(R)-(-)-3-Pyrrolidinol Hydrochloride CAS 104706-47-0 Purity ≥99.7% (GC) Chiral Purity ≥99.7% Panipenem and Darifenacin hydrobromide Intermediate
Mea Hana Hana;Maʻemaʻe kiʻekiʻe a me ke kumu kūʻai hoʻokūkū
ʻO Shanghai Ruifu Chemical Co., Ltd. Nā Hui Kūʻai Kūʻai Kūʻai:
(R)-(-)-3-Pyrrolidinol Hydrochloride CAS: 104706-47-0
(S)-3-Hydroxypyrrolidine hydrochloride CAS: 122536-94-1
Ka waena o Panipenem (CAS 87726-17-8) a me Darifenacin hydrobromide (CAS 133099-07-7)
| Inoa Kimia | (R)-(-)-3-Pyrrolidinol Hydrochloride |
| Nā huaʻōlelo like | (R)-(-)-3-Hydroxypyrrolidine Hydrochloride;(R)-(-)-3-Hydroxypyrrolidine-HCl |
| Helu CAS | 104706-47-0 |
| Helu CAT | RF-CC102 |
| Maʻemaʻe / Kaʻina Hanana | ≥98.0% (GC) |
| Kūlana Kūʻai | Ma ka waihona, hoʻonui ʻia a hiki i nā tona |
| ʻĀpana Molekala | C4H10ClNO |
| Kaumaha Molecular | 123.58 |
| Lae hehee | 107.0 ~ 111.0 °C |
| Solubility i ka wai | ʻAneʻane Mākaʻikaʻi |
| Brand | Kemika Ruifu |
| 'ikamu | Nā kikoʻī |
| Ka nana aku | Keʻokeʻo-keʻokeʻo a hiki i ka ʻulaʻula ʻulaʻula Crystalline pauda |
| Maʻemaʻe / Kaʻina Hanana | ≥99.7% (GC) |
| Maʻemaʻe Chiral | ≥99.7% ee |
| Koena ma ka Ignition | ≤0.50% |
| Kahuli kiko'ī [α]D20 | -6.5°~ -8.5° (C=3.5 CH3OH) |
| ʻO kēlā me kēia haumia kanaka | ≤0.20% |
| Huina haumia | ≤0.30% |
| Kūlana hoʻāʻo | Kūlana ʻoihana |
| Hoʻohana | Nā Kūwaena Lapaʻau;Huina Kiral |
Kaʻina Hanana
Mea hana: GC mea kani (Shimadzu GC-2010)
Kona: DB-17 Agilent 30mX0.53mmX1.0μm
Ka wela o ka umu mua: 80 ℃
Ka manawa mua 2.0min
15 ℃/min
Ka wela wela o ka umu: 250 ℃
Ka manawa hope 20min
ʻO ke kinoea halihali Nitrogen
ʻAno kahe mau
Kahe 5.0mL/min
Māhele māhele 10:1
ʻO ka mahana hoʻoheheʻe: 250 ℃
ʻIke wela: 300 ℃
ʻO ka nui o ka injection 1.0μL
Pono e mālama ʻia ma mua o ka nānā ʻana:
1. Kūlana kolamu ma 240 ℃ no ka liʻiliʻi loa 30minutes.
2. E holoi pono i ka syringe a me ka liner injector maʻemaʻe no ka wehe ʻana i nā mea haumia o ka loiloi mua.
3. E holoi, maloʻo a hoʻopiha i ka diluent i loko o nā hue holoi syringe.
Hoʻomākaukau hoʻoheheʻe:
E hoʻomākaukau i ka solution 2% w/v sodium hydroxide i loko o ka wai.
Hoʻomākaukau maʻamau:
E kaupaona ma kahi o 100mg o (R)-3-hydroxyprrolidine hydrochloride maʻamau i loko o kahi hue, hoʻohui i 1mL o ka diluent a hoʻoheheʻe.
Hoʻomākaukau hoʻāʻo:
E kaupaona ma kahi o 100mg o ka laʻana hoʻāʻo i loko o kahi hue, hoʻohui i 1mL o ka diluent a hoʻoheheʻe.E hoʻomākaukau i ka lua.
Kaʻina hana:
Inject blank (diluent), hoʻomākaukau maʻamau a hoʻomākaukau hoʻāʻo me ka hoʻohana ʻana i nā kūlana GC ma luna.E haʻalele i nā piko ma muli o ka hakahaka.ʻO ka manawa paʻa o ka piko ma muli o (R) -3-hydroxyprrolidine ma kahi o 5.0min.
Nānā:
E hōʻike i ka hopena ma ke ʻano he awelika
Pūʻolo: ʻO ka ʻōmole, ʻeke ʻeke alumini, pahu pahu pahu, 25kg / pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;Palekana mai ka malamalama, ka ma'ū a me ka pest infestation.
ʻO Shanghai Ruifu Chemical Co., Ltd. ka mea hana nui a me ka mea hoʻolako o (R)-(-)-3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) me ke kūlana kiʻekiʻe, hoʻohana nui ʻia i ka synthesis organik, synthesis o nā intermediates pharmaceutical a me Active Pharmaceutical Ingredient (API) synthesis.
(R)-(-)-3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) he mea waena maʻamau i ka synthesis o Panipenem (CAS 87726-17-8) a me Darifenacin hydrobromide (CAS 133099-07-7).
(R)-(-)-3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) he chiral hydroxy derivative o pyrrlodine i hoʻohana ʻia i ka hoʻomākaukau ʻana i nā pūhui chiral niologically e like me ka muscarinic receptor antagonists a me nā mea antimicrobial.
Alanui o ka Synthesis o (R)-3-Hydroxypyrrolidine hydrochloride
(R) -4-chloro-3-hydroxybutanitrile me ka trimethyl chlorosilane i loko o ka dichloromethane solvent e loaʻa ai (R) -4-chloro-3-trimethylsiloxy butanitrile.(R) -4-chloro-3-trimethylsiloxyebutylamine a laila hydrogenated ma ka Pd / C catalyst. (R) -3-trimethylsiloxyepyrrolidine i loaʻa e ka sodium hydroxide apo pani pani.ʻO ka hope loa, ua loaʻa ka huahana (R) -3-hydroxypyrrolidine hydrochloride e ka mālama ʻana i ka waika hydrochloric concentrated a ua wehe ʻia ka hui pale trimethylsilyl.
