Tacrolimus FK-506 Fujimycin CAS 104987-11-3 Hale Hana API Maʻemaʻe Kiʻekiʻe
Mea Hana me ka Maʻemaʻe kiʻekiʻe a me ka maikaʻi paʻa
Inoa Kemika: Tacrolimus
Synonyms: FK-506;Fujimycin
CAS: 104987-11-3
API, Mea Kiʻekiʻe, Hana Kalepa
Inoa Kimia | Tacrolimus |
Nā huaʻōlelo like | FK-506;Fujimycin |
Helu CAS | 104987-11-3 |
Helu CAT | RF-API46 |
Kūlana Kūʻai | Ma ka waihona, hoʻonui ʻia a hiki i nā tona |
ʻĀpana Molekala | C44H69NO12 |
Kaumaha Molecular | 804.02 |
Brand | Kemika Ruifu |
'ikamu | Nā kikoʻī |
Ka nana aku | ʻO ka pauka maikaʻi keʻokeʻo a i ʻole melemele ʻeleʻele, ʻaʻala ʻole, ʻono kūikawā |
ʻIkepili | Pono ʻo Positive Reaction |
Maopopo | E hoʻokō me ke Kūlana |
pH | 5.0~6.0 |
Klorida | ≤0.014% |
Sulphate | ≤0.029% |
Nā Metala Kaumaha (Pb) | ≤10ppm |
Arsenic | ≤0.0002% |
Māmā (KF) | ≤8.0% |
Koena ma ka Ignition | 18.0%~22.0% |
Hoʻāʻo | ≥72.0% (HPLC, ma ke kumu maloʻo) |
Kūlana hoʻāʻo | Kūlana ʻoihana |
Hoʻohana | API |
Pūʻolo: ʻO ka ʻōmole, ʻeke ʻeke alumini, pahu pahu pahu, 25kg / pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;Palekana mai ka malamalama, ka ma'ū a me ka pest infestation.
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ʻO Tacrolimus (ʻo FK-506 a i ʻole Fujimycin) he lāʻau immunosuppressive nona ka hoʻohana nui ʻana ma hope o ka hoʻololi ʻana o ke kino e hōʻemi i ka hana o ka ʻōnaehana pale o ka mea maʻi a no laila ka pilikia o ka hōʻole ʻana o ke kino.Hoʻohana ʻia ia i loko o kahi hoʻomākaukau topical i ka mālama ʻana i ka dermatitis atopic koʻikoʻi, uveitis refractory koʻikoʻi ma hope o ka hoʻololi ʻana i ka iwi iwi, a me ke kūlana ʻili vitiligo.Ua lawe mua ʻia ʻo Tacrolimus mai ka hupa fermentation o Streptomyces tsukuba, kahi microbe lepo i loaʻa ma Tsukuba, Iapana.Ua loaʻa ka inoa tacrolimus ma ka lawe ʻana i ka 't' no Tsukuba, ka inoa o ka mauna kahi i lawe ʻia ai ka hāpana lepo, 'acrol' no ka macrolide a me 'imus' no ka immunosuppressant.ʻOiai ʻaʻole pili i ka cyclosporin, hōʻike ʻo tacrolimus i kahi ʻano like o nā hopena immunosuppressive i kēia mea hana ma ka pae cellular a me ka molecular.Ua hōʻike ʻia nā haʻawina mua he immunosuppressant ikaika ka tacrolimus, e hōʻike ana ma kahi o 100-fold ka nui o ka ikaika in vitro ma mua o ka cyclosporin i ke kāohi ʻana i ka hoʻoulu ʻana o ke cell T.Ma hope o nā haʻawina vivo ua hōʻike ʻia ka tacrolimus i mea maikaʻi i ka hoʻopaʻa ʻana i ka maʻi autoimmune kūʻokoʻa a me ka hoʻokolohua, a me ka pale ʻana i ka allograft a me ka xenograft hōʻole i nā ʻano holoholona o ka hoʻololi ʻana o ke kino.I ka hoʻomaka ʻana, ua hoʻohana ʻia ka tacrolimus no ka immunosuppression systemic o nā maʻi i hoʻopaʻa ʻia i nā transplant allograft e hoʻōki iā lākou mai ka hōʻole ʻana i kā lākou mau grafts hou.ʻAʻole naʻe, ma muli o ka pōmaikaʻi o ka serendipity o ka ʻepekema, ua ʻike ʻia e hiki i ka tacrolimus ke hana i nā hopena maikaʻi i nā maʻi ʻili i kekahi o nā maʻi i hoʻololi ʻia.ʻO ka loaʻa ʻana o ka tacrolimus ua alakaʻi i ka ʻike nui ʻana i ka ʻili ʻili, no ka laʻana o ka dermatitis atopic.Ma hope mai, ua hōʻike ʻia nā noi topical ʻē aʻe o tacrolimus a ke hoʻonui mālie nei ka hoʻohana ʻana o kēia mea hana i ka dermatology.
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