PyBrOP CAS 132705-51-2 Maʻemaʻe >99.0% (HPLC) Nā Mea Hoʻohui Hale Hana

ʻO ka Bromotripyrrolidinophosphonium Hexafluorophosphate (PyBrOP) (CAS: 132705-51-2) he mea hoʻopaʻa paʻa no ka hui ʻana o nā waikawa N-Methylamino i ka peptide synthesis.Hoʻohana ʻia no ka synthesis o depsipeptides.
ʻO PyBroP kahi peptide coupling reagent i hoʻohana ʻia i ka synthesis o ka rostate tumor specific peptide-peptoid hybrid prodrugs.He mea hoʻopili peptide reactive kūpono no nā waikawa amino α,α-dialkyl.
Ka mea hoʻoheheʻe no: ka hoʻohui ʻana o nā amides mua, hoʻopili pololei i ka phosphonium dehydrative cross, arylation pololei, hana pyrrolidide e nā mea hoʻohui paʻakai phosphonium.
ʻO PyBroP kahi paʻakai phosphonium i hoʻohana ʻia i ka peptide coupling chemistry, e like me PyCloP.Hōʻike ʻo PyBroP i ka maikaʻi kiʻekiʻe i ka hui ʻana o nā waikawa amino N-methylated a me nā waikawa amino α, α-disubstituted, me nā hua maikaʻi loa, ʻaʻohe epimerization a me ka wikiwiki wikiwiki.He paʻa paʻa ʻo PyBroP hiki ke hoʻohana ʻia i loko o kahi kaʻina hana hoʻokahi-pota a hiki ke hoʻoheheʻe ʻia i loko o nā solvents i hoʻohana mau ʻia no ka peptide coupling chemistry.ʻO ka PyBroP kahi huaʻōlelo o ka phosphonium coupling reagent BOP akā aia kahi moiety pyrrolidine ma kahi o ka dimethylamine o BOP.ʻO ka pahuhopu ma hope o ka hoʻolālā ʻana o PyBroP ʻo ia ka pale ʻana i ka hoʻokumu ʻia ʻana o ka HMPA ʻona a me ka carcinogenic by-product i hana ʻia me BOP, akā me nā hana like.
Hiki ke hoʻohana ʻia ʻo PyBroP ma ke ʻano he reagent hoʻohui: No Suzuki-Miyaura hui kea o nā phenols a me nā waikawa arylboronic e synthesize i nā biaryls a me nā heterobiaryls.E hoʻohana i nā pyrimidines (synthesized mai 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) ma o ka Kappe dehydrogenation) ma o ka hoʻohana ʻana i nā nucleophiles like ʻole.No ka hoʻohui ʻana i nā formamidines ma o ka hoʻohui ʻana me nā amine kumu like ʻole a me N,N-diisopropylethylamine.Hiki ke hoʻohana ʻia ma ke ʻano he mea hoʻoulu: No ka hoʻāla ʻana o ka paʻa C-OH i nā heterocycles tautomerizable e hana i ka paʻakai phosphonium e kōkua i ka hui ʻana o Sonogashira o nā heterocycles me nā alkynes like ʻole.No ka hoʻoulu ʻana o ka pā hoʻokahi o ka CO i loko o nā phenols a hoʻohui hou i ka hopena me ka phosphine oxide a i ʻole phosphite e hana i nā mea paʻa CP.