ʻO Sitagliptin Phosphate Monohydrate CAS 654671-77-9 Maʻemaʻe >99.0% (HPLC) API Hale Kūʻai Kūlana Kiʻekiʻe

ʻO Sitagliptin Phosphate Monohydrate (CAS: 654671-77-9), he lāʻau hou no ka mālama ʻana i ka maʻi maʻi type 2.I ʻAukake 2009, ua ʻae ʻia ka lāʻau lapaʻau e ka European Union ma ke ʻano he lāʻau lapaʻau mua no ka mālama ʻana i ka maʻi diabetes type 2.ʻO Sitagliptin Phosphate ka mea mua i ʻae ʻia e ka FDA i ka dipeptidyl peptidase-IV inhibitor e hoʻohana ʻia i ka mālama ʻana i ka maʻi diabetes type 2 ma kahi mamao, ma lalo o ka inoa kālepa Januvia.ʻO Dipeptidylpeptidase Ⅳ (DPP-Ⅳ) wikiwiki a hoʻohaʻahaʻa i ka GLP-1, GLP-1, ʻo ia ka mea hoʻoulu maikaʻi loa o ka hana ʻana o ka insulin a me ka huna ʻana No laila, hiki i ka inhibition o DPP-IV ke hoʻonui i ka hana o ka endogenous GLP-1, a laila e hoʻonui ai i ke koko. ka pae o ka insulin, ma laila e hoʻemi a mālama i nā pae glucose koko i nā maʻi maʻi maʻi.I kēia manawa, ua hōʻoia ka lāʻau lapaʻau ʻo DPP-IV inhibitor kahi ʻano hou o ka lāʻau anti-diabetic, a hōʻike nā hopena lapaʻau he hopena hypoglycemic maikaʻi nā lāʻau.Ma muli o ka hana ʻana o ka GLP-1 i ka glucose i ka hoʻoikaika ʻana i ka hana ʻana a me ka huna ʻana o ka insulin, ʻaʻole hiki mai nā hopena ʻino maʻamau e like me ka hypoglycemia a me ka piʻi ʻana o ke kaumaha ma muli o ka hoʻohana ʻana i nā lāʻau antidiabetic.