻai kūpono, nā lawelawe ʻoihana a me ke kākoʻo ʻenehana, ka lawe wikiwiki ʻana.
ʻAno maikaʻiHōʻoiaʻiʻo?Pūnaehana hoʻomalu maikaʻi koʻikoʻi.ʻO nā lako ʻoihana no ka nānā ʻana ʻo NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Nā laʻana?Hāʻawi ka hapa nui o nā huahana i nā laʻana manuahi no ka loiloi maikaʻi, pono e uku ʻia ke kumukūʻai e nā mea kūʻai aku.
Hooia Hale Hana?Welina mai ka loiloi hale hana.E ʻoluʻolu e hoʻopaʻa manawa ma mua.
MOQ?ʻAʻohe MOQ.ʻAe ʻia ke kauoha liʻiliʻi.
Manawa Hoʻouna? Inā i loko o ka waihona, ʻekolu lā hoʻouna ʻia.
Kaʻahele?Ma ka Express (FedEx, DHL), ma ka Air, ma ke Kai.
Nā palapala?Ma hope o ka lawelawe kūʻai: COA, MOA, ROS, MSDS, etc.
Hoʻohui Kuʻuna?Hiki ke hāʻawi i nā lawelawe synthesis maʻamau e kūpono i kāu mau pono noiʻi.
Kūkākūkā uku?E hoʻouna mua ʻia ka invoice Proforma ma hope o ka hōʻoia ʻana o ke kauoha, hoʻopili ʻia kā mākou ʻike panakō.Uku e T/T (Telex Transfer), PayPal, Western Union, etc.
Nā hōʻailona pōʻino Xn - ʻino
Nā Code Risk 22 - He pōʻino ke ʻai ʻia
Hōʻike Palekana S22 - Mai hanu i ka lepo.
S24/25 - Hōʻalo i ka pili ʻana me ka ʻili a me nā maka.
UN ID 3249
WGK Kelemānia 3
RTECS TR1150000
FLUKA BRAND F CODES 3-8-10
HS Code 2941909099
Papa Hazard 6.1(b)
Hui Pūʻulu III
ʻO Polymyxin kahi hui o nā lāʻau antibiotic polypeptide i hana ʻia e Bacillus polymyxa (bacilluspolymyxa).Hoʻohana ʻia ka Polymyxin B a me E no nā lāʻau lapaʻau, a hoʻohana mau ʻia kā lākou sulfate.ʻO keʻano antibacterial spectrum a me ka noi lapaʻau o Polymyxin B Sulfate ua like ia me nā polymyxin E. Loaʻa iā ia nā hopena inhibitory a iʻole bactericidal i ka bacilli gram-negative, e like me Escherichia coli, Pseudomonas aeruginosa, paracilli, Klebsiella pneumoniae, acidophilus, pertussis a me Shigella.
Ua like ka Polymyxin Sulfate B me ka polymyxin e, a loaʻa iā ia nā hopena pale a i ʻole nā bactericidal i ka bacilli gram-negative, e like me ka e.coli, pseudomonas aeruginosa, paracilli, Klebsiella pneumoniae, acidophilus, bacilli pertussis a me dysentery bacilli.Hoʻohana nui ʻia ia i ka ʻeha, urinary tract, maka, pepeiao, trachea a me nā ʻāpana ʻē aʻe o ka maʻi i hana ʻia e Pseudomonas aeruginosa a me nā Pseudomonas ʻē aʻe.Hiki ke hoʻohana ʻia no ka sepsis a me ka peritonitis.A me nā maʻi koʻikoʻi i hoʻokumu ʻia e nā aminoglycosides, ke kolu o ka hanauna cephalosporin-resistant bacteria, Pseudomonas aeruginosa a i ʻole nā mea maʻi ʻē aʻe, e like me ka bacteremia, endocarditis, pneumonia, post-burn infection, etc.
