Rivastigmine Tartrate CAS 129101-54-8 Hōʻike 98.0~102.0
ʻO Shanghai Ruifu Chemical Co., Ltd. ka mea hana nui o Rivastigmine Tartrate (CAS: 129101-54-8) me ke kūlana kiʻekiʻe.Hiki iā Ruifu Chemical ke hāʻawi aku i ka honua holoʻokoʻa, ke kumukūʻai hoʻokūkū, ka lawelawe maikaʻi loa, ka liʻiliʻi a me ka nui nui i loaʻa.E kūʻai aku iā Rivastigmine Tartrate,Please contact: alvin@ruifuchem.com
| Inoa Kimia | ʻO Rivastigmine Tartrate |
| Nā huaʻōlelo like | Exelon;ENA-713;Rivastigmine L-Tartrate;Rivastigmine Hydrogen Tartrate;CS-118;S-Rivastigmine Tartrate;3-[(S)-1-(Dimethylamino)ethyl]phenyl N-Ethyl-N-Methylcarbamate L-Tartrate;N-Ethyl-N-Methylcarbamic Acid 3-[(S)-1-(Dimethylamino)ethyl]phenyl Ester L-Tartrate |
| Kūlana Kūʻai | Ma ke Kahua, Hana Hana Kūʻai |
| Helu CAS | 129101-54-8 |
| CAS pili | 123441-03-2 |
| ʻĀpana Molekala | C14H22N2O2·C4H6O6 |
| Kaumaha Molecular | 400.43 g/mol |
| Lae hehee | 124.0 a 128.0 ℃ |
| Ka Poali Pono [a]20/D | +4.0° a i +7.0° (C=5, Methanol) |
| Ka hikiwawe | Hiki ke hoʻoheheʻe ʻia i ka Methanol |
| COA & MSDS | Loaʻa |
| Ke kumu | Shanghai, Kina |
| Brand | Kemika Ruifu |
| Nā mea | Nā Kūlana Nānā | Nā hualoaʻa |
| Ka nana aku | Keʻokeʻo a i ka pauka kristal keʻokeʻo | Hoʻokō |
| Hoʻāʻo | 98.0~102.0% (ma ka Anhydrous Basis) | 99.8% |
| Wai na Karl Fischer | ≤0.50% | 0.15% |
| Koena ma ka Ignition | ≤0.10% | 0.07% |
| Nā Metala Kaumaha (Pb) | ≤20ppm | <10ppm |
| Phenol haumia | ≤0.30% | <0.30% |
| DPTTA | ≤0.15% | <0.15% |
| Aole no hoi ka haumia | ≤0.15% | <0.15% |
| ʻO ka haumia Carbamate | ≤0.15% | <0.15% |
| Etera haumia | ≤0.15% | <0.15% |
| ʻO nā mea haumia ʻē aʻe | ≤0.10% | <0.10% |
| Huina haumia | ≤0.50% | <0.50% |
| R-Enantiomer | ≤0.30% | <0.30% |
| Infrared Spectrum | Kūlike me ka Hoʻolālā | Hoʻokō |
| 1H NMR Spectrum | Kūlike me ka Hoʻolālā | Hoʻokō |
| Ka hopena | Ua hoʻāʻo ʻia ka huahana a hoʻokō me ka USP35 Standard | |
Pūʻolo:ʻO ka ʻōmole Fluorinated, ʻeke ʻeke alumini, 25kg / pahu pahu pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E hoʻopaʻa paʻa i ka pahu a mālama i loko o kahi hale kūʻai maloʻo a maloʻo (2 ~ 8 ℃) a me kahi hale kūʻai maikaʻi mai nā mea like ʻole.E pale i ka malamalama a me ka wai.
Hoʻouna:Hāʻawi i ka honua ma ka lewa, e FedEx / DHL Express.Hāʻawi wikiwiki a hilinaʻi hoʻi.
