Remdesivir GS-5734 CAS 1809249-37-3 COVID-19 API Kūlana Kiʻekiʻe
Mea Hana Hana Kalepa Remdesivir a me nā mea pili i waena me ke kūlana kiʻekiʻe
Remdesivir CAS 1809249-37-3
2-Ethyl-1-butanol CAS 97-95-0
Trimethylsilyl Cyanide CAS 7677-24-9
4-Nitrophenol CAS 100-02-7
2-Ethylbutyl ((S)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate CAS 1911578-98-7
N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-L-Alanine 2-ethylbutyl ester CAS 1354823-36-1
(S)-2-Ethylbutyl 2-Aminopropanoate Hydrochloride CAS 946511-97-3
Remdesivir Metabolite (GS-441524) CAS 1191237-69-0
Remdesivir N-2 Kūwaena CAS 1191237-80-5
2,3,5-Tri-O-benzyl-D-ribonolactone CAS 55094-52-5
7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine CAS 937046-98-5
Pyrrolo[1,2-F][1,2,4]Triazin-4-Amine CAS 159326-68-8
4-Amino-7-iodopyrrolo[2,1-f][1,2,4]triazine CAS 1770840-43-1
Inoa Kimia | Remdesivir |
Nā huaʻōlelo like | GS-5734;2-ethylbutyl ((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4] triazin-7-yl)-5-cyano -3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate |
Helu CAS | 1809249-37-3 |
Helu CAT | RF-API96 |
Kūlana Kūʻai | Ma ka waihona, ʻoi aku ka nui o ka hana a hiki i nā haneli kilogram |
ʻĀpana Molekala | C27H35N6O8P |
Kaumaha Molecular | 602.58 |
ʻO ka mānoanoa | 1.47±0.1 g/cm3 |
Brand | Kemika Ruifu |
'ikamu | Nā kikoʻī |
Ka nana aku | Keʻokeʻo i ka pauda paʻa keʻokeʻo |
ʻIkepili A | IR: Pono e kūlike ka spectrum absorption infrared o ka huahana me ko ka mea kuhikuhi |
ʻIkepili B | ʻO ka manawa paʻa HPLC e like me ka mea kuhikuhi |
Hoʻololi kikoʻī | -19.0° ~ -22.0° |
Ka hikiwawe | Solunle i loko o ka Methanol, hiki ke hoʻoheheʻe ʻia i loko o ka ethanol, hiki ke hoʻoheheʻe ʻia i ka Acetonitrile, hiki ʻole ke hoʻoheheʻe ʻia i ka wai. |
Na mea pili | |
ʻO kēlā me kēia haumia kanaka | ≤0.10% |
Huina paumaele | ≤1.0% |
RD-3.1 | ≤0.10% |
RD-C | ≤0.10% |
RD-D | ≤0.10% |
RD-E | ≤0.10% |
RP-Isomer | ≤0.10% |
Nitrophenol | ≤0.10% |
Nā mea hoʻoheheʻe koena | |
Methanol Dichloride | ≤6000ppm |
Acetone | ≤5000ppm |
Isopropyl Alcohol | ≤5000ppm |
Acetonitrile | ≤410ppm |
Dichloromethane | ≤600ppm |
Methyl tert Butyl Etera | ≤5000ppm |
Ethyl Acetate | ≤5000ppm |
Tetrahydrofuran | ≤720ppm |
n-Heptana | ≤5000ppm |
Hoʻāʻo | 98.0%~102.0% (I helu ʻia ma ke kumu maloʻo) |
Huina Aerobic | |
ʻAerobic Bacteria | ≤100cfu/g |
Huna a me Mold | ≤10cfu/g |
E. Coil | ʻinoʻino |
Endotoxin maʻi bacteria | ≤1.0EU |
Nā Metala Kaumaha | ≤20ppm |
Kūlana hoʻāʻo | Kūlana ʻoihana |
Hoʻohana | API, COVID-19 |
Pūʻolo: ʻO ka ʻōmole, ʻeke ʻeke alumini, pahu pahu pahu, 25kg / pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;Palekana mai ka malamalama, ka ma'ū a me ka pest infestation.
ʻO Remdesivir (CAS 1809249-37-3), i kūʻai ʻia ma lalo o ka inoa inoa Veklury, kahi lāʻau lapaʻau antiviral ākea ākea i hoʻomohala ʻia e ka hui biopharmaceutical Gilead Sciences.Hāʻawi ʻia ia ma o ka injection i loko o kahi vein.I ka wā maʻi maʻi COVID-19, ua ʻae ʻia ka remdesivir a i ʻae ʻia no ka hoʻohana ʻana i ka pilikia e mālama i ka COVID-19 ma kahi o 50 mau ʻāina.ʻO nā alakaʻi i hoʻonui ʻia mai ka World Health Organization i Nowemapa 2020 me kahi ʻōlelo aʻoaʻo kūʻē i ka hoʻohana ʻana o Remdesivir no ka mālama ʻana i ka COVID-19.Ua hoʻokumu mua ʻia ʻo Remdesivir e mālama i ka hepatitis C, a ua noiʻi ʻia no ka maʻi maʻi Ebola a me nā maʻi maʻi Marburg ma mua o ke aʻo ʻia ʻana ma ke ʻano he lapaʻau post-infection no COVID-19.ʻO ka hopena ʻaoʻao maʻamau i nā mea manawaleʻa olakino ke hoʻokiʻekiʻe ʻia ke kiʻekiʻe o ke koko o nā enzyme ate (he hōʻailona o nā pilikia ate).ʻO ka hopena ʻaoʻao maʻamau i ka poʻe me COVID-19 he nausea.Hiki i nā hopena ʻaoʻao ke komo i ka mumū o ka ate a me kahi hopena pili i ka infusion me ka nausea, ke koko haʻahaʻa, a me ka hou.ʻO Remdesivir kahi prodrug i manaʻo ʻia e ʻae i ka hoʻopuka intracellular o GS-441524 monophosphate a me ka biotransformation ma hope i GS-441524 triphosphate, kahi ribonucleotide analogue inhibitor o viral RNA polymerase.