1. Intravenous drip: nā mākua a me nā keiki me ka hana renal maʻamau 1.5 ~ 2.5mg no ka kilo o ke kaumaha o ke kino (maʻamauʻaʻoleʻoi aku ma mua o 2.5mg no kilokani o ke kaumaha o ke kino) no ka lā 1, māheleʻia i 2 manawa, hoʻokahi manawa i kēlā me kēia 12 hola.ʻO kēlā me kēia 50mg o kēia huahana e hoʻoheheʻe ʻia me 500ml o 5% glucose solution a laila kulu.Hiki i nā pēpē me ka hana renal maʻamau ke ʻae i ka 4mg no ka kilokani o ke kaumaha o ke kino no 1 lā.2. Intramuscular injection: nā mākua a me nā keiki: 2.5 ~ 3mg no ka kilo o ke kaumaha o ke kino ma ka 1st, hāʻawiʻia i nā hui, hoʻokahi manawa i kēlā me kēia 4 ~ 6 hola.Hiki i nā kamaliʻi ke hiki i ka 4mg no ke kilokani o ke kaumaha o ke kino i kēlā lā i kēia lā a hiki i nā keiki hānau hou ke hiki i ka 4.5mg no ke kilokika o ke kaumaha o ke kino.3. Intrathecal injection (no Pseudomonas aeruginosa maningitis): 5mg no ka milliliter o ka lāʻau lapaʻau wai i hoʻomākaukau ʻia me ka inikini sodium chloride.ʻO nā mākua a me nā keiki ma mua o 2 mau makahiki, 5mg i kēlā me kēia lā, ma hope o 3-4 mau lā o ka noi, hoʻololi i hoʻokahi manawa i kēlā me kēia lā, ma ka liʻiliʻi 2 pule, a hiki i ka maikaʻi ʻole o ka moʻomeheu cerebrospinal fluid, a maʻamau ka maʻi kō.No nā keiki ma lalo o 2 mau makahiki, e hoʻohana i ka 2mg hoʻokahi i ka lā no 3-4 mau lā (a i ʻole 2.5mg hoʻokahi i kēlā me kēia lā), a laila hoʻohana i ka 2.5mg hoʻokahi i kēlā me kēia lā a hiki i ka hoʻāʻo ʻana.4. ʻO ka manaʻo o nā hāʻule o ka maka he 1 ~ 2.5mg i ka ml.
E hōʻole i ka hui pū ʻana me nā lāʻau e hōʻino ai i nā puʻupaʻa, nā mea hoʻomaha ʻiʻo iwi, nā lāʻau antibiotic aminoglycoside, nā anesthetics me nā hopena hoʻomaha hoʻomaha ʻiʻo (e like me enflurane), etc., a me ka quinine, magnesium, etc. ʻaʻole hiki ke hoʻohana i ka intravenously i ka manawa like.Hoʻohui ʻia ʻo Polymyxin B sulfate me nā sulfonamides, rifampicin, semi-synthetic penicillin, a me nā mea ʻē aʻe, no ka mālama ʻana i nā maʻi bacterial gram-negative kūʻē i ka lāʻau, a ʻoi aku ka maikaʻi o ka hopena ma mua o ka noi hoʻokahi.
1, ʻO nā wahine hāpai a me ka lactating, nā keiki, a me nā mea maʻi me ka lawa ʻole o ka renal ka mea maʻamau.2. He mea ʻawaʻawa kēia huahana a he hopena maikaʻi ʻole kona hopena i ka maʻi ʻiʻo hohonu.ʻAʻole ia ka koho mua no kekahi maʻi.3. ʻO ka hoʻokomo ʻana i loko o ke koko ke hoʻoulu i ke kaumaha o ka hanu, ʻaʻole i hoʻohana mau ʻia.ʻO ka hapa liʻiliʻi o ka nui o kēlā me kēia lā e pono ai ka hoʻoheheʻe intravenous, ʻaʻole ka bolus wikiwiki i ka manawa hoʻokahi, i pale aku ai i ka poloka neuromuscular nui.4. ʻAʻole pono e hui pū ʻia me nā lāʻau ʻē aʻe me ka nephrotoxicity a i ʻole neuromuscular blockade e pale aku i nā pōʻino.
