Ramelteon (TAK-375) CAS 196597-26-9 Maʻemaʻe >99.5% (HPLC)

Ua ʻae ʻia ʻo Ramelteon (CAS: 196597-26-9) e ka US Food and Drug Administration (FDA) ma Iulai 22, 2005, a laila ʻae ʻia e Pharmaceuticals and Medical Devices Agency (PMDA) ma Apr 16, 2010. kūʻai ʻia ʻo Rozerem® e Takeda,hiki ke hoʻohana ʻia no ka mālama ʻana i ka insomnia me ka paʻakikī o ka hiamoe ʻana, a loaʻa nā hopena paʻa i ka insomnia mau a me ka insomnia pōkole.Hiki i kēia huahana ke hoʻoikaika i ka ʻano 1 a me ka type 2 receptors o ka melatonin (MT1, MT2), hoʻonui i ka hiamoe hawewe lohi (SWS) a me ka hiamoe wikiwiki o ka maka (REW), a laila e hōʻemi ana i ka insomnia.ʻO Ramelteamide ka lāʻau lapaʻau maʻi insomnia mua ʻaʻole i lalo o ka mana kūikawā.ʻO kēia huahana he agonist receptor melatonin.Loaʻa iā ia kahi pilina kiʻekiʻe me ka melatonin MT1 a me MT2 receptors, a loaʻa kahi hopena agonistic kikoʻī a piha i ka MT1 a me MT2 receptors, akā ʻaʻole pili me ka mea loaʻa MT3.Eia kekahi, ʻaʻole ia e hoʻopaʻa i nā neurotransmitter receptors e like me GABA receptor complexes, a ʻaʻole ia e keakea i ka hana o ka hapa nui o nā enzymes i loko o kekahi ʻano.No laila, hiki iā ia ke pale aku i nā mea hoʻonāukiuki e pili ana i nā lāʻau lapaʻau GABA (ʻo ia ke kumu o nā ulia kaʻa, hāʻule a me nā haʻihaʻi).Etc.) a me ka hoʻohui lāʻau a me ka hilinaʻi.Loaʻa ʻo Rozerem® ma ke ʻano he papa kiʻiʻoniʻoni no ka hoʻohana waha, loaʻa iā 8 mg o Ramelteon manuahi.ʻO ka nui o ke kanaka makua i ʻōlelo ʻia he 8 mg i lawe ʻia i loko o 30 mau minuke mai ka moe ʻana.