ʻO Sitagliptin Triazole Hydrochloride CAS 762240-92-6 Maʻemaʻe > 99.0% (HPLC) Hale Hana Kiʻekiʻe
Hoʻolako i nā mea kikowaena pili i ka Sitagliptin Phosphate Monohydrate:
Sitagliptin API CAS 486460-32-6
Sitagliptin Phosphate Monohydrate API CAS 654671-77-9
2,4,5-Trifluorophenylacetic Acid CAS 209995-38-0
Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid CAS 486460-00-8
Sitagliptin Triazole Hydrochloride CAS 762240-92-6
Sitagliptin Phosphate Monohydrate Intermediate CAS 486460-21-3
Inoa Kimia | 3-(Trifluoromethyl)-5,6,7,8-tetrahydro- [1,2,4] triazolo [4,3-a] pyrazine Hydrochloride |
Nā huaʻōlelo like | Sitagliptin Triazole Hydrochloride;ʻO Sitagliptin Intermediate A |
Helu CAS | 762240-92-6 |
Helu CAT | RF-PI1193 |
Kūlana Kūʻai | Ma ka waihona, ʻoi aku ka nui o ka hana a hiki i nā tona |
ʻĀpana Molekala | C6H7F3N4·HCl |
Kaumaha Molecular | 228.60 |
Lae hehee | 236.0~246.0 ℃ |
Ka hoʻoheheʻe | Hiki ke hoʻoheheʻe ʻia i ka Methanol |
Brand | Kemika Ruifu |
'ikamu | Nā kikoʻī |
Ka nana aku | Keʻokeʻo a i ka pauka kristal keʻokeʻo |
ʻIke ʻia e HPLC | ʻO ka manawa paʻa o ka laʻana ua kūlike me ka maʻamau kuhikuhi |
ʻIke ʻia e IR | Hoʻokō |
Nalo ma ka maloo | <0.50% |
Na mea pili | |
ʻO kēlā me kēia haumia hoʻokahi | <0.50% |
Huina paumaele | <1.00% |
Metala Kaumaha | <20ppm |
Maʻemaʻe / Kaʻina Hanana | >99.0% (HPLC) |
Kūlana hoʻāʻo | ʻOihana Kūlana |
Hoʻohana | Ka waena o Sitagliptin Phosphate Monohydrate (CAS: 654671-77-9) |
Pūʻolo: ʻO ka ʻōmole, ʻeke ʻeke alumini, 25kg / pahu pahu pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;E pale i ka malamalama a me ka wai.
ʻO 3-(Trifluoromethyl) -5,6,7,8-tetrahydro- [1,2,4] triazolo [4,3-a] pyrazine Hydrochloride (CAS: 762240-92-6) he mea waena o Sitagliptin Phosphate Monohydrate ( CAS: 654671-77-9), he mea hoʻopaneʻe DPP4 koho i ka waha-bioavailable i ʻike ʻia ma o ka loiloi ʻana o kahi papa o nā mea hoʻopaneʻe DPP4 i loaʻa i ka β-aminoacid.Hoʻohaʻahaʻa ia i ka hana DPP4 ma ke ʻano hoʻomau ma hope o ka hoʻohana ʻana i hoʻokahi manawa i kēlā me kēia lā, mālama i nā pae holoʻokoʻa o GIP paʻa a me GLP1 ma hope o ka ʻai ʻana i nā haʻawina koʻikoʻi a mau loa a hoʻemi i nā pae glucose koko me ka piʻi ʻole o ka hypoglycaemia.Hoʻohana ʻia ʻo Sitagliptin Phosphate (STG) e mālama i ka DM type 2 no ka mea e hoʻomaikaʻi i ka mana glycemic ma o ka hoʻonui ʻana i nā pae o nā hormones incretin ikaika, GLP-1 (peptide-1) a me GIP (glucose-dependent insulinotropic peptide).Ua ʻae ʻia ʻo STG e ka FDA i ka makahiki 2006.