Ka noiʻi biochemical.ʻO ka Polymyxin B kahi anti-gram-negative bacilli polypeptide antibiotic, hiki ke hoʻololi i ke ʻano o ka membrane e hoʻokuʻu i nā mole liʻiliʻi a keʻakeʻa i ka ulu ʻana o nā hua bacteria gram-negative.He hopena bactericidal kona ma Escherichia coli.Lipid A i hoʻopaʻa ʻia i nā lipopolysaccharides bacteria.Hoʻokomo ʻia nā pores liʻiliʻi i loko o ka membrane cell ʻili o waho.Ke ʻano o ka hana: hoʻopaʻa a hoʻopilikia i ka permeability o ka membrane cytoplasmic.ʻĀpana antibacterial: Gram-negative bacteria.
Polymyxin B, Sulfate.
Polymyxin B Sulfate [1405-20-5].
» ʻO Polymyxin B Sulfate ka paʻakai sulfate o kekahi ʻano polymyxin, he mea i hana ʻia e ka ulu ʻana o Bacillus polymyxa (Prazmowski) Migula (Fam. Bacillaceae), a i ʻole ka hui ʻana o nā paʻakai ʻelua a ʻoi aku paha.Loaʻa ka mana o ka liʻiliʻi ma mua o 6000 Polymyxin B Units i ka mg, helu ʻia ma ke kumu maloʻo.
Hoʻopili ʻia a mālama ʻia - mālama ʻia i loko o nā pahu paʻa māmā.
Lepili-Ma kahi i hoʻopaʻa ʻia no ka hoʻohui ʻana i ka lāʻau lapaʻau, hōʻike ka lepili i ka helu o nā ʻāpana Polymyxin B i loko o ka pahu a me ka milligram, ʻaʻole ia i manaʻo ʻia no ka hoʻohana ʻana i ka hana, ʻaʻole sterile, a ʻaʻole hiki ke hōʻoia i kona ikaika no ka lōʻihi o 60 mau lā ma hope o ka wehe ʻana.Ma kahi i manaʻo ʻia e hoʻohana i ka hoʻomākaukau ʻana i ka injectable a i ʻole nā mea hoʻohana sterile ʻē aʻe, ʻōlelo ka lepili he sterile a pono e hoʻokō ʻia i ka hana hou ʻana i ka wā o ka hoʻomākaukau ʻana i nā ʻano mea hoʻohana injectable a i ʻole.
Nā kūlana hōʻike USP <11>-
USP Polymyxin B Sulfate RS
ʻike-
A: Liquid Chromatographic Identification Test-
ʻĀpana Mobile-E hoʻomākaukau i ka hui ʻana o 0.1 M tribasic sodium phosphate a me acetonitrile (77:23), a hoʻoponopono me ka phosphoric acid i kahi pH o 3.0.Hana i nā hoʻololi inā pono (e nānā i ka System Suitability ma lalo o Chromatography <621>.
Haʻina maʻamau-E hoʻomākaukau i ka hoʻonā o USP Polymyxin B Sulfate RS ma ka māhele Mobile me ka manaʻo ma kahi o 3.5 mg no ka mL.E pale i kēia hoʻonā mai ka mālamalama.
Hoʻonā hoʻāʻo-E hoʻomākaukau i ka hopena o ka Polymyxin B Sulfate i loko o ka pae Mobile nona ka ʻike ma kahi o 3.5 mg no ka mL.E pale i kēia hoʻonā mai ka mālamalama.
