Tenofovir Alafenamide Hemifumarate TAF CAS 1392275-56-7 API Factory Anti-HIV Mea Kiʻekiʻe
Nā Mea Kūʻai Kūʻai ʻo Tenofovir e pili ana:
Tenofovir CAS: 147127-20-6
Tenofovir Disoproxil Fumarate CAS 202138-50-9
Tenofovir Alafenamide Hemifumarate CAS 1392275-56-7
Chloromethyl Isopropyl Carbonate CAS 35180-01-9
Diethyl (p-Toluenesulfonyloxymethyl)phosphonate CAS 31618-90-3
(R)-(+)-Propylene Carbonate CAS 16606-55-6
(R)-9-(2-Hydroxypropyl)adenine CAS 14047-28-0
Diethyl (Hydroxymethyl)phosphonate CAS 3084-40-0
Adenine CAS 73-24-5
Inoa Kimia | ʻO Tenofovir Alafenamide Hemifumarate |
Nā huaʻōlelo like | TAF;GS-7340 Hemifumarate |
Helu CAS | 1392275-56-7 |
Helu CAT | RF-API91 |
Kūlana Kūʻai | Ma ka waihona, ʻoi aku ka nui o ka hana a hiki i nā haneli kilogram |
ʻĀpana Molekala | C25H33N6O9P |
Kaumaha Molecular | 592.55 |
Ka Mahana Waihona | Hoʻopaʻa ʻia i loko o ka maloʻo, ka wela lumi |
Brand | Kemika Ruifu |
'ikamu | Nā kikoʻī |
Ka nana aku | Keʻokeʻo a aneane keʻokeʻo keʻokeʻo a i ʻole ka pauka Crystalline |
Ka hikiwawe | Hiki ke hoʻoheheʻe ʻia i ka Dimethylformamide, a me ka Methanol;Hiki i ka wai a me ka THF;Hiki ke hoʻoheheʻe ʻia i loko o ka Acetonitrile a ʻaʻole hiki ke hoʻoheheʻe ʻia i ka Dichloromethane a me Toluene |
ʻIkepili A | Pono e kūlike ka spectra absorption IR me ka kuhikuhi |
ʻIkepili B | ʻO ka manawa paʻa o ka piko nui o ka hāpana hāpana i loko o ka chromatogram hoʻoholo maʻiʻo e kūlike me kēlā o ka hopena kuhikuhi. |
ʻIkepili C | ʻO ka manawa paʻa ʻo Fumaric Acid o ka piko nui i ka chromatogram hoʻoholo maʻiʻo e kūlike me ka piko o ka kuhikuhi. |
Waiwai (na KF) | ≤1.0% |
Akaka o ka Haʻina | ʻAʻohe mea ʻike ʻia i loko o 2% (w/v) o ka wehewehe ʻana i ka Methanol Solution |
Koena Solvent | |
Acetonitrile | ≤410ppm |
Ethanol | ≤5000ppm |
Dichloromethane | ≤600ppm |
Toluene | ≤890ppm |
Koena ma ka Ignition | ≤0.10% |
Nā Metala Kaumaha | ≤20ppm |
Na mea pili | |
PMPA | ≤1.0% |
PMPA Anhydride | ≤0.75% |
Phenyl PMPA hoʻokahi | ≤1.0% |
ʻO nā mea haumia ʻole i hōʻike ʻia | ≤0.15% |
Huina paumaele | ≤2.0% |
Isomer | ≤1.0% |
ʻO ka maʻiʻo o ka Fumaric Acid | 9.0% ~ 13.0% (ma ke kumu anhydrous) |
Palena Microbial | |
Huina Aerobic Microbial Helu | ≤1000CFU/g |
Huina Huna a me Molds | ≤100CFU/g |
Escherichia Coli | ʻAʻole |
Hoʻāʻo | 98.0% ~ 102.0% (ma ke kumu anhydrous a me ka solvent-free kumu) |
Kūlana hoʻāʻo | Kūlana ʻoihana |
Pūʻolo: ʻO ka ʻōmole, ʻeke ʻeke alumini, pahu pahu pahu, 25kg / pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;Palekana mai ka malamalama, ka ma'ū a me ka pest infestation.
ʻO Tenofovir Alafenamide Hemifumarate (TAF, GS-7340 hemifumarate), CAS 1392275-56-7, he nucleotide reverse transcriptase inhibitor (NRTIs) a me ka prodrug novel o Tenofovir (TFV).Ma ka pale ʻana i ka reverse transcriptase, pale ʻo TAF i ka maʻi HIV mai ka hoʻonui ʻana a hiki ke hōʻemi i ka nui o ka maʻi HIV i loko o ke kino.ʻO Tenofovir alafenamide kahi prodrug, ʻo ia hoʻi he lāʻau lapaʻau ʻole ia.I loko o ke kino, hoʻololi ʻia ka tenofovir alafenamide i Tenofovir diphosphate (TFV-DP).Ua ʻae ʻia ʻo Tenofovir Alafenamide Fumarate i Nowemapa 2015 no ka mālama ʻana i ka maʻi HIV-1.