ʻO Rivastigmine Tartrate
C14H22N2O2·C4H6O6 400.42
Ethylmethylcarbamic acid, 3-[(S) -1-(dimethylamino)ethyl]phenyl ester, (2R,3R) -2,3-dihydroxybutanedioate;
(S)-3-[1-(Dimethylamino)ethyl]phenyl ethylmethylcarbamate, hydrogen tartrate [129101-54-8].
Rivastigmine 250.34 [123441-03-2].
HOAKAKA
Aia ka Rivastigmine Tartrate i ka NLT 98.0% a me ka NMT 102.0% o ka nui i kapa ʻia o C14H22N2O2·C4H6O6, i helu ʻia ma ke kumu anhydrous.
IKE
• A. Hoʻopili ʻana i ka infrared <197K>
B. ʻO ka manawa paʻa o ke kiʻekiʻe nui o ka Sample solution e pili ana i ka ʻōnaehana kūpono kūpono, e like me ka loaʻa ʻana ma ka hoʻāʻo no nā Organic Impurities, Kaʻina 2: Enantiomeric Purity.
HANA
• Kaʻina hana
Paʻa: 8.6 mg/mL o monobasic ammonium phosphate.Hoʻoponopono me ka hoʻonā amonia i kahi pH o 7.0.
Māhele paʻa: Methanol, acetonitrile, a me Buffer (15:15:70)
ʻO ka hoʻonā kūpono o ka ʻōnaehana: 0.05 mg/mL kēlā me kēia USP Rivastigmine Pūʻulu Pili A RS a me USP Rivastigmine Pili pū pū B RS ma ka pae Mobile.
Haʻina maʻamau: 0.2 mg/mL o USP Rivastigmine Tartrate RS ma ka pae Mobile
Laʻana hoʻonā: 0.2 mg/mL o Rivastigmine Tartrate ma ka pae Mobile
Pūnaehana Chromatographic
(E nana Chromatography <621>, Pūnaehana Pono.)
Ke ano: LC
ʻIke: UV 215 nm
kolamu: 4.6-mm × 25-cm;5-µm paʻi L7
Kahe kahe: 1.2 mL / min
Ka nui o ka hoʻopio: 20 µL
[Note-Hiki ke hoʻololi ʻia ke kahe kahe ʻana i 1.5 mL/min, inā pono, e hoʻokō i kahi manawa paʻa i manaʻo ʻia o rivastigmine ma kahi o 10 min.]
Kūpono ʻōnaehana
Nā Laʻana: Haʻina kūpono ʻōnaehana a me ka hopena maʻamau
Nā koi kūpono
Hoʻoholo: NLT 1.5 ma waena o ka pūhui pili rivastigmine A a me ka pūhui pili rivastigmine B.
ʻO ka pono o ke kolamu: NLT 5000 mau papa manaʻo, Haʻina maʻamau
Huli huʻi: NMT 3.0, Haʻina maʻamau
Hoʻokaʻawale maʻamau pili: NMT 2.0%, Haʻina maʻamau
Kānāwai
Nā Laʻana: Haʻina maʻamau a me ka hāʻina Laʻana
E helu i ka pākēneka o C14H22N2O2·C4H6O6 ma ka ʻāpana o Rivastigmine Tartrate i lawe ʻia:
Ka hopena = (rU/rS) × (CS/CU) × 100
rU = pane kiʻekiʻe mai ka hāʻina Laʻana
rS = pane kiʻekiʻe mai ka hoʻonā maʻamau
CS = ka hoʻopaʻa ʻana o ka hopena maʻamau (mg/mL)
CU = ka hoʻopaʻa ʻana o ka hāpana laʻana (mg/mL)
Nā pae hoʻohālikelike: 98.0% -102.0% ma ke kumu anhydrous
NA mea haumia
Nā mea haumia ʻole
• Ke koena ma ka ʻā ʻana <281>: NMT 0.1%
• Nā Metala Kaumaha, Ka Hana II <231>: NMT 20 ppm
Nā mea haumia kino
• Kaʻina hana 1
ʻO ka pae kelepona a me ka ʻōnaehana kūpono: E hoʻomau e like me ke kuhikuhi ʻana ma ka Assay.
Hoʻonā maʻamau: 1.0 µg/mL o USP Rivastigmine Tartrate RS ma ka pae Mobile
Laʻana hoʻonā: 1.0 mg / mL o Rivastigmine Tartrate ma ka pae Mobile
Pūnaehana Chromatographic: E hoʻomau e like me ke kuhikuhi ʻana ma ka Assay.
(E nana Chromatography <621>, Pūnaehana Pono.)
Kūpono ʻōnaehana
Nā Laʻana: Haʻina kūpono ʻōnaehana a me ka hopena maʻamau
Nā koi kūpono
Hoʻoholo: NLT 1.5 ma waena o ka pūhui pili rivastigmine A a me ka pūhui pili rivastigmine B.
Hoʻokaʻawale maʻamau pili: NMT 10%, Haʻina maʻamau
Nānā [Note-ʻO ka manawa holo he 8 manawa ka manawa paʻa o ka piko rivastigmine.]
Nā Laʻana: Haʻina maʻamau a me ka hāʻina Laʻana
E helu i ka pākēneka o kēlā me kēia haumia i ka ʻāpana o Rivastigmine Tartrate i lawe ʻia:
Ka hopena = (rU/rS) × (CS/CU) × (1/F) × 100
rU = pane kiʻekiʻe no kēlā me kēia haumia mai ka hāʻina Laʻana
rS = pane kiʻekiʻe mai ka hoʻonā maʻamau
CS = ka manaʻo o ka USP Rivastigmine Tartrate RS i ka hopena maʻamau (mg/mL)
CU = ka hoʻopaʻa ʻana o ka Rivastigmine Tartrate i ka hāʻina Laʻana (mg/mL)
F = kumu pane pili (e nānā i ka Papa Hoʻomaʻemaʻe 1)
Nā pae ʻae ʻae
Nā haumia o kēlā me kēia kanaka: E nānā i ka Papa Hoʻomaʻemaʻe 1.
Huina haumia: NMT 0.5%
Helu 1
| inoa | Manawa Paa Pilina | Mea pane pili | Nā Koina ʻae NMT % |
| Tartrate | 0.18 | — | ʻAʻole mālama |
| Phenol haumia | 0.28 | 1.6 | 0.3 |
| DPTTAb | 0.46 | 0.83 | 0.15 |
| ʻAʻole haumiac | 0.57 | 1.2 | 0.15 |
| Rivastigmine | 1.0 | 1.0 | — |
| ʻO Carbamate haumia | 4.1 | 1.3 | 0.15 |
| Etera haumia | 6.5 | 1.4 | 0.15 |
| ʻO nā mea haumia ʻē aʻe | — | 1.0 | 0.1 |
a (S)-3-[1-(Dimethylamino)ethyl]phenol.
b (+)-Di-(p-toluoyl)-d-tartaric acid (rivastigmine pili pūhui A).
c (S)-3-[1-(Dimethylamino)ethyl]phenyl dimethylcarbamate (huihui pili rivastigmine B).
d 3-Nitrophenyl ethyl(methyl)carbamate.
e (S)-N,N-Dimethyl-1-[3-(4-nitrophenoxy)phenyl]ethanamine.
• Ke Kaʻina Hana 2: Enantiomeric Purity
Hoʻopaʻa: E hoʻololi i 1.78 g o ka sodium phosphate dihydrate dibasic a me 1.38 g o ka sodium phosphate monobasic i loko o kahi pahu volumetric 1000-mL.E hoʻoheheʻe i loko a hoʻoheheʻe me ka wai i ka nui.Hoʻoponopono me ka waikawa phosphoric i kahi pH o 6.0.
Māhele Mobile: E hoʻololi i 20 mL o ka acetonitrile a me 205 µL o N,N-dimethyloctylamine i loko o kahi pahu volumetric 1000-mL, a hoʻoheheʻe me ka Buffer i ka nui.
Haʻina maʻamau: 0.1 µg/mL o USP Rivastigmine Tartrate R-Isomer RS ma ka pae Mobile
ʻO ka hoʻonā naʻauao: 0.05 µg/mL o USP Rivastigmine Tartrate R-Isomer RS ma ka pae Mobile, Hoʻonā maʻamau
ʻO ka hopena kūpono o ka ʻōnaehana: 100 µg/mL o USP Rivastigmine Tartrate RS a me 0.1 µg/mL o USP Rivastigmine Tartrate R-Isomer RS ma ka pae Mobile.
Laʻana hoʻonā: 100 µg/mL o Rivastigmine Tartrate ma ka pae Mobile
Pūnaehana Chromatographic
(E nana Chromatography <621>, Pūnaehana Pono.)
Ke ano: LC
ʻIke: UV 200 nm
kolamu: 4.0-mm × 10-cm;kāʻei L41
Kahe kahe: 0.5 mL / min
Ka nui o ka hoʻopio: 20 µL
Kūpono ʻōnaehana
Nā Laʻana: Haʻina maʻamau, Haʻina Sensitivity, a me ka ʻōnaehana kūpono
Nā koi kūpono
Hoʻoholo: NLT 0.8 ma waena o nā piko enantiomer, ʻO ka hoʻonā kūpono kūpono
[Note-ʻO ke kauoha elution ka R-enantiomer, a ukali ʻia e ka piko rivastigmine, ʻo ia ka S-enantiomer.]
Lakiō hōʻailona-a-noise: NLT 10, Hoʻonā ʻike
Hoʻokaʻawale maʻamau pili: NMT 10%, Haʻina maʻamau
Kānāwai
Nā Laʻana: Haʻina maʻamau a me ka hāʻina Laʻana
E helu i ka pākēneka o ka R-enantiomer ma ka hapa o Rivastigmine Tartrate i lawe ʻia:
Ka hopena = (rU/rS) × (CS/CU) × 100
rU = pane kiʻekiʻe o R-enantiomer mai ka Haʻina Haʻawina
rS = pane kiʻekiʻe o R-enantiomer mai ka hoʻonā Kūlana
CS = ka hoʻopaʻa ʻana o R-enantiomer i ka hoʻonā maʻamau (µg/mL)
CU = ka hoʻopaʻa ʻana o Rivastigmine Tartrate i ka hāʻina Laʻana (µg/mL)
Nā pae ʻae ʻae: NMT 0.3% o ka R-enantiomer
NA HOAO KUAI
• Ka Hoʻoholo Wai, ʻAno Ia <921>: NMT 0.5%
NA KOI HOU
• Hoʻopaʻa a me ka mālama ʻana: E mālama i loko o nā pahu paʻa, a mālama i ka lumi wela.
• Nā Kūlana Kūlana USP <11>
USP Rivastigmine Tartrate RS
USP Rivastigmine Puhui Pili A RS
Di-p-toluoyl-d-(+)-tartaric acid monohydrate.
C20H20O9 404.37
USP Rivastigmine Puhui Pili B RS
N,N-Dimethylcarbamic acid-3-[1-(dimethylamino)ethyl]phenyl ester.
