trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7 Maʻemaʻe >98.0% (HPLC) Afatinib Dimaleate Intermediate

ʻO ka trans-4-Dimethylaminocrotonic Acid Hydrochloride (CAS: 848133-35-7) kahi reagent i hoʻohana ʻia i ka hoʻomākaukau ʻana i ka tyrosine kinase e kāohi ana i nā mea antitumor.Hiki ke hoʻohana ʻia ka trans-4-Dimethylaminocrotonic Acid Hydrochloride ma ke ʻano he waena o Afatinib (CAS: 439081-18-2), Afatinib Dimaleate (CAS: 850140-73-7), Neratinib (CAS: 698387-09-6).He lāʻau lapaʻau ʻo Afatinib i ʻae ʻia no ka mālama ʻana i ka maʻi maʻi maʻi maʻi ʻole liʻiliʻi liʻiliʻi (NSCLC), i hoʻomohala ʻia e Boehringer Ingelheim.Hana ia ma ke ʻano he angiokinase inhibitor.E like me Lapatinib a me Neratinib, ʻo Afatinib he tyrosine kinase inhibitor (TKI) e pale ʻole i ka epidermal growth factor receptor 2 (Her2) a me ka epidermal growth factor receptor (EGFR) kinases.ʻAʻole ikaika wale ʻo Afatinib i ka EGFRnā hoʻololi i manaʻo ʻia e nā TKI o ka hanauna mua likeerlotinib a i ʻole gefitinib, akā kūʻē pū kekahi i ka poʻe ʻike ʻole i kēia mau lāʻau lapaʻau maʻamau.Ma muli o kāna hana hou aku e kūʻē iā Her2, ke noiʻi ʻia nei no ka maʻi maʻi umauma a me nā maʻi maʻi maʻi EGFR a me Her2 ʻē aʻe.ʻO Neratinib i hoʻomohala ʻia e ka hui ʻo US Wyeth he mea hiki ʻole ke hoʻololi i ka epidermal growth factor receptor (EGFR) inhibitor.He wahi pahuhopu nui ia o nā mole liʻiliʻi tyrosine kinase inhibitors i HER 2 a me HER1 ma hope o Lapatinib, a he mea hiki ole ke hoʻololi i ka ErbB receptor tyrosine kinase inhibitor.Hiki i ka Neratinib ke kaohi i ka HER-1 a me HER-2 o ka ʻohana EGFR (ʻo IC50 he 92 nmol/L a me 59 nmol/L, kēlā me kēia).Ua hōʻike ʻia ka noiʻi haukaʻi ua hoʻohana ʻo Neratinib i ka hopena therapeutic koʻikoʻi ma luna o ka maʻi maʻi ʻaʻai liʻiliʻi liʻiliʻi, ka maʻi ʻaʻai colon, a me ka maʻi maʻi umauma.Ua hōʻike ka phaseⅡclinical trial ua hōʻike ʻo Neratinib i ka maikaʻi a me ka hoʻomanawanui ʻana i nā maʻi maʻi HER-2 maikaʻi me ka maʻi maʻi umauma kiʻekiʻe i loaʻa a ʻaʻole i mālama ʻia ʻo Trastuzumab.Ua hoʻopau ʻia ka pae Ⅲ ka hoʻāʻo ʻana i ka maʻi maʻi umauma ma Kepakemapa 2014.