Posaconazole CAS 171228-49-2 API Factory Triazole Antifungal Agent Kiʻekiʻe
Hale Hana Hoʻolako Posaconazole Pili ana i waena, hana kalepa
Posaconazole CAS 171228-49-2
Posaconazole Intermediate POA CAS 149809-43-8
Phenyl (4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)carbamate CAS 184177-81-9
1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine CAS 74853-08-0
2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxal CAS 170985-85-0
Diethyl L-(+)-Tartrate CAS 87-91-2
Inoa Kimia | ʻO Posaconazole |
Nā huaʻōlelo like | POS;SCH 56592;4-[4-[4-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl] methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one |
Helu CAS | 171228-49-2 |
Helu CAT | RF-API77 |
Kūlana Kūʻai | Ma ka waihona, ʻoi aku ka nui o ka hana a hiki i nā haneli kilogram |
ʻĀpana Molekala | C37H42F2N8O4 |
Kaumaha Molecular | 700.78 |
ʻO ka mānoanoa | 1.36 g/cm3 |
Ka hikiwawe | Hiki ke hoʻoheheʻe ʻia i DMSO, ʻaʻole hiki ke hoʻoheheʻe ʻia i ka wai |
Kūlana Hoʻouna | Hoʻouna ʻia ma lalo o ka wela ambient |
Brand | Kemika Ruifu |
'ikamu | Nā kikoʻī |
Ka nana aku | Keʻokeʻo a i ka pauka kristal keʻokeʻo |
ʻIkepili A | IR: Pono e kūlike ka spectrum absorption infrared o ka huahana me ko ka mea kuhikuhi |
ʻIkepili B | ʻO ka manawa paʻa HPLC e like me ka mea kuhikuhi |
Lae hehee | 167.0~171.0 ℃ |
Ka Poali Pono [a]20 | -24.0° ~ -28.0° (C=1, CHCL3) |
Wai (KF) | ≤1.0% |
Koena ma ka Ignition | ≤0.10% |
Na mea pili | |
HT 909-24 | ≤0.20% |
ʻO kēlā me kēia haumia kanaka | ≤0.10% |
Huina paumaele | ≤1.0% |
Nā mea hoʻoheheʻe koena | |
Methanol | ≤3000ppm |
Methyl tert-Butyl Etera | ≤5000ppm |
Isopropanol | ≤5000ppm |
Dimethyl Sulfoxide | ≤5000ppm |
Dichloromethane | ≤600ppm |
Hoʻāʻo | 98.0%~102.0% (I helu ʻia ma ke kumu maloʻo) |
Nā Metala Kaumaha | ≤10ppm |
Isomer | Enantiomer ≤0.10% |
ʻO kēlā me kēia kanaka haumia ≤0.10% | |
Huina haumia ≤1.0% | |
Kūlana hoʻāʻo | ʻOihana Kūlana;USP;BP;EP Kūlana |
Hoʻohana | API, Triazole Antifungal Agent |
Pūʻolo: ʻO ka ʻōmole, ʻeke ʻeke alumini, pahu pahu pahu, 25kg / pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;Palekana mai ka malamalama, ka ma'ū a me ka pest infestation.
ʻO Posaconazole (CAS 171228-49-2), he laulā ākea, lua o ka hanauna, triazole pūhui me ka hana antifungal, i hoʻokuʻu ʻia ma UK, ʻo ia ka lālā hou o ka papa azole o nā mea antifungal a hiki i ka mākeke.Hōʻike ʻia ia no ka mālama ʻana a me ka prophylaxis o kahi ʻano o nā maʻi fungal invasive, me ka aspergillosis, fusariosis, chromoblastomycosis, mycetoma, a me ka coccidiomycosis i nā poʻe maʻi e kūpaʻa ʻole, a intolerant paha i ka lāʻau maʻamau me amphotericin B a / a itraconazole.Ma US, ua ʻae ʻia ia no ka prophylaxis o nā maʻi invasive Aspergillus a me Candida i nā maʻi 13 mau makahiki i ka nui o ka pilikia o ka hoʻomohala ʻana i kēia mau maʻi ma muli o ka loaʻa ʻana o ka immunocompromised.Eia kekahi, ua ʻae ʻia no ka mālama ʻana i ka candidiasis oropharyngeal.Loaʻa i ka Posaconazole kahi kikoʻī o ka hana ma luna o nā lālā ʻē aʻe o ka azole antifungals.Ma kahi o ka hana ikaika e kū'ē i nā hihia refractory o ka aspergillosis a me ka fluconazole-resistant Candida, hōʻike ia i ka hana kūʻē iā Zygomycetes.ʻO Posaconazole kahi lāʻau antifungal triazole i kūʻai ʻia ma United States e Schering-Plough ma lalo o ka inoa kālepa Noxafil.