Roflumilast CAS 162401-32-3 Hōʻike 99.0~101.0% API
ʻO Ruifu Chemical Supply Roflumilast Intermediates:
Roflumilast CAS 162401-32-3
4-Amino-3,5-Dichloropyridine CAS 22889-78-7
Inoa Kimia | ʻO Roflumilast |
Nā huaʻōlelo like | 3-(Cyclopropylmethoxy)-N-(3,5-Dichloropyridin-4-yl)-4-(Ddifluoromethoxy)benzamide |
Helu CAS | 162401-32-3 |
Helu CAT | RF-PI2075 |
Kūlana Kūʻai | Ma ka waihona, hoʻonui ʻia a hiki i nā tona |
ʻĀpana Molekala | C17H14Cl2F2N2O3 |
Kaumaha Molecular | 403.21 |
ʻO ka mānoanoa | 1.471±0.060 g/cm3 |
ʻO ka ʻike | Paʻa wela |
Brand | Kemika Ruifu |
'ikamu | Nā kikoʻī |
Ka nana aku | Keʻokeʻo a ʻaneʻane keʻokeʻo Crystalline pauda |
Ka hikiwawe | Hiki ke hoʻoheheʻe ʻia i ka acetone, hiki ke hoʻoheheʻe ʻia i ka acetronitrile, hiki ʻole ke hoʻoheheʻe ʻia i ka ethanol anhydrous, hiki ʻole ke hoʻoheheʻe ʻia i ka wai. |
Lae hehee | 157.0~162.0 ℃ |
Nalo ma ka maloo | <0.50% |
Koena ma ka Ignition | ≤0.10% |
Nā Metala Kaumaha | ≤10ppm |
Klorida | ≤0.01% |
ʻIkepili A. UV | ʻO ka lōʻihi o ka nalu o ka absorption kiʻekiʻe ma 213 ~ 251nm |
ʻIkepili B. IR | 'O ka IR absorption spectrum o ka la'ana e pili ana i ko ka mea kuhikuhi |
ʻIkepili C. | Hōʻike ia i ka hopena o Fluoride |
Na mea pili | |
Hoʻokahi haumia | ≤0.10% |
Huina paumaele | <0.50% |
Nā mea hoʻoheheʻe koena | |
Tert-Butanol | <0.10% |
Tetrahydrofuran | <0.072% |
Toluene | <0.089% |
N,N-Dimethylformamide | <0.088% |
Hoʻāʻo | 99.0~101.0% (Ka helu ʻia ma ke kumu maloʻo) |
Kūlana hoʻāʻo | Kūlana ʻoihana |
Hoʻohana | API;COPD |
Pūʻolo: ʻOmole, ʻeke ʻeke Aluminum, 25kg / pahu pahu pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;E pale i ka malamalama a me ka wai
ʻO Roflumilast (CAS: 162401-32-3) he mea hoʻopaneʻe oral phosphodiesterase-4 (PDE-4) koho a me kahi pūhui benzamide.Ua hoʻomohala ʻia e ka hui Kelemania ʻo Altana ma 1993 a ʻo ia wale nō ka waha PDE-4 inhibitor i hoʻohana ʻia no ka mālama ʻana i nā maʻi ʻeha hanu i ʻae ʻia no ke kūʻai aku.ʻO Roflumilast ka lāʻau lapaʻau mua loa o kona ʻano e hoʻopaʻa i ka maʻi pulmonary obstructive maʻi maʻi (COPD), a ʻo ia hoʻi ka lāʻau anti-inflammation waha mua i hoʻomohala ʻia no nā maʻi COPD.Hiki i kona mau waiwai kūʻokoʻa ke kōkua i ka hoʻoponopono ʻana i ka COPD: ke hoʻohana pū ʻia me nā bronchodilators e mālama i nā maʻi COPD koʻikoʻi loa, hiki iā Roflumilast ke loaʻa ka pōmaikaʻi o ka hoʻohaʻahaʻa hou ʻana i nā hōʻailona a me ka helu deterioration, no laila e lilo ia i lāʻau lapaʻau mua e kuhikuhi ana i nā maʻi me ka phenotype-spAecific deteriorating COPD. a me ke keakea nui o ka ea e pili ana i ka ma'i ma'i a me ka phlegm nui.Ma waho aʻe o ka lāʻau lapaʻau no ka COPD koʻikoʻi, hiki ke hoʻohana ʻia ʻo Roflumilast e pale a mālama i nā maʻi o ka ʻōpū hanu holoholona, ka ʻuʻu mucosa bronchitis nui, bronchitis asthmatic, a me ka bronchitis a me ka air sacculitis i hui pū ʻia me ka huna ʻana o ka ʻōpū hanu.