C13H20N2O2 236.32
USP Rivastigmine Tartrate R-Isomer RS
Pehea e kūʻai ai?E ʻoluʻolu e kelepona maiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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Nā ID UN UN 2811 6.1 / PGII
WGK Kelemānia 3
RTECS FA9550000
HS Code 29242990
Papa Hazard 6.1
Hui Pūʻulu III
ʻO Rivastigmine Tartrate (CAS: 129101-54-8) ka tartrate o rivastigmine, he lāʻau lapaʻau no ka mālama ʻana i ka maʻi o Alzheimer.ʻO Rivastigmine kahi physostigmine derivative, i hoʻomohala maikaʻi ʻia no ka manawa mua e Novartis, Switzerland.ʻO ka inoa kālepa he exelon, a he ʻano benzyl carbamate ka mole, ʻo ia ka carbamate brain-cholinesterase inhibitor, hiki ke kāohi i ka acetylcholinesterase a me butyrylcholinesterase i ka manawa like, a hoʻoikaika i ka conduction nerve cholinergic ma ka hoʻopaneʻe ʻana i ka degradation o acetylcholine i hoʻokuʻu ʻia e cholinergic neurons.Hiki iā ia ke hoʻomaikaʻi i ka cognitive dysfunction mediated by cholinergic, ma laila e hoʻomaikaʻi ai i ka hopena cognitive o nā maʻi me ka maʻi o Alzheimer.ʻO ka hiki ke hoʻopaʻa i ka protein plasma o rivastigmine he nāwaliwali, maʻalahi ke hele i ka pale koko-lolo, a he kiʻekiʻe ke koho o ka lolo.ʻAʻole hiki iā ia ke koho wale i nā wahi palupalu o ka cerebral cortex a me ka hippocampus, akā makemake pū kekahi i nā subtypes nui o AChE i loko o ka lolo, hiki ke hōʻemi i nā hopena ʻaoʻao cholinergic peripheral i ka wā e hana ana i nā hopena curative.ʻO ka hapalua o ke ola o ka rivastigmine tartrate i loko o ke kino he pōkole a lōʻihi ka manawa hana.ʻAʻole like me ka tacrine, ʻoi aku ka ikaika o kēia huahana ma ka G1 enzyme i ka hippocampus a me ka cortex.Hoʻohana ʻia ia no ka mālama ʻana i ka maʻi dementia ʻo Alzheimer mai ka haʻahaʻa a haʻahaʻa, ka mea i manaʻo ʻia he maʻi Alzheimer a i ʻole maʻi Alzheimer.
1. E like me ka acetylcholinesterase inhibitor, hiki i ka rivastigmine bicartrate ke hoʻomaikaʻi i ka hopena o ka succinylcholine muscle relaxant.No laila, pono e loaʻa kahi manawa intermittent kūpono e ho'ōki i ka lawe ʻana i kēia huahana ma mua o ka anesthesia.Pono e hui pū ʻia kēia huahana me nā hoʻomākaukau cholinergic a anticholinergic ʻē aʻe, a pono e mālama ʻia (e nānā i ka [Drug Interaction]).
2. Ma muli o ko lākou hopena pharmacological, hiki i nā mea hoʻopaneʻe cholinesterase ke loaʻa nā hopena ʻehaʻeha o ke aʻalolo ma ka puʻuwai.E like me nā lāʻau cholinergic ʻē aʻe, pono e mālama ʻia i ka wā e hāʻawi ʻia ai i nā poʻe maʻi me ka maʻi maʻi sinus a i ʻole nā poka puʻuwai ʻē aʻe (e ʻike i nā Adverse Reactions).
3. Hiki ke hoʻonui ʻia ka hoʻoulu ʻana o ke aʻalolo Cholinergic.ʻOiai ʻaʻole i ʻike ʻia kahi hōʻike o ka hōʻino nui ʻana o nā hōʻailona like i ka wā o ka hoʻokolohua lapaʻau, nā poʻe maʻi me ka nui o ka pilikia o ka maʻi ʻōpū, e like me ka poʻe me ka mōʻaukala o ka maʻi ʻeha a i ʻole ka poʻe e loaʻa ana i ka mālama ʻana me nā lāʻau anti-inflammatory non-steroidal. pono e hoʻohana me ka akahele.
4. E like me nā cholinesterase inhibitors ʻē aʻe, pono e hoʻohana ʻia nā maʻi me ka mōʻaukala o ka hānō a i ʻole nā maʻi pulmonary obstructive ʻē aʻe me ka akahele.
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