Pūnaehana Chromatographic (e nānā i ka Chromatography <621>)-Ua hoʻolako ʻia ka chromatograph wai me kahi mea ʻike 212-nm a me kahi kolamu 4.6-mm × 25-cm i loaʻa iā 5-µm packing L1.ʻO ka nui o ke kahe e pili ana i 1 mL i kēlā me kēia minuke.
Ke Kaʻina Hana - Hoʻokaʻawale i nā puke like (ma kahi o 10 µL) o ka solution Standard a me ka solution Test i loko o ka chromatograph, a hoʻopaʻa i nā chromatograms.ʻO ka chromatogram i loaʻa mai ka hoʻonā hoʻāʻo e pili ana i ka mea i loaʻa mai ka solution Standard, e hōʻike ana i kahi piko nui e pili ana i ka polymyxin B1 a me nā piko i nā manawa paʻa pili ma kahi o 0.5 (polymyxin B2) a me 0.6 (polymyxin B3).
B: E hoʻoheheʻe i 2 mg i 5 mL o ka wai, e hoʻohui i 5 mL o 2.5 N sodium hydroxide, hui, a hoʻohui i 5 kulu o ka solution cupric sulfate (1 i ka 100), e haʻalulu ana ma hope o ka hoʻohui ʻana o kēlā me kēia hāʻule: hana ʻia kahi waihoʻoluʻu ʻulaʻula. .
C: Hoʻokō ka hopena (1 i ka 20) i nā koi o nā hoʻokolohua no Sulfate <191>.
pH <791>: ma waena o 5.0 a me 7.5, i loko o kahi hopena i loaʻa ka 5 mg no ka mL.
Nalo ma ka maloo <731>-Moloolo ma kahi o 100 mg, i kaupaona pono, i loko o ka pahu capillary-stoppered i loko o ka vacuum ma 60 ℃ no 3 hola: ʻaʻole e nalowale ma mua o 7.0% o kona kaumaha.
ʻO ka maʻiʻo o ka phenylalanine-Transfer e pili ana i 0.375 g o Polymyxin B Sulfate, i kaupaona pono ʻia, i kahi pahu volumetric 100-mL, hoʻoheheʻe i loko a hoʻoheheʻe me 0.1 N hydrochloric acid i ka nui, a hui.E ana i ka absorbances o keia solution ma ka maxima ma kahi o 264 nm (A264), 258 nm (A258), a me 252 nm (A252), a me na absorbances ma 280 nm (A280) a me 300 nm (A300).E helu i ka pākēneka o ka phenylalanine i loko o ka māhele o Polymyxin B Sulfate i lawe ʻia e ke kumu:
(9.4787/W)(A258 – 0.5A252 + 0.5A264 – 1.84A280 + 0.8A300)
ʻo W ka paona, ma g, o Polymyxin B Sulfate i lawe ʻia: aia ma waena o 9% a me 12% o ka phenylalanine, i helu ʻia ma ke kumu maloʻo.
Nā koi ʻē aʻe- Inā no ka hoʻohui ʻana i ka lāʻau lapaʻau, hoʻokō ʻo ia i nā koi no ke koena ma ka ʻā ʻana ma lalo o Polymyxin B no ka Injection.Ma kahi e ʻōlelo ai ka lepili he sterile ka Polymyxin B Sulfate, ua kūpono ia i nā koi no nā ho'āʻo Sterility <71> a, ma kahi i manaʻo ʻia no nā ʻano hana injectable, no Pyrogen ma lalo o Polymyxin B no ka Injection.Ma kahi e ʻōlelo ai ka lepili e pono e hoʻokō ʻia ka Polymyxin B Sulfate i ka wā o ka hoʻomākaukau ʻana i nā ʻano ʻano injectable, e hoʻokō ia i nā koi no Pyrogen ma lalo o Polymyxin B no ka Injection.
E hoʻomau me ka Polymyxin B Sulfate e like me ke kuhikuhi ʻana ma lalo o Antibiotics-Microbial Assays